Prior attenuation of KiSS1/GPR54 signaling in the anteroventral periventricular nucleus is a trigger for the delayed effect induced by neonatal exposure to 17alpha-ethynylestradiol in female rats

• Published in: Reproductive toxicology (Elmsford, N.Y.) Vol. 51; pp. 145 - 156
• Main Authors: Ichimura, Ryohei, Takahashi, Miwa, Morikawa, Tomomi, Inoue, Kaoru, Maeda, Jun, Usuda, Kento, Yokosuka, Makoto, Watanabe, Gen, Yoshida, Midori
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2015
• Subjects: 17Alpha-ethynylestradiol; Animals; AVPV; Delayed effect; EDCs; Ethinyl Estradiol - toxicity; Female; Follicle Stimulating Hormone - blood; GPR54; Hypothalamus, Anterior - drug effects; Hypothalamus, Anterior - metabolism; Kisspeptin; Kisspeptins - genetics; LH surge; Luteinizing Hormone - blood; Neonatal exposure; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Rats; Receptors, G-Protein-Coupled - genetics; Receptors, Kisspeptin-1; RNA, Messenger - metabolism; Signal Transduction - drug effects; EE; Delayed effect; 17Alpha-ethynylestradiol; 3V; P4; AVPV; IHC; GPR54; PND; LH surge; EDCs; OVX; Kisspeptin; ARC; Neonatal exposure; FSH; LH; EB; HPG; ISH

•Attenuation of LH surge and KiSS1 mRNA occurred in neonatally EE-exposed animals.•Similar serial dysfunction was also observed in 5 months old middle-aged animals.•Attenuation of KiSS1 might be caused by the decrease of ERα co-expression in AVPV.•Changing in KiSS1 might be an early toxicological in...