Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS - Tsikas, Dimitrios; Stichtenoth, Dirk O.; Staerk, Ulrich; Probst, Irmelin; Suchy, Maria-Theresia; Böhmer, Anke; Trettin, Arne; Frölich, Jürgen C. (Oxidative medicine and cellular longevity, 2014)
Keywords: Acetaminophen; Acetaminophen - pharmacology; Adult; Animals; Cytochrome P-450 Enzyme System - metabolism; Drug metabolism; Enzymes; Epoprostenol - biosynthesis; Genetic aspects; Hepatocytes - drug effects; Hepatocytes - enzymology; Humans; Male; Middle Aged; Nitric Oxide - metabolism; Nitric Oxide Synthase - genetics; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase - pharmacology; Nitric Oxide Synthase Type II - genetics; Nitric Oxide Synthase Type II - metabolism; Nitric Oxide Synthase Type II - pharmacology; Nitric Oxide Synthase Type III - genetics; Nitric Oxide Synthase Type III - metabolism; Nitric Oxide Synthase Type III - pharmacology; Oxidative stress; Oxidative Stress - drug effects; Patient outcomes; Prostaglandin-Endoperoxide Synthases - metabolism; Rats; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Recombinant Proteins - pharmacology; Regulation; Thromboxanes - biosynthesis