mAKAPβ signalosomes – A nodal regulator of gene transcription associated with pathological cardiac remodeling

• Published in: Cellular signalling Vol. 63; p. 109357
• Main Authors: Dodge-Kafka, Kimberly, Gildart, Moriah, Tokarski, Kristin, Kapiloff, Michael S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.11.2019
• Subjects: A Kinase Anchor Proteins - physiology; AKAP; Animals; cAMP; Cardiac hypertrophy; Cardiomegaly - metabolism; Cardiomegaly - pathology; Cell Line; Gene transcription; Histone Deacetylases - metabolism; Humans; Kinase; Mice; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Transcription Factors - metabolism; Ventricular Remodeling; Cardiac hypertrophy; cAMP; Kinase; AKAP; Gene transcription

Striated myocytes compose about half of the cells of the heart, while contributing the majority of the heart's mass and volume. In response to increased demands for pumping power, including in diseases of pressure and volume overload, the contractile myocytes undergo non-mitotic growth, resulti...