Skeletal muscle nitric oxide signaling and exercise: a focus on glucose metabolism

Nitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and this link was the subject of a Nobel prize in 1998. However, NO also plays many other regulatory roles, including thrombosis, immune function, neural activity, and gastrointestinal function. Low concentrati...

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Published inAmerican journal of physiology: endocrinology and metabolism Vol. 303; no. 3; pp. E301 - E307
Main Authors McConell, Glenn K, Rattigan, Stephen, Lee-Young, Robert S, Wadley, Glenn D, Merry, Troy L
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.08.2012
Subjects
Animals
Biosynthesis
Exercise - physiology
Glucose
Glucose - metabolism
Humans
Insulin resistance
Metabolism
Models, Biological
Muscle Contraction - physiology
Muscle, Skeletal - chemistry
Muscle, Skeletal - metabolism
Musculoskeletal system
Nitric oxide
Nitric Oxide - metabolism
Nitric Oxide Synthase - metabolism
Physiology
Signal Transduction - physiology
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Abstract Nitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and this link was the subject of a Nobel prize in 1998. However, NO also plays many other regulatory roles, including thrombosis, immune function, neural activity, and gastrointestinal function. Low concentrations of NO are thought to have important signaling effects. In contrast, high concentrations of NO can interact with reactive oxygen species, causing damage to cells and cellular components. A less-recognized site of NO production is within skeletal muscle, where small increases are thought to have beneficial effects such as regulating glucose uptake and possibly blood flow, but higher levels of production are thought to lead to deleterious effects such as an association with insulin resistance. This review will discuss the role of NO in skeletal muscle during and following exercise, including in mitochondrial biogenesis, muscle efficiency, and blood flow with a particular focus on its potential role in regulating skeletal muscle glucose uptake during exercise.
AbstractList Nitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and this link was the subject of a Nobel prize in 1998. However, NO also plays many other regulatory roles, including thrombosis, immune function, neural activity, and gastrointestinal function. Low concentrations of NO are thought to have important signaling effects. In contrast, high concentrations of NO can interact with reactive oxygen species, causing damage to cells and cellular components. A less-recognized site of NO production is within skeletal muscle, where small increases are thought to have beneficial effects such as regulating glucose uptake and possibly blood flow, but higher levels of production are thought to lead to deleterious effects such as an association with insulin resistance. This review will discuss the role of NO in skeletal muscle during and following exercise, including in mitochondrial biogenesis, muscle efficiency, and blood flow with a particular focus on its potential role in regulating skeletal muscle glucose uptake during exercise.
Nitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and this link was the subject of a Nobel prize in 1998. However, NO also plays many other regulatory roles, including thrombosis, immune function, neural activity, and gastrointestinal function. Low concentrations of NO are thought to have important signaling effects. In contrast, high concentrations of NO can interact with reactive oxygen species, causing damage to cells and cellular components. A less-recognized site of NO production is within skeletal muscle, where small increases are thought to have beneficial effects such as regulating glucose uptake and possibly blood flow, but higher levels of production are thought to lead to deleterious effects such as an association with insulin resistance. This review will discuss the role of NO in skeletal muscle during and following exercise, including in mitochondrial biogenesis, muscle efficiency, and blood flow with a particular focus on its potential role in regulating skeletal muscle glucose uptake during exercise. [PUBLICATION ABSTRACT]
Author Merry, Troy L
Lee-Young, Robert S
Rattigan, Stephen
McConell, Glenn K
Wadley, Glenn D
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  surname: McConell
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/22550064$$D View this record in MEDLINE/PubMed
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Snippet Nitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and this link was the subject of a Nobel prize in 1998. However, NO...
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SubjectTerms Animals
Biosynthesis
Exercise - physiology
Glucose
Glucose - metabolism
Humans
Insulin resistance
Metabolism
Models, Biological
Muscle Contraction - physiology
Muscle, Skeletal - chemistry
Muscle, Skeletal - metabolism
Musculoskeletal system
Nitric oxide
Nitric Oxide - metabolism
Nitric Oxide Synthase - metabolism
Physiology
Signal Transduction - physiology
Title Skeletal muscle nitric oxide signaling and exercise: a focus on glucose metabolism
URI https://www.ncbi.nlm.nih.gov/pubmed/22550064
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Volume 303
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