Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism

• Published in: Metabolism, clinical and experimental Vol. 118; p. 154731
• Main Authors: Sandhu, Bynvant, Perez-Matos, Maria C., Tran, Stephanie, Singhal, Garima, Syed, Ismail, Feldbrügge, Linda, Mitsuhashi, Shuji, Pelletier, Julie, Huang, Jinhe, Yalcin, Yusuf, Csizmadia, Eva, Tiwari-Heckler, Shilpa, Enjyoji, Keiichi, Sévigny, Jean, Maratos-Flier, Eleftheria, Robson, Simon C., Jiang, Z. Gordon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2021
• Subjects: Adipose tissue; Adipose Tissue, Brown - metabolism; Adipose Tissue, White - metabolism; Animals; Animals, Genetically Modified; Basal Metabolism; Blood Glucose - metabolism; Diet, High-Fat - adverse effects; Disease Models, Animal; Ectonucleotidase; Female; Gene Deletion; Homeostasis; Insulin - metabolism; Insulin resistance; Insulin-Secreting Cells - enzymology; Male; Mice; Mice, Inbred C57BL; NTPDase3; Obesity; Obesity - etiology; Obesity - genetics; Obesity - prevention & control; Purinergic signaling; Pyrophosphatases - genetics; Obesity; Adipose tissue; HFD; Dio2; ITT; NTPDase 3; UCP-1; WAT; NTPDase3; CLAMS; AUC; Cpt1a; FFPE; GSIS; Insulin resistance; SEM; Ectonucleotidase; OGTT; WT; RER; Purinergic signaling

Ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3), also known as CD39L3, is the dominant ectonucleotidase expressed by beta cells in the islet of Langerhans and on nerves. NTPDase3 catalyzes the conversion of extracellular ATP and ADP to AMP and modulates purinergic signaling. Previous st...