Dynamic Changes of Th1 Cytokines and the Clinical Significance of the IFN-γ/TNF-α Ratio in Acute Brucellosis

• Published in: Mediators of inflammation Vol. 2019; no. 2019; pp. 1 - 10
• Main Authors: Yang, Mingyuan, Wang, Feng, Jiang, Yanfang, Dang, Rongjing, Zhang, Peng, Xu, Guang, Wang, Bin
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2019; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Adult; Antibiotics; Bacteria; Bacterial infections; Blood; Blood culture; Brucellosis; Brucellosis - immunology; Brucellosis - metabolism; Cell culture; Clinical significance; Cytokines; Cytokines - metabolism; Decision making; Female; Flow Cytometry; Humans; Immune response; Immunization; Immunology; Infections; Infectious diseases; Inflammation; Interferon-gamma - metabolism; Laboratories; Livestock; Lymphocytes; Lymphocytes T; Male; Middle Aged; Patients; Serum levels; Th1 Cells - metabolism; Tuberculosis; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Young Adult; γ-Interferon; United States > US
• ISSN: 0962-9351; 1466-1861; 1466-1861
• DOI: 10.1155/2019/5869257

Background. T-helper type 1 (Th1) cells and Th1-produced cytokines play essential roles in the immune response to foreign pathogens, such as Brucella spp. The aim of this study was to evaluate the dynamic changes of Th1 cells and Th1-produced cytokines in patients with acute brucellosis and their im...