Membrane Morphology and Leukotoxin Secretion Are Associated with a Novel Membrane Protein of Aggregatibacter actinomycetemcomitans

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Published inJournal of Bacteriology Vol. 190; no. 17; pp. 5972 - 5980
Main Authors GALLANT, Claude V, SEDIC, Maja, CHICOINE, Erin A, RUIZ, Teresa, MINTZ, Keith P
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.09.2008
American Society for Microbiology (ASM)
Subjects
Actinobacillus actinomycetemcomitans
Aggregatibacter actinomycetemcomitans - genetics
Aggregatibacter actinomycetemcomitans - metabolism
Aggregatibacter actinomycetemcomitans - ultrastructure
Amino Acid Sequence
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Biological and medical sciences
Cell Membrane - metabolism
Cell Membrane - ultrastructure
Chromatography, Liquid
Electrophoresis, Polyacrylamide Gel
Exotoxins - secretion
Fundamental and applied biological sciences. Psychology
Haemophilus influenzae
Hydrophobic and Hydrophilic Interactions
Immunoblotting
Membrane Proteins - chemistry
Membrane Proteins - genetics
Membrane Proteins - metabolism
Microbiology
Microscopy, Electron, Transmission
Miscellaneous
Molecular Biology of Pathogens
Molecular Sequence Data
Mutagenesis, Insertional
Operon - genetics
Pasteurella multocida
Promoter Regions, Genetic - genetics
Reverse Transcriptase Polymerase Chain Reaction
Sequence Homology, Amino Acid
Spectrometry, Mass, Electrospray Ionization
Pasteurellaceae
Leukotoxin
Toxin
Aggregatibacter actinomycetemcomitans
Membrane protein
Microbiology
Secretion
Morphology
Bacteria
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Abstract Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0021-9193 Online ISSN: 1098-5530 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JB .asm.org, visit: JB       
AbstractList Gram-negative bacteria display either a flat or an irregular outer membrane. The periodontal pathogen Aggregatibacter (Actinobacillus) actinomycetemcomitans has an irregular outer membrane. We have identified a gene that is associated with the biogenesis of this morphology. The gene is part of a three-gene operon and codes for a 141-kDa protein designated morphogenesis protein C (MorC), which is conserved in several gram-negative bacteria including Haemophilus influenzae and Pasteurella multocida. Insertional inactivation of this gene resulted in the conversion of an irregularly shaped membrane to a flat membrane. Associated with this morphological change were the autoaggregation of the bacteria during planktonic growth and a concomitant increase in the surface hydrophobicity of the bacterium. The absence of MorC also resulted in the loss of the secretion of leukotoxin but not the ltxA transcription. Our findings suggest that MorC is critical for membrane morphology and leukotoxin secretion in A. actinomycetemcomitans.
ABSTRACT Gram-negative bacteria display either a flat or an irregular outer membrane. The periodontal pathogen Aggregatibacter ( Actinobacillus ) actinomycetemcomitans has an irregular outer membrane. We have identified a gene that is associated with the biogenesis of this morphology. The gene is part of a three-gene operon and codes for a 141-kDa protein designated morphogenesis protein C (MorC), which is conserved in several gram-negative bacteria including Haemophilus influenzae and Pasteurella multocida . Insertional inactivation of this gene resulted in the conversion of an irregularly shaped membrane to a flat membrane. Associated with this morphological change were the autoaggregation of the bacteria during planktonic growth and a concomitant increase in the surface hydrophobicity of the bacterium. The absence of MorC also resulted in the loss of the secretion of leukotoxin but not the ltxA transcription. Our findings suggest that MorC is critical for membrane morphology and leukotoxin secretion in A. actinomycetemcomitans .
Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0021-9193 Online ISSN: 1098-5530 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JB .asm.org, visit: JB       
Gram-negative bacteria display either a flat or an irregular outer membrane. The periodontal pathogen Aggregatibacter ( Actinobacillus ) actinomycetemcomitans has an irregular outer membrane. We have identified a gene that is associated with the biogenesis of this morphology. The gene is part of a three-gene operon and codes for a 141-kDa protein designated morphogenesis protein C (MorC), which is conserved in several gram-negative bacteria including Haemophilus influenzae and Pasteurella multocida . Insertional inactivation of this gene resulted in the conversion of an irregularly shaped membrane to a flat membrane. Associated with this morphological change were the autoaggregation of the bacteria during planktonic growth and a concomitant increase in the surface hydrophobicity of the bacterium. The absence of MorC also resulted in the loss of the secretion of leukotoxin but not the ltxA transcription. Our findings suggest that MorC is critical for membrane morphology and leukotoxin secretion in A. actinomycetemcomitans .
Author Keith P. Mintz
Claude V. Gallant
Teresa Ruiz
Maja Sedic
Erin A. Chicoine
AuthorAffiliation Department of Microbiology and Molecular Genetics, 1 Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 2
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Issue 17
Keywords Pasteurellaceae
Leukotoxin
Toxin
Aggregatibacter actinomycetemcomitans
Membrane protein
Microbiology
Secretion
Morphology
Bacteria
Language English
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Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, Rm. 118, Stafford Hall, University of Vermont, Burlington, VT 05405. Phone: (802) 656-0712. Fax: (802) 656-8749. E-mail: Keith.Mintz@uvm.edu
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Gram-negative bacteria display either a flat or an irregular outer membrane. The periodontal pathogen Aggregatibacter (Actinobacillus) actinomycetemcomitans...
ABSTRACT Gram-negative bacteria display either a flat or an irregular outer membrane. The periodontal pathogen Aggregatibacter ( Actinobacillus )...
Gram-negative bacteria display either a flat or an irregular outer membrane. The periodontal pathogen Aggregatibacter ( Actinobacillus ) actinomycetemcomitans...
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SubjectTerms Actinobacillus actinomycetemcomitans
Aggregatibacter actinomycetemcomitans - genetics
Aggregatibacter actinomycetemcomitans - metabolism
Aggregatibacter actinomycetemcomitans - ultrastructure
Amino Acid Sequence
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Biological and medical sciences
Cell Membrane - metabolism
Cell Membrane - ultrastructure
Chromatography, Liquid
Electrophoresis, Polyacrylamide Gel
Exotoxins - secretion
Fundamental and applied biological sciences. Psychology
Haemophilus influenzae
Hydrophobic and Hydrophilic Interactions
Immunoblotting
Membrane Proteins - chemistry
Membrane Proteins - genetics
Membrane Proteins - metabolism
Microbiology
Microscopy, Electron, Transmission
Miscellaneous
Molecular Biology of Pathogens
Molecular Sequence Data
Mutagenesis, Insertional
Operon - genetics
Pasteurella multocida
Promoter Regions, Genetic - genetics
Reverse Transcriptase Polymerase Chain Reaction
Sequence Homology, Amino Acid
Spectrometry, Mass, Electrospray Ionization
Title Membrane Morphology and Leukotoxin Secretion Are Associated with a Novel Membrane Protein of Aggregatibacter actinomycetemcomitans
URI http://jb.asm.org/content/190/17/5972.abstract
https://www.ncbi.nlm.nih.gov/pubmed/18621903
https://search.proquest.com/docview/21491022
https://pubmed.ncbi.nlm.nih.gov/PMC2519528
Volume 190
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