Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats

•Lower body weight.•Lower organ coefficient of ovary.•Higher GnRH level in the hypothalamus.•Higher mRNA and protein levels of GnRHR in the pituitary.•Lower serum sex hormone levels. Thus, DEHP affects the function of hypothalamus-pituitary-ovarian axis in adult female rat. Di-(2-ethylhexyl) phthala...

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Published inReproductive toxicology (Elmsford, N.Y.) Vol. 46; pp. 141 - 147
Main Authors Liu, Te, Li, Na, Zhu, Jian, Yu, Guangyan, Guo, Kun, Zhou, Liting, Zheng, Dongchun, Qu, Xiaofeng, Huang, Jian, Chen, Xin, Wang, Shuyue, Ye, Lin
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2014
Subjects
Animals
Body Weight - drug effects
Di-(2-ethylhexyl) phthalate
Diethylhexyl Phthalate - toxicity
Endocrine disruptors
Female
Gene Expression Regulation - drug effects
Gonadal Steroid Hormones - metabolism
Gonadotropin-Releasing Hormone - metabolism
HPOA
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - metabolism
Ovary - drug effects
Ovary - metabolism
Plasticizers - toxicity
Rats
Rats, Wistar
Reproductive toxicity
Sex hormone
Uterus - drug effects
Endocrine disruptors
HPOA
Di-(2-ethylhexyl) phthalate
Reproductive toxicity
Sex hormone
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Abstract •Lower body weight.•Lower organ coefficient of ovary.•Higher GnRH level in the hypothalamus.•Higher mRNA and protein levels of GnRHR in the pituitary.•Lower serum sex hormone levels. Thus, DEHP affects the function of hypothalamus-pituitary-ovarian axis in adult female rat. Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely present in the environment and some products with phthalate plasticizer. It has become a serious problem in recent years. The effect of DEHP on female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on hypothalamus-pituitary-ovarian axis in adult female rats. Compared with control rats, the DEHP-treated rats showed: (1) lower body weight; (2) lower organ coefficient of ovary; (3) higher GnRH level in the hypothalamus; (4) higher mRNA and protein levels of GnRHR in the pituitary; and (5) lower serum sex hormone levels. Our data reveal that DEHP exposure may lead to the disruption of estrogen biosynthesis pathways in female rats and imbalance of hypothalamus-pituitary-ovarian axis. DEHP may impose negative influence on the development and function of the reproductive system in female rats.
AbstractList •Lower body weight.•Lower organ coefficient of ovary.•Higher GnRH level in the hypothalamus.•Higher mRNA and protein levels of GnRHR in the pituitary.•Lower serum sex hormone levels. Thus, DEHP affects the function of hypothalamus-pituitary-ovarian axis in adult female rat. Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely present in the environment and some products with phthalate plasticizer. It has become a serious problem in recent years. The effect of DEHP on female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on hypothalamus-pituitary-ovarian axis in adult female rats. Compared with control rats, the DEHP-treated rats showed: (1) lower body weight; (2) lower organ coefficient of ovary; (3) higher GnRH level in the hypothalamus; (4) higher mRNA and protein levels of GnRHR in the pituitary; and (5) lower serum sex hormone levels. Our data reveal that DEHP exposure may lead to the disruption of estrogen biosynthesis pathways in female rats and imbalance of hypothalamus-pituitary-ovarian axis. DEHP may impose negative influence on the development and function of the reproductive system in female rats.
Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely present in the environment and some products with phthalate plasticizer. It has become a serious problem in recent years. The effect of DEHP on female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on hypothalamus-pituitary-ovarian axis in adult female rats. Compared with control rats, the DEHP-treated rats showed: (1) lower body weight; (2) lower organ coefficient of ovary; (3) higher GnRH level in the hypothalamus; (4) higher mRNA and protein levels of GnRHR in the pituitary; and (5) lower serum sex hormone levels. Our data reveal that DEHP exposure may lead to the disruption of estrogen biosynthesis pathways in female rats and imbalance of hypothalamus-pituitary-ovarian axis. DEHP may impose negative influence on the development and function of the reproductive system in female rats.
Author Zheng, Dongchun
Huang, Jian
Chen, Xin
Liu, Te
Zhou, Liting
Li, Na
Zhu, Jian
Yu, Guangyan
Wang, Shuyue
Guo, Kun
Ye, Lin
Qu, Xiaofeng
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  surname: Chen
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– sequence: 11
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  surname: Wang
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  organization: Department of Emergency, China Japan Union Hospital, Jilin University, Changchun, China
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  givenname: Lin
  surname: Ye
  fullname: Ye, Lin
  email: jlyelin@163.com
  organization: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China
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Keywords Endocrine disruptors
HPOA
Di-(2-ethylhexyl) phthalate
Reproductive toxicity
Sex hormone
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Snippet •Lower body weight.•Lower organ coefficient of ovary.•Higher GnRH level in the hypothalamus.•Higher mRNA and protein levels of GnRHR in the pituitary.•Lower...
Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely present in the environment and some products with phthalate plasticizer. It...
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SubjectTerms Animals
Body Weight - drug effects
Di-(2-ethylhexyl) phthalate
Diethylhexyl Phthalate - toxicity
Endocrine disruptors
Female
Gene Expression Regulation - drug effects
Gonadal Steroid Hormones - metabolism
Gonadotropin-Releasing Hormone - metabolism
HPOA
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - metabolism
Ovary - drug effects
Ovary - metabolism
Plasticizers - toxicity
Rats
Rats, Wistar
Reproductive toxicity
Sex hormone
Uterus - drug effects
Title Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats
URI https://dx.doi.org/10.1016/j.reprotox.2014.03.006
https://www.ncbi.nlm.nih.gov/pubmed/24675100
https://search.proquest.com/docview/1627949241
Volume 46
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