Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2

Coronavirus disease 2019 (COVID-19) is an illness caused by the new coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). It has affected public health and the economy globally. Currently approved vaccines and other drug candidates could be associated with several drawbacks...

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Bibliographic Details
Published inMicrobial pathogenesis Vol. 168; p. 105512
Main Authors Uma Reddy, B., Routhu, Nanda Kishore, Kumar, Anuj
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.07.2022
Subjects
Antiviral therapeutics
COVID-19
Plants
SARS-CoV-2
Small molecule inhibitors
Viral replication cycle
COVID-19
SARS-CoV-2
Plants
Small molecule inhibitors
Viral replication cycle
Antiviral therapeutics
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Summary:Coronavirus disease 2019 (COVID-19) is an illness caused by the new coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). It has affected public health and the economy globally. Currently approved vaccines and other drug candidates could be associated with several drawbacks which urges developing alternative therapeutic approaches. To provide a comprehensive review of anti-SARS-CoV-2 activities of plants and their bioactive compounds. Information was gathered from diverse bibliographic platforms such as PubMed, Google Scholar, and ClinicalTrials.gov registry. The present review highlights the potential roles of crude extracts of plants as well as plant-derived small molecules in inhibiting SARS-CoV-2 infection by targeting viral or host factors essential for viral entry, polyprotein processing, replication, assembly and release. Their anti-inflammatory and antioxidant properties as well as plant-based therapies that are under development in the clinical trial phases-1 to 3 are also covered. This knowledge could further help understanding SARS-CoV-2 infection and anti-viral mechanisms of plant-based therapeutics. [Display omitted] •Phytocompounds affect the crucial steps of SARS-CoV-2 infection cycle.•Phytocompounds display strong affinities to the key viral enzymes.•These molecules also exhibit greater stability and a higher safety profile.•They can be used as an alternative therapeutic approach to treat COVID-19.
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Equal corresponding authors
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2022.105512