Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

• Published in: eLife Vol. 14
• Main Authors: Song, Hyun Beom, Campello, Laura, Mondal, Anupam, Chen, Holly Y, English, Milton A, Glen, Michael, Vanlandingham, Phillip, Farjo, Rafal, Swaroop, Anand
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 15.04.2025; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Animals; Cell death; Cellular stress response; Cilia; Corticosteroids; Disease Models, Animal; Female; Genetic aspects; Health aspects; Leber congenital amaurosis; Male; Medical research; Medicine; Medicine, Experimental; Mutation; neuroprotection; Organoids; Photoreceptors; Phototransduction; Physiological aspects; Proteins; Rats; Research Advance; Reserpine; Reserpine - pharmacology; Reserpine - therapeutic use; Retina; Retinal degeneration; Retinal Rod Photoreceptor Cells - drug effects; Retinitis pigmentosa; Retinitis Pigmentosa - drug therapy; Retinitis Pigmentosa - genetics; Retinitis Pigmentosa - pathology; Rhodopsin; Rhodopsin - genetics; Rhodopsin - metabolism; rhodopsin mutation; Sex Factors; small molecule drug; Tomography; Transcriptomes; Visual acuity; United States; California; retinal degeneration; rat; neuroprotection; rhodopsin mutation; retinitis pigmentosa; medicine; small molecule drug

Inherited retinal degenerations (IRDs) constitute a group of clinically and genetically diverse vision-impairing disorders. Retinitis pigmentosa (RP), the most common form of IRD, is characterized by gradual dysfunction and degeneration of rod photoreceptors, followed by the loss of cone photorecept...