Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

Autophagy allows cells to self-digest portions of their own cytoplasm for a multitude of physiological purposes, including innate and adaptive immunity functions. In one of its innate immunity manifestations, autophagy, is known to contribute to the killing of intracellular microbes, including Mycob...

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Published in	Immunity (Cambridge, Mass.) Vol. 32; no. 3; pp. 329 - 341
Main Authors	Ponpuak, Marisa, Davis, Alexander S., Roberts, Esteban A., Delgado, Monica A., Dinkins, Christina, Zhao, Zijiang, Virgin, Herbert W., Kyei, George B., Johansen, Terje, Vergne, Isabelle, Deretic, Vojo
Format	Journal Article
Language	English
Published	United States Elsevier Inc 26.03.2010 Elsevier Limited
Subjects	Acidification Adaptor Proteins, Signal Transducing - immunology Animals Antimicrobial agents Autophagy Biological Transport Cells, Cultured Cytosol - immunology Cytosol - metabolism Heat-Shock Proteins - immunology Mice Mice, Inbred C57BL MOLIMMUNO Mycobacterium Mycobacterium tuberculosis - immunology Phagosomes - immunology Phagosomes - metabolism Protein Binding Proteins Sequestosome-1 Protein Ubiquitin - metabolism MOLIMMUNO
Online Access	Get full text
ISSN	1074-7613 1097-4180 1097-4180
DOI	10.1016/j.immuni.2010.02.009

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Abstract	Autophagy allows cells to self-digest portions of their own cytoplasm for a multitude of physiological purposes, including innate and adaptive immunity functions. In one of its innate immunity manifestations, autophagy, is known to contribute to the killing of intracellular microbes, including Mycobacterium tuberculosis, although the molecular mechanisms have been unclear. Here, we delineated sequential steps of the autophagic pathway necessary to control intracellular M. tuberculosis and found that in addition to autophagy initiation and maturation, an accessory autophagy-targeting molecule p62 (A170 or SQSTM1) was required for mycobactericidal activity. The p62 adaptor protein delivered specific ribosomal and bulk ubiquitinated cytosolic proteins to autolysosomes where they were proteolytically converted into products capable of killing M. tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles. [Display omitted] ► Autophagy converts specific cytoplasmic proteins into antimicrobial peptides ► Autophagic adaptor p62 delivers Fau and ubiquitinated complexes to autolysosomes ► Ribosomal proteins and ubiquitin are digested by lysosomal hydrolases in autolysosomes ► Conversion of cytoplasmic proteins into bactericidal peptides kills M. tuberculosis
AbstractList	Autophagy allows cells to self-digest portions of their own cytoplasm for a multitude of physiological purposes, including innate and adaptive immunity functions. In one of its innate immunity manifestations, autophagy, is known to contribute to the killing of intracellular microbes, including Mycobecterium tuberculosis, although the molecular mechanisms have been unclear. Here, we delineated sequential steps of the autophagic pathway necessary to control intracellular M. tuberculosis and found that in addition to autophagy initiation and maturation, an accessory autophagy-targeting molecule p62 (A170 or SQSTM1) was required for mycobactericidal activity. The p62 adaptor protein delivered specific ribosomal and bulk ubiquitinated cytosolic proteins to autolysosomes where they were proteolytically converted into products capable of killing M. tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles. Autophagy allows cells to self-digest portions of their own cytoplasm for a multitude of physiological purposes, including innate and adaptive immunity functions. In one of its innate immunity manifestations, autophagy, is known to contribute to the killing of intracellular microbes, including Mycobacterium tuberculosis, although the molecular mechanisms have been unclear. Here, we delineated sequential steps of the autophagic pathway necessary to control intracellular M. tuberculosis and found that in addition to autophagy initiation and maturation, an accessory autophagy-targeting molecule p62 (A170 or SQSTM1) was required for mycobactericidal activity. The p62 adaptor protein delivered specific ribosomal and bulk ubiquitinated cytosolic proteins to autolysosomes where they were proteolytically converted into products capable of killing M. tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles. Autophagy allows cells to self-digest portions of their own cytoplasm for a multitude of physiological purposes, including innate and adaptive immunity functions. In one of its innate immunity manifestations, autophagy, is known to contribute to the killing of intracellular microbes, including Mycobacterium tuberculosis, although the molecular mechanisms have been unclear. Here, we delineated sequential steps of the autophagic pathway necessary to control intracellular M. tuberculosis and found that in addition to autophagy initiation and maturation, an accessory autophagy-targeting molecule p62 (A170 or SQSTM1) was required for mycobactericidal activity. The p62 adaptor protein delivered specific ribosomal and bulk ubiquitinated cytosolic proteins to autolysosomes where they were proteolytically converted into products capable of killing M. tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles. [Display omitted] ► Autophagy converts specific cytoplasmic proteins into antimicrobial peptides ► Autophagic adaptor p62 delivers Fau and ubiquitinated complexes to autolysosomes ► Ribosomal proteins and ubiquitin are digested by lysosomal hydrolases in autolysosomes ► Conversion of cytoplasmic proteins into bactericidal peptides kills M. tuberculosis Autophagy allows cells to self-digest portions of their own cytoplasm for a multitude of physiological purposes, including innate and adaptive immunity functions. In one of its innate immunity manifestations, autophagy, is known to contribute to the killing of intracellular microbes, including Mycobacterium tuberculosis, although the molecular mechanisms have been unclear. Here, we delineated sequential steps of the autophagic pathway necessary to control intracellular M. tuberculosis and found that in addition to autophagy initiation and maturation, an accessory autophagy-targeting molecule p62 (A170 or SQSTM1) was required for mycobactericidal activity. The p62 adaptor protein delivered specific ribosomal and bulk ubiquitinated cytosolic proteins to autolysosomes where they were proteolytically converted into products capable of killing M. tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles.Autophagy allows cells to self-digest portions of their own cytoplasm for a multitude of physiological purposes, including innate and adaptive immunity functions. In one of its innate immunity manifestations, autophagy, is known to contribute to the killing of intracellular microbes, including Mycobacterium tuberculosis, although the molecular mechanisms have been unclear. Here, we delineated sequential steps of the autophagic pathway necessary to control intracellular M. tuberculosis and found that in addition to autophagy initiation and maturation, an accessory autophagy-targeting molecule p62 (A170 or SQSTM1) was required for mycobactericidal activity. The p62 adaptor protein delivered specific ribosomal and bulk ubiquitinated cytosolic proteins to autolysosomes where they were proteolytically converted into products capable of killing M. tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles. Autophagy allows cells to self-digest portions of their own cytoplasm for a multitude of physiological purposes, including innate and adaptive immunity functions. In one of its innate immunity manifestations, autophagy, is known to contribute to the killing of intracellular microbes, includingMycobacterium tuberculosis, although the molecular mechanisms have been unclear. Here, we delineated sequential steps of the autophagic pathway necessary to control intracellularM. tuberculosisand found that in addition to autophagy initiation and maturation, an accessory autophagy-targeting molecule p62 (A170 or SQSTM1) was required for mycobactericidal activity. The p62 adaptor protein delivered specific ribosomal and bulk ubiquitinated cytosolic proteins to autolysosomes where they were proteolytically converted into products capable of killingM. tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles.
Author	Roberts, Esteban A. Deretic, Vojo Dinkins, Christina Zhao, Zijiang Davis, Alexander S. Kyei, George B. Ponpuak, Marisa Vergne, Isabelle Delgado, Monica A. Virgin, Herbert W. Johansen, Terje
Author_xml	– sequence: 1 givenname: Marisa surname: Ponpuak fullname: Ponpuak, Marisa organization: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA – sequence: 2 givenname: Alexander S. surname: Davis fullname: Davis, Alexander S. organization: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA – sequence: 3 givenname: Esteban A. surname: Roberts fullname: Roberts, Esteban A. organization: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA – sequence: 4 givenname: Monica A. surname: Delgado fullname: Delgado, Monica A. organization: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA – sequence: 5 givenname: Christina surname: Dinkins fullname: Dinkins, Christina organization: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA – sequence: 6 givenname: Zijiang surname: Zhao fullname: Zhao, Zijiang organization: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 7 givenname: Herbert W. surname: Virgin fullname: Virgin, Herbert W. organization: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 8 givenname: George B. surname: Kyei fullname: Kyei, George B. organization: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA – sequence: 9 givenname: Terje surname: Johansen fullname: Johansen, Terje organization: Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway – sequence: 10 givenname: Isabelle surname: Vergne fullname: Vergne, Isabelle organization: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA – sequence: 11 givenname: Vojo surname: Deretic fullname: Deretic, Vojo email: vderetic@salud.unm.edu organization: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/20206555$$D View this record in MEDLINE/PubMed
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ContentType	Journal Article
Copyright	2010 Elsevier Inc. Copyright Elsevier Limited Mar 26, 2010
Copyright_xml	– notice: 2010 Elsevier Inc. – notice: Copyright Elsevier Limited Mar 26, 2010
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Snippet	Autophagy allows cells to self-digest portions of their own cytoplasm for a multitude of physiological purposes, including innate and adaptive immunity...
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SubjectTerms	Acidification Adaptor Proteins, Signal Transducing - immunology Animals Antimicrobial agents Autophagy Biological Transport Cells, Cultured Cytosol - immunology Cytosol - metabolism Heat-Shock Proteins - immunology Mice Mice, Inbred C57BL MOLIMMUNO Mycobacterium Mycobacterium tuberculosis - immunology Phagosomes - immunology Phagosomes - metabolism Protein Binding Proteins Sequestosome-1 Protein Ubiquitin - metabolism
Title	Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties
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