Genome-wide association study for circulating fibroblast growth factor 21 and 23

• Published in: Scientific reports Vol. 10; no. 1; p. 14578
• Main Authors: Chuang, Gwo-Tsann, Liu, Pi-Hua, Chyan, Tsui-Wei, Huang, Chen-Hao, Huang, Yu-Yao, Lin, Chia-Hung, Lin, Jou-Wei, Hsu, Chih-Neng, Tsai, Ru-Yi, Hsieh, Meng-Lun, Lee, Hsiao-Lin, Yang, Wei-Shun, Robinson-Cohen, Cassianne, Hsiung, Chia-Ni, Shen, Chen-Yang, Chang, Yi-Cheng
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 03.09.2020; Nature Publishing Group UK
• Subjects: Adult; Aged; Biomarkers - blood; Body Mass Index; Electron microscopy; Female; Fibroblast Growth Factors - blood; Fibroblast Growth Factors - genetics; Fixatives; Genome-wide association studies; Genome-Wide Association Study; Humans; Male; Microscopy; Middle Aged; Polymorphism, Single Nucleotide; Scanning; Taiwan; Vitamin D - blood; Taiwan

Fibroblast growth factors (FGFs) 21 and 23 are recently identified hormones regulating metabolism of glucose, lipid, phosphate and vitamin D. Here we conducted a genome-wide association study (GWAS) for circulating FGF21 and FGF23 concentrations to identify their genetic determinants. We enrolled 5,...