The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence

• Published in: Cell host & microbe Vol. 10; no. 1; pp. 21 - 32
• Main Authors: Jorgensen, Ine, Bednar, Maria M, Amin, Vishar, Davis, Beckley K, Ting, Jenny P Y, McCafferty, Dewey G, Valdivia, Raphael H
• Format: Journal Article
• Language: English
• Published: United States 21.07.2011
• Subjects: Amino Acid Chloromethyl Ketones - pharmacology; Amino Acid Sequence; Animals; Antigens, Bacterial - metabolism; Bacterial Proteins - metabolism; Bacterial Secretion Systems; Caspase 1 - metabolism; Cell Death - physiology; Cell Membrane Permeability; Chlamydia trachomatis - metabolism; Chlamydia trachomatis - pathogenicity; Endopeptidases - metabolism; Epithelial Cells - microbiology; Host-Pathogen Interactions; Mice; Molecular Sequence Data; Peptides - metabolism; Protease Inhibitors - pharmacology; Protein Transport; Virulence Factors - metabolism

The obligate intracellular bacterial pathogen Chlamydia trachomatis injects numerous effector proteins into the epithelial cell cytoplasm to manipulate host functions important for bacterial survival. In addition, the bacterium secretes a serine protease, chlamydial protease-like activity factor (CP...