Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa - Song, Hyun Beom; Campello, Laura; Mondal, Anupam; Chen, Holly Y; English, Milton A; Glen, Michael; Vanlandingham, Phillip; Farjo, Rafal; Swaroop, Anand (eLife, 2025)
Keywords: Animals; Cell death; Cellular stress response; Cilia; Corticosteroids; Disease Models, Animal; Female; Genetic aspects; Health aspects; Leber congenital amaurosis; Male; Medical research; Medicine; Medicine, Experimental; Mutation; neuroprotection; Organoids; Photoreceptors; Phototransduction; Physiological aspects; Proteins; Rats; Research Advance; Reserpine; Reserpine - pharmacology; Reserpine - therapeutic use; Retina; Retinal degeneration; Retinal Rod Photoreceptor Cells - drug effects; Retinitis pigmentosa; Retinitis Pigmentosa - drug therapy; Retinitis Pigmentosa - genetics; Retinitis Pigmentosa - pathology; Rhodopsin; Rhodopsin - genetics; Rhodopsin - metabolism; rhodopsin mutation; Sex Factors; small molecule drug; Tomography; Transcriptomes; Visual acuity; United States; California; retinal degeneration; rat; neuroprotection; rhodopsin mutation; retinitis pigmentosa; medicine; small molecule drug