Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS

• Published in: Oxidative medicine and cellular longevity Vol. 2014; no. 2014; pp. 1 - 12
• Main Authors: Tsikas, Dimitrios, Stichtenoth, Dirk O., Staerk, Ulrich, Probst, Irmelin, Suchy, Maria-Theresia, Böhmer, Anke, Trettin, Arne, Frölich, Jürgen C.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2014; John Wiley & Sons, Inc
• Subjects: Acetaminophen; Acetaminophen - pharmacology; Adult; Animals; Cytochrome P-450 Enzyme System - metabolism; Drug metabolism; Enzymes; Epoprostenol - biosynthesis; Genetic aspects; Hepatocytes - drug effects; Hepatocytes - enzymology; Humans; Male; Middle Aged; Nitric Oxide - metabolism; Nitric Oxide Synthase - genetics; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase - pharmacology; Nitric Oxide Synthase Type II - genetics; Nitric Oxide Synthase Type II - metabolism; Nitric Oxide Synthase Type II - pharmacology; Nitric Oxide Synthase Type III - genetics; Nitric Oxide Synthase Type III - metabolism; Nitric Oxide Synthase Type III - pharmacology; Oxidative stress; Oxidative Stress - drug effects; Patient outcomes; Prostaglandin-Endoperoxide Synthases - metabolism; Rats; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Recombinant Proteins - pharmacology; Regulation; Thromboxanes - biosynthesis

Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). We investigated the effects of paracetamol on p...