Detection of Clostridium perfringens toxin genes in the gut microbiota of autistic children

• Published in: Anaerobe Vol. 45; pp. 133 - 137
• Main Authors: Finegold, Sydney M., Summanen, Paula H., Downes, Julia, Corbett, Karen, Komoriya, Tomoe
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2017
• Subjects: Autism; Autistic Disorder - microbiology; Bacterial Toxins - genetics; Bacteriological Techniques; Beta2 toxin; Child; Child, Preschool; children; Clostridium perfringens; Clostridium perfringens - genetics; Clostridium perfringens - isolation & purification; digestive system diseases; enterotoxins; feces; Feces - microbiology; Female; gastrointestinal system; Gastrointestinal Tract - microbiology; genes; Humans; intestinal microorganisms; Male; Microbiome; Polymerase Chain Reaction; Toxin gene; UV; GI; AAD; Beta2 toxin; ATCC; Clostridium perfringens; Autism; SD; ASD; CFU; DNA; CPE; Toxin gene; PCR; Microbiome

We studied stool specimens from 33 autistic children aged 2–9 years with gastrointestinal (GI) abnormalities and 13 control children without autism and without GI symptoms. We performed quantitative comparison of all Clostridium species and Clostridium perfringens strains from the fecal microbiota b...