Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes - POOLEY, E. C.; HOUSTON, K.; HAWTON, K.; HARRISON, P. J. (Psychological medicine, 2003)
Keywords: Adult; Adult and adolescent clinical studies; Aged; Alleles; Biological and medical sciences; Carrier Proteins - genetics; Carrier Proteins - metabolism; Case-Control Studies; Female; Genetic susceptibility; Humans; Male; Medical sciences; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Membrane Transport Proteins; Middle Aged; Monoamine Oxidase - genetics; Monoamine Oxidase - metabolism; Nerve Tissue Proteins; Parasuicide; Polymorphism, Genetic; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin - genetics; Receptors, Serotonin - metabolism; Risk Factors; Self destructive behavior; Self-Injurious Behavior - genetics; Self-Injurious Behavior - metabolism; Self-Injurious Behavior - psychology; Selfinjury; Serotonin - metabolism; Serotonin Plasma Membrane Transport Proteins; Suicide; Suicide - prevention & control; Suicide - psychology; Tryptophan Hydroxylase - genetics; Tryptophan Hydroxylase - metabolism; Human; 5-HT2A serotonin receptor; Enzyme; Genetic variant; Serotonine receptor; Genetic determinism; Amine oxidase (flavin-containing); Suicide attempt; Tryptophan 5-monooxygenase; Risk factor; 5-HT1B serotonin receptor; Genetics; Candidate gene; Oxidoreductases; Molecular biology; 5-HT2C serotonin receptor; Comparative study; Polymorphism