Patterns of p53, p73 and mortalin gene expression associated with haemocyte polyploidy in the soft-shell clam, Mya arenaria

• Published in: Journal of invertebrate pathology Vol. 98; no. 2; pp. 148 - 152
• Main Authors: Siah, A., Delaporte, M., Pariseau, J., McKenna, P., Berthe, F.C.J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.06.2008; Elsevier
• Subjects: Animal aquaculture; Animal productions; animal proteins; Animals; Biological and medical sciences; biosynthesis; Cell Transformation, Neoplastic; Cell Transformation, Neoplastic - genetics; clams; DNA-Binding Proteins; DNA-Binding Proteins - biosynthesis; DNA-Binding Proteins - genetics; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Gene Expression; Genes, p53; Genes, p53 - genetics; genetics; Haemocytes; heat shock proteins; Hematologic Neoplasms; Hematologic Neoplasms - genetics; Hematologic Neoplasms - veterinary; hemic neoplasia; hemocytes; Hemocytes - physiology; HSP70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins - biosynthesis; HSP70 Heat-Shock Proteins - genetics; Invertebrate aquaculture; Invertebrates; Mollusca; Mortalin; Mya; Mya - genetics; Mya arenaria; Nuclear Proteins; Nuclear Proteins - biosynthesis; Nuclear Proteins - genetics; p53; p73; Pathology; physiology; Polyploidy; Reverse Transcriptase Polymerase Chain Reaction; shellfish diseases; Tetraploidy; transcription factors; Tumor Protein p73; Tumor Suppressor Proteins; Tumor Suppressor Proteins - biosynthesis; Tumor Suppressor Proteins - genetics; veterinary; Canada; North America; Atlantic Ocean; Northwest Atlantic; America; Tetraploidy; Mya arenaria; Mortalin; p73; Haemocytes; p53; Edible mollusc; Disease; Gene expression; Marine environment; Hemocyte; Bivalvia; Mya arenaria;Haemocytes;p53;p73;Mortalin;Tetraploidy; Shellfish breeding; Invertebrata; Mollusca; Tumor suppressor gene

The molecular mechanisms by which haemocytes of clams are transformed in the course of haemic neoplasia remain by far unknown. The aim of this study was to quantify the expression of p53/p73 and mortalin genes, in relation with the ploidy status of clam haemocytes and to correlate the p53 expression...