Developmental competence of oocytes grown in vitro: Has it peaked already?

In vitro growth of immature oocytes provides opportunities to increase gametic resources and to understand the mechanisms underlying oocyte development. Many studies on the in vitro growth of oocytes have been reported thus far; however, only a few cases have been reported, which demonstrated that o...

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Bibliographic Details
Published inJournal of Reproduction and Development Vol. 62; no. 1; pp. 1 - 5
Main Authors MOROHAKU, Kanako, HIRAO, Yuji, OBATA, Yayoi
Format Journal Article
LanguageEnglish
Published Japan THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT 2016
The Society for Reproduction and Development
Subjects
Animals
Culture Media - chemistry
Cytoplasm - metabolism
Female
Fertilization in Vitro
Follicle culture
Germ Cells - cytology
Humans
In vitro growth
Mice
Oocyte competence
Oocytes - cytology
Oogenesis
Opinions and Hypotheses
Organ culture
Organ Culture Techniques - methods
Ovarian Follicle - cytology
Reproductive Medicine - methods
RNA Interference
Transcriptome
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Summary:In vitro growth of immature oocytes provides opportunities to increase gametic resources and to understand the mechanisms underlying oocyte development. Many studies on the in vitro growth of oocytes have been reported thus far; however, only a few cases have been reported, which demonstrated that oocytes can support full-term development after in vitro fertilization. Our research group recently found that culture of mouse neonatal primordial follicles increased the birthrate; however, the establishment of an in vitro system that can completely mimic follicle or oocyte growth in vivo and control oogenesis remains an ongoing challenge.
ISSN:0916-8818
1348-4400
DOI:10.1262/jrd.2015-148