Ageing of the B-cell repertoire

• Published in: Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 370; no. 1676; p. 20140237
• Main Authors: Martin, Victoria, Wu, Yu-Chang (Bryan), Kipling, David, Dunn-Walters, Deborah
• Format: Journal Article
• Language: English
• Published: England The Royal Society 05.09.2015
• Subjects: Adult; Aged; Aged, 80 and over; Ageing; Aging - immunology; B-Cell Memory; B-Lymphocyte Subsets - immunology; Clonal Selection, Antigen-Mediated; Humans; Immunoglobulin Class Switching; Immunoglobulin Repertoire; Immunoglobulins - genetics; Immunologic Memory; Middle Aged; Subclass Of Antibody; V(D)J Recombination; Young Adult; B-cell memory; subclass of antibody; ageing; immunoglobulin repertoire

Older people are more susceptible to infection, less responsive to vaccination and have a more inflammatory immune environment. Using spectratype analysis, we have previously shown that the B-cell repertoire of older people shows evidence of inappropriate clonal expansions in the absence of challeng...