Weak brain function and anxiety-related loop in harm-avoidance personality: A resting-state functional magnetic resonance imaging study

Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality. A total of 97 young subjects w...

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Published inBrain research bulletin Vol. 220; p. 111174
Main Authors Wen, Jiaqi, Guo, Tao, Xu, Jingjing, Duanmu, Xiaojie, Tan, Sijia, Zhang, Minming, Xu, Xiaojun, Guan, Xiaojun
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2025
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Abstract Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality. A total of 97 young subjects were included. All subjects completed personality, emotion, and cognition scales, and resting-state functional magnetic resonance imaging scan. All subjects were divided into subtypes of harm avoidance (HA) and reward dependence (RD) by clustering analysis. Graph theory analysis and network-based analysis were used to explore the brain functional configurations of personalities. HA subjects showed lower network metrics (P = 0.018) and node metrics (P < 0.009). A negative component network was observed in HA subjects (P < 0.001). Functional topology metrics were negatively correlated with the HA score. The amygdala-IPG functional connectivity mediated the positive correlation between personality HA and state anxiety. Personality HA is associated with decreased functional configuration, which could influence emotion by downregulating amygdala-IPG coupling. These findings provide insight into how the brain shapes personality and related emotions. •Harm-avoid adolescence had higher emotion dysfunction.•Harm-avoid personality was closely associated with a decreased functional configuration.•Functional topology was negatively correlated with harm-avoid score in adolescence.•Harm-avoid personality influenced emotion by downregulating amygdala-IPG coupling.
AbstractList Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality. A total of 97 young subjects were included. All subjects completed personality, emotion, and cognition scales, and resting-state functional magnetic resonance imaging scan. All subjects were divided into subtypes of harm avoidance (HA) and reward dependence (RD) by clustering analysis. Graph theory analysis and network-based analysis were used to explore the brain functional configurations of personalities. HA subjects showed lower network metrics (P = 0.018) and node metrics (P < 0.009). A negative component network was observed in HA subjects (P < 0.001). Functional topology metrics were negatively correlated with the HA score. The amygdala-IPG functional connectivity mediated the positive correlation between personality HA and state anxiety. Personality HA is associated with decreased functional configuration, which could influence emotion by downregulating amygdala-IPG coupling. These findings provide insight into how the brain shapes personality and related emotions. •Harm-avoid adolescence had higher emotion dysfunction.•Harm-avoid personality was closely associated with a decreased functional configuration.•Functional topology was negatively correlated with harm-avoid score in adolescence.•Harm-avoid personality influenced emotion by downregulating amygdala-IPG coupling.
Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality. A total of 97 young subjects were included. All subjects completed personality, emotion, and cognition scales, and resting-state functional magnetic resonance imaging scan. All subjects were divided into subtypes of harm avoidance (HA) and reward dependence (RD) by clustering analysis. Graph theory analysis and network-based analysis were used to explore the brain functional configurations of personalities. HA subjects showed lower network metrics (P = 0.018) and node metrics (P < 0.009). A negative component network was observed in HA subjects (P < 0.001). Functional topology metrics were negatively correlated with the HA score. The amygdala-IPG functional connectivity mediated the positive correlation between personality HA and state anxiety. Personality HA is associated with decreased functional configuration, which could influence emotion by downregulating amygdala-IPG coupling. These findings provide insight into how the brain shapes personality and related emotions.
Background: Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality. Methods: A total of 97 young subjects were included. All subjects completed personality, emotion, and cognition scales, and resting-state functional magnetic resonance imaging scan. All subjects were divided into subtypes of harm avoidance (HA) and reward dependence (RD) by clustering analysis. Graph theory analysis and network-based analysis were used to explore the brain functional configurations of personalities. Results: HA subjects showed lower network metrics (P = 0.018) and node metrics (P < 0.009). A negative component network was observed in HA subjects (P < 0.001). Functional topology metrics were negatively correlated with the HA score. The amygdala-IPG functional connectivity mediated the positive correlation between personality HA and state anxiety. Conclusion: Personality HA is associated with decreased functional configuration, which could influence emotion by downregulating amygdala-IPG coupling. These findings provide insight into how the brain shapes personality and related emotions.
ArticleNumber 111174
Author Xu, Xiaojun
Wen, Jiaqi
Guan, Xiaojun
Duanmu, Xiaojie
Xu, Jingjing
Zhang, Minming
Guo, Tao
Tan, Sijia
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Keywords Functional magnetic resonance imaging
Clustering analysis
Mediating analysis
Personality
Anxiety
Language English
License This is an open access article under the CC BY-NC-ND license.
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
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Snippet Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles...
Background: Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term...
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SubjectTerms Adolescent
Adult
Amygdala - physiology
Anxiety
Anxiety - diagnostic imaging
Anxiety - physiopathology
Brain - diagnostic imaging
Brain - physiology
Brain - physiopathology
Brain Mapping - methods
Clustering analysis
Emotions - physiology
Female
Functional magnetic resonance imaging
Harm Reduction - physiology
Humans
Magnetic Resonance Imaging - methods
Male
Mediating analysis
Personality
Personality - physiology
Rest
Reward
Young Adult
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Title Weak brain function and anxiety-related loop in harm-avoidance personality: A resting-state functional magnetic resonance imaging study
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