Weak brain function and anxiety-related loop in harm-avoidance personality: A resting-state functional magnetic resonance imaging study
Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality. A total of 97 young subjects w...
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Published in | Brain research bulletin Vol. 220; p. 111174 |
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Main Authors | , , , , , , , |
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Language | English |
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01.01.2025
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Abstract | Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality.
A total of 97 young subjects were included. All subjects completed personality, emotion, and cognition scales, and resting-state functional magnetic resonance imaging scan. All subjects were divided into subtypes of harm avoidance (HA) and reward dependence (RD) by clustering analysis. Graph theory analysis and network-based analysis were used to explore the brain functional configurations of personalities.
HA subjects showed lower network metrics (P = 0.018) and node metrics (P < 0.009). A negative component network was observed in HA subjects (P < 0.001). Functional topology metrics were negatively correlated with the HA score. The amygdala-IPG functional connectivity mediated the positive correlation between personality HA and state anxiety.
Personality HA is associated with decreased functional configuration, which could influence emotion by downregulating amygdala-IPG coupling. These findings provide insight into how the brain shapes personality and related emotions.
•Harm-avoid adolescence had higher emotion dysfunction.•Harm-avoid personality was closely associated with a decreased functional configuration.•Functional topology was negatively correlated with harm-avoid score in adolescence.•Harm-avoid personality influenced emotion by downregulating amygdala-IPG coupling. |
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AbstractList | Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality.
A total of 97 young subjects were included. All subjects completed personality, emotion, and cognition scales, and resting-state functional magnetic resonance imaging scan. All subjects were divided into subtypes of harm avoidance (HA) and reward dependence (RD) by clustering analysis. Graph theory analysis and network-based analysis were used to explore the brain functional configurations of personalities.
HA subjects showed lower network metrics (P = 0.018) and node metrics (P < 0.009). A negative component network was observed in HA subjects (P < 0.001). Functional topology metrics were negatively correlated with the HA score. The amygdala-IPG functional connectivity mediated the positive correlation between personality HA and state anxiety.
Personality HA is associated with decreased functional configuration, which could influence emotion by downregulating amygdala-IPG coupling. These findings provide insight into how the brain shapes personality and related emotions.
•Harm-avoid adolescence had higher emotion dysfunction.•Harm-avoid personality was closely associated with a decreased functional configuration.•Functional topology was negatively correlated with harm-avoid score in adolescence.•Harm-avoid personality influenced emotion by downregulating amygdala-IPG coupling. Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality. A total of 97 young subjects were included. All subjects completed personality, emotion, and cognition scales, and resting-state functional magnetic resonance imaging scan. All subjects were divided into subtypes of harm avoidance (HA) and reward dependence (RD) by clustering analysis. Graph theory analysis and network-based analysis were used to explore the brain functional configurations of personalities. HA subjects showed lower network metrics (P = 0.018) and node metrics (P < 0.009). A negative component network was observed in HA subjects (P < 0.001). Functional topology metrics were negatively correlated with the HA score. The amygdala-IPG functional connectivity mediated the positive correlation between personality HA and state anxiety. Personality HA is associated with decreased functional configuration, which could influence emotion by downregulating amygdala-IPG coupling. These findings provide insight into how the brain shapes personality and related emotions. Background: Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality. Methods: A total of 97 young subjects were included. All subjects completed personality, emotion, and cognition scales, and resting-state functional magnetic resonance imaging scan. All subjects were divided into subtypes of harm avoidance (HA) and reward dependence (RD) by clustering analysis. Graph theory analysis and network-based analysis were used to explore the brain functional configurations of personalities. Results: HA subjects showed lower network metrics (P = 0.018) and node metrics (P < 0.009). A negative component network was observed in HA subjects (P < 0.001). Functional topology metrics were negatively correlated with the HA score. The amygdala-IPG functional connectivity mediated the positive correlation between personality HA and state anxiety. Conclusion: Personality HA is associated with decreased functional configuration, which could influence emotion by downregulating amygdala-IPG coupling. These findings provide insight into how the brain shapes personality and related emotions. |
ArticleNumber | 111174 |
Author | Xu, Xiaojun Wen, Jiaqi Guan, Xiaojun Duanmu, Xiaojie Xu, Jingjing Zhang, Minming Guo, Tao Tan, Sijia |
Author_xml | – sequence: 1 givenname: Jiaqi surname: Wen fullname: Wen, Jiaqi organization: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China – sequence: 2 givenname: Tao surname: Guo fullname: Guo, Tao organization: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China – sequence: 3 givenname: Jingjing surname: Xu fullname: Xu, Jingjing organization: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China – sequence: 4 givenname: Xiaojie surname: Duanmu fullname: Duanmu, Xiaojie organization: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China – sequence: 5 givenname: Sijia surname: Tan fullname: Tan, Sijia organization: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China – sequence: 6 givenname: Minming surname: Zhang fullname: Zhang, Minming organization: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China – sequence: 7 givenname: Xiaojun surname: Xu fullname: Xu, Xiaojun email: xxjmailbox@zju.edu.cn organization: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China – sequence: 8 givenname: Xiaojun surname: Guan fullname: Guan, Xiaojun email: xiaojunguan1102@zju.edu.cn organization: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39701427$$D View this record in MEDLINE/PubMed |
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Keywords | Functional magnetic resonance imaging Clustering analysis Mediating analysis Personality Anxiety |
Language | English |
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SubjectTerms | Adolescent Adult Amygdala - physiology Anxiety Anxiety - diagnostic imaging Anxiety - physiopathology Brain - diagnostic imaging Brain - physiology Brain - physiopathology Brain Mapping - methods Clustering analysis Emotions - physiology Female Functional magnetic resonance imaging Harm Reduction - physiology Humans Magnetic Resonance Imaging - methods Male Mediating analysis Personality Personality - physiology Rest Reward Young Adult |
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Title | Weak brain function and anxiety-related loop in harm-avoidance personality: A resting-state functional magnetic resonance imaging study |
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