In Silico Stage-Matching of Human, Marmoset, Mouse, and Pig Embryos to Enhance Organ Development Through Interspecies Chimerism

• Published in: Cell transplantation Vol. 32; p. 9636897231158728
• Main Authors: Shetty, Anala, Lim, Seunghyun, Strell, Phoebe, Steer, Clifford J., Rivera-Mulia, Juan Carlos, Low, Walter C.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2023; Sage Publications Ltd
• Subjects: Animals; Blastocyst; Callithrix; Chimerism; Complementation; Correlation analysis; Developmental stages; Embryo, Mammalian; Embryos; Humans; Mice; Organogenesis; Pluripotency; Pluripotent Stem Cells; Rats; Special Collection on Generating Exogenic Organs and Cells for Regenerative Medicine: Science, Ethics, Policy, Public Attitudes, and Law; Species; Stem cell transplantation; Swine; Transcriptomes; correlation analysis; interspecies chimerism; early embryonic development; scRNA-seq analysis; stage-matching

Currently, there is a significant shortage of transplantable organs for patients in need. Interspecies chimerism and blastocyst complementation are alternatives for generating transplantable human organs in host animals such as pigs to meet this shortage. While successful interspecies chimerism and...