Prospective Minimal Residual Disease Monitoring to Predict Relapse of Acute Promyelocytic Leukemia and to Direct Pre-Emptive Arsenic Trioxide Therapy - Grimwade, David; Jovanovic, Jelena V.; Hills, Robert K.; Nugent, Elizabeth A.; Patel, Yashma; Flora, Rajinder; Diverio, Daniela; Jones, Katy; Aslett, Hannah; Batson, Elaine; Rennie, Kristian; Angell, Roger; et al. (Journal of clinical oncology, 2009)
Keywords: Adult; Aged; Arsenic Trioxide; Arsenicals - administration & dosage; Biological and medical sciences; Blood Chemical Analysis; Bone Marrow - pathology; Cohort Studies; Confidence Intervals; Female; Gene Expression Regulation, Neoplastic; Hematologic and hematopoietic diseases; Humans; Leukemia, Promyelocytic, Acute - drug therapy; Leukemia, Promyelocytic, Acute - genetics; Leukemia, Promyelocytic, Acute - mortality; Leukemia, Promyelocytic, Acute - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Monitoring, Physiologic - methods; Multivariate Analysis; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - mortality; Neoplasm, Residual - diagnosis; Neoplasm, Residual - drug therapy; Neoplasm, Residual - genetics; Neoplasm, Residual - mortality; Oncogene Proteins, Fusion - genetics; Oncogene Proteins, Fusion - metabolism; Oxides - administration & dosage; Predictive Value of Tests; Probability; Prognosis; Proportional Hazards Models; Prospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Survival Analysis; Treatment Outcome; Tretinoin - administration & dosage; Tumors; Promyelocytic leukemia; Relapse; Acute; Minimal residual disease; Arsenic trioxide; Malignant hemopathy; Prospective; Prevention; Cancerology; Treatment; Surveillance; Predictive factor; Cancer; M3 acute myelocytic leukemia