Piperacillin–sulbactam versus piperacillin–tazobactam: a multicentre, randomised, single-blind, controlled clinical trial

• Published in: International journal of antimicrobial agents Vol. 26; no. 1; pp. 22 - 27
• Main Authors: Zhiyong, Zong, Xiaoju, Lü, Yanbin, Liu, Yao, Yang, Rujia, Yu, Xueqin, Fu, Wenxiang, Huang, Sufang, Cai, Zebo, Yu, Xingping, Zeng, Minggang, Duan, Peiyuan, Xia, Weiming, Zhu, Xianghui, Ji, Hongwen, Zhao, Yongchuan, Chen, Fei, Yin, Zongzan, Ni
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 01.07.2005; Amsterdam Elsevier; New York, NY
• Subjects: Adult; Anti-Bacterial Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial infection; Biological and medical sciences; Drug Combinations; Female; Humans; Male; Medical sciences; Middle Aged; Penicillanic Acid - analogs & derivatives; Penicillanic Acid - therapeutic use; Pharmacology. Drug treatments; Piperacillin; Piperacillin - therapeutic use; RCT; Respiratory Tract Infections - drug therapy; Single-Blind Method; Sulbactam; Sulbactam - therapeutic use; Tazobactam; Urinary Tract Infections - drug therapy; Bacterial infection; RCT; Tazobactam; Sulbactam; Piperacillin; Human; Enzyme; β-Lactams; Enzyme inhibitor; β-Lactamase; Penicillin derivatives; Antibiotic; Randomization; Hydrolases; Clinical trial; Antibacterial agent; Comparative study

The objective of this study was to compare the efficacy and safety of piperacillin–sulbactam (PIP–SBT) and piperacillin–tazobactam (PIP–TAZ) in the treatment of bacterial respiratory and urinary tract infections. A randomised, single-blind, controlled clinical trial was performed. Differences in cli...