Bamboo leaf extract ameliorates diabetic nephropathy through activating the AKT signaling pathway in rats

• Published in: International journal of biological macromolecules Vol. 105; no. Pt 3; pp. 1587 - 1594
• Main Authors: Ying, Changjiang, Mao, Yizhen, Chen, Lei, Wang, Shanshan, Ling, Hongwei, Li, Wei, Zhou, Xiaoyan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2017
• Subjects: abdominal cavity; aldehydes; animal disease models; Animals; B-cell lymphoma; Bamboo leaf extract; bamboos; blood glucose; Blood Glucose - metabolism; blood serum; Body Weight - drug effects; body weight changes; caspase-3; creatinine; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - pathology; diabetic nephropathy; electron microscopy; Glycated Hemoglobin A - metabolism; glycogen (starch) synthase; glycohemoglobin; glycosylation; high fat diet; hyperglycemia; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; leaf extracts; leukemia; Male; methane; microstructure; oral administration; oxidative stress; P-AKT; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Leaves - chemistry; Poaceae - chemistry; protective effect; protein kinases; Proto-Oncogene Proteins c-akt - metabolism; Rats; Rats, Sprague-Dawley; signal transduction; Signal Transduction - drug effects; staining; sugars; superoxide dismutase; ultrastructure; urea nitrogen; weight loss; Western blotting; P-AKT; Bamboo leaf extract; DN

Diabetic nephropathy (DN) is one of the most severe diabetic complication and it is becoming become a worldwide epidemic, accounting for approximately one-third of all case of end-stage renal disease. However, the underlying mechanism and strategy to alleviate renal injury remain unclear. In the pre...