Epigenetic Regulation of E-Cadherin Controls Endometrial Receptivity

• Published in: Endocrinology (Philadelphia) Vol. 150; no. 3; pp. 1466 - 1472
• Main Authors: Rahnama, Fahimeh, Thompson, Bridget, Steiner, Michael, Shafiei, Farhad, Lobie, Peter E, Mitchell, Murray D
• Format: Journal Article
• Language: English
• Published: Chevy Chase, MD Endocrine Society 01.03.2009
• Subjects: Azacitidine - pharmacology; Biological and medical sciences; Cadherins - genetics; Cadherins - physiology; Cell Adhesion - drug effects; Cell Adhesion - genetics; Desmoplakins - genetics; Desmoplakins - metabolism; DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors; DNA Methylation - drug effects; DNA Methylation - physiology; Embryo Implantation - genetics; Endometrium - metabolism; Endometrium - physiology; Enzyme Inhibitors - pharmacology; Epigenesis, Genetic - physiology; Female; Fundamental and applied biological sciences. Psychology; gamma Catenin; Humans; Tumor Cells, Cultured; Vertebrates: endocrinology; Uterus; E Cadherin; Endometrium; Female genital system

Key to the success of human reproduction is the capacity of an embryo to attach and implant into the endometrial wall after which a nutrient supply is established through placentation. Herein, we have examined the potential epigenetic regulation of uterine receptivity by use of the receptive RL95-2...