Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors

The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the g...

Full description

Saved in:
Bibliographic Details
Published inImmune network Vol. 21; no. 3; pp. e20 - 18
Main Authors Gwak, Min-Gyu, Chang, Sun-Young
Format Journal Article
LanguageEnglish
Published The Korean Association of Immunologists 01.06.2021
대한면역학회
Subjects
Review
면역학
Online AccessGet full text

Cover

Abstract The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis.The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis.
AbstractList The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis. KCI Citation Count: 0
The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis.
The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis.The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis.
Author Chang, Sun-Young
Gwak, Min-Gyu
AuthorAffiliation Laboratory of Microbiology, College of Pharmacy, and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon 16499, Korea
AuthorAffiliation_xml – name: Laboratory of Microbiology, College of Pharmacy, and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon 16499, Korea
Author_xml – sequence: 1
  givenname: Min-Gyu
  orcidid: 0000-0001-5700-0499
  surname: Gwak
  fullname: Gwak, Min-Gyu
  organization: Laboratory of Microbiology, College of Pharmacy, and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon 16499, Korea
– sequence: 2
  givenname: Sun-Young
  orcidid: 0000-0001-7336-9245
  surname: Chang
  fullname: Chang, Sun-Young
  organization: Laboratory of Microbiology, College of Pharmacy, and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon 16499, Korea
BackLink https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002737031$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNp1kc1rGzEQxUVwiR0n15z32ELWlbTSrtRDITH5goRAPs5CK82mqnelRFoH-t9XtkOghcDAHOb33jxmDtDEBw8IHRO8YITg784vKKZkkQso3kMziiUt61rwCZoRLkVJayqn6CCl3xjXrGr4PppWjDZNls_Q1eV6LM-idr5YBu_BjC74H8WtMzG0LgxwUmSiONMxOognhfa2OPdvLgY_gB91XzyATyGmQ_Sl032Co_c-R08X54_Lq_Lm7vJ6eXpTGlY3Y9lw3ghpRdN1YIEzYbXtoK07IlpiagGstdxarCW0hHMASXFLmWAGDLe0rubo287Xx06tjFNBu21_DmoV1en947WSohKSsMz-3LEv63YAa3LgqHv1Et2g45-t8t-Jd7-yz5sSeRElVTb4-m4Qw-sa0qgGlwz0vfYQ1klRzitaSU5xRhc7NB8upQjdxxqC1eZVynm1eZXKBVsB-09g3Kg3589RXP-Z7C8UcZmu
CitedBy_id crossref_primary_10_3389_fnut_2025_1426485
crossref_primary_10_1007_s00401_023_02629_2
crossref_primary_10_1016_j_vaccine_2023_01_074
crossref_primary_10_3233_JAD_240524
crossref_primary_10_3390_antiox12040819
crossref_primary_10_1016_j_neuropharm_2023_109505
crossref_primary_10_3389_fnut_2024_1481279
crossref_primary_10_3390_nu16091298
crossref_primary_10_3390_nu16244359
crossref_primary_10_1016_j_neuroscience_2024_11_070
crossref_primary_10_1186_s12974_022_02606_8
crossref_primary_10_3390_microorganisms10091838
crossref_primary_10_3389_fphar_2024_1348297
crossref_primary_10_3390_ijms252011272
crossref_primary_10_1016_j_cbi_2023_110786
crossref_primary_10_3390_microorganisms12030471
crossref_primary_10_1016_j_jff_2025_106661
crossref_primary_10_1016_j_scitotenv_2022_156819
crossref_primary_10_3390_ijms232113328
crossref_primary_10_3389_falgy_2024_1505834
crossref_primary_10_3389_fmed_2023_1161130
crossref_primary_10_3390_ijms232416154
crossref_primary_10_1016_j_envint_2024_108523
crossref_primary_10_3390_gidisord6030039
crossref_primary_10_1128_mra_01218_22
crossref_primary_10_3390_ijms221810134
crossref_primary_10_3390_nu17050842
crossref_primary_10_1016_j_bbr_2023_114574
crossref_primary_10_1016_j_nutres_2024_01_012
crossref_primary_10_3389_fneur_2022_1013083
crossref_primary_10_1007_s11427_024_2759_3
crossref_primary_10_1016_j_neuroscience_2024_11_068
crossref_primary_10_3389_fncel_2021_765217
crossref_primary_10_69709_GenomC_2024_193113
crossref_primary_10_3389_fmicb_2024_1428239
crossref_primary_10_1186_s13578_024_01278_6
crossref_primary_10_1016_j_bbih_2023_100637
crossref_primary_10_1007_s12602_024_10295_3
crossref_primary_10_1016_j_autneu_2024_103176
crossref_primary_10_3390_ijms252212395
crossref_primary_10_3390_antiox13050536
crossref_primary_10_3390_biomedicines12010221
crossref_primary_10_3390_ijms26041742
crossref_primary_10_3390_nu14050949
crossref_primary_10_3390_ani15020234
crossref_primary_10_1016_j_jneuroim_2023_578171
crossref_primary_10_1242_bio_061745
crossref_primary_10_3390_microorganisms10081544
crossref_primary_10_1007_s11910_022_01196_5
crossref_primary_10_3389_fnins_2023_1081347
crossref_primary_10_1016_j_intimp_2022_109659
crossref_primary_10_1016_j_ejpn_2023_11_001
crossref_primary_10_1016_j_xcrm_2024_101754
crossref_primary_10_1080_19490976_2024_2394166
crossref_primary_10_1016_j_jare_2025_03_017
crossref_primary_10_3389_frmbi_2022_994464
crossref_primary_10_3390_biomedicines11092352
crossref_primary_10_3389_fendo_2023_1117259
crossref_primary_10_1016_j_intimp_2025_114216
crossref_primary_10_1021_acsomega_3c04855
crossref_primary_10_1159_000538416
crossref_primary_10_3389_fmicb_2024_1346371
crossref_primary_10_3389_fncel_2024_1429570
crossref_primary_10_3389_fmicb_2023_1118529
crossref_primary_10_14336_AD_2024_1362
crossref_primary_10_1038_s41598_024_59250_w
crossref_primary_10_3390_applbiosci2010005
crossref_primary_10_1016_j_jhazmat_2023_131820
crossref_primary_10_31083_j_jin2204092
crossref_primary_10_1016_j_ejphar_2024_177080
Cites_doi 10.2174/156652408784533760
10.1016/j.biochi.2018.06.008
10.1016/j.cell.2016.05.018
10.1016/j.neuroscience.2010.08.005
10.1007/s12272-021-01327-5
10.1097/01.mpg.0000226376.95623.9f
10.1007/s11064-010-0187-2
10.1016/j.chom.2018.11.002
10.1126/science.aah5825
10.1016/j.bbi.2007.08.009
10.1016/j.biopsych.2008.06.026
10.1053/j.gastro.2004.03.013
10.1016/j.physbeh.2006.06.019
10.1523/JNEUROSCI.1359-19.2019
10.1096/fj.201901333R
10.1016/j.neuron.2018.11.018
10.1523/JNEUROSCI.1114-16.2016
10.1016/j.cell.2013.11.024
10.1038/nature06881
10.1186/s12974-019-1434-3
10.1177/1098612X17729626
10.1161/CIRCRESAHA.119.316448
10.1186/s12974-019-1572-7
10.3389/fnut.2015.00023
10.1038/s41586-019-1644-y
10.1016/j.immuni.2013.08.003
10.4110/in.2020.20.e15
10.1038/s41579-020-00460-0
10.1126/scitranslmed.3009759
10.1038/nm.4068
10.1007/s00428-009-0879-7
10.1073/pnas.0805323106
10.1016/j.cell.2016.11.018
10.1053/j.gastro.2017.05.003
10.1038/ncomms11639
10.1038/s41577-019-0125-8
10.1113/jphysiol.2004.063388
10.1038/s41598-018-28048-y
10.1136/gut.2006.117176
10.1038/s41575-019-0157-3
10.1038/nature07935
10.1016/j.psyneuen.2012.03.024
10.1056/NEJMoa1804492
10.1093/toxsci/kfr249
10.1016/j.jneuroim.2016.06.003
10.1038/mi.2017.73
10.3389/fmicb.2014.00146
10.1038/nm.4194
10.1084/jem.20180794
10.1038/nm.4106
10.1073/pnas.1322269111
10.1016/j.coph.2011.02.004
10.1038/s41586-018-0119-x
10.1136/gutjnl-2020-323263
10.1083/jcb.200307111
10.4110/in.2020.20.e44
10.1016/j.brainresbull.2019.09.003
10.1016/j.immuni.2013.08.002
10.1038/nature12721
10.1016/j.freeradbiomed.2014.02.003
10.1038/nrgastro.2013.105
10.7150/ijbs.22259
10.1038/mi.2016.133
10.3389/fendo.2020.00025
10.1007/s10522-012-9406-3
10.1038/nn.4030
10.1038/s12276-018-0126-x
10.1038/ajg.2010.90
10.1016/j.immuni.2018.07.010
10.1097/MED.0b013e32834190b5
10.1097/MOG.0b013e328365d37c
10.1007/978-1-4939-0897-4_1
10.1161/STROKEAHA.120.029262
10.1038/srep26091
10.1038/mi.2017.118
10.1126/science.1234852
10.1038/ni.2187
10.1073/pnas.1607843113
10.1016/j.celrep.2018.11.055
10.1146/annurev-physiol-021115-105439
10.1016/j.immuni.2011.11.011
ContentType Journal Article
Copyright Copyright © 2021. The Korean Association of Immunologists.
Copyright © 2021. The Korean Association of Immunologists 2021 The Korean Association of Immunologists
Copyright_xml – notice: Copyright © 2021. The Korean Association of Immunologists.
– notice: Copyright © 2021. The Korean Association of Immunologists 2021 The Korean Association of Immunologists
DBID AAYXX
CITATION
7X8
5PM
ACYCR
DOI 10.4110/in.2021.21.e20
DatabaseName CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
Korean Citation Index
DatabaseTitle CrossRef
MEDLINE - Academic
DatabaseTitleList

MEDLINE - Academic
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2092-6685
EndPage 18
ExternalDocumentID oai_kci_go_kr_ARTI_9838914
PMC8263213
10_4110_in_2021_21_e20
GrantInformation_xml – fundername: ;
  grantid: NRF-2020R1A2B5B01001690
GroupedDBID 5-W
53G
8JR
8XY
9ZL
AAYXX
ACYCR
ADBBV
ADRAZ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
CITATION
DBRKI
DIK
E3Z
EF.
F5P
GW5
HYE
KQ8
KVFHK
M48
MZR
O5R
O5S
OK1
PGMZT
RPM
TDB
ZZE
7X8
5PM
.UV
M~E
ID FETCH-LOGICAL-c467t-755789d87ffede548dadfeb6f18b1c68e4bd5dd0a9eb155ee920b2484cec5d263
IEDL.DBID M48
ISSN 1598-2629
IngestDate Tue Nov 21 21:45:18 EST 2023
Thu Aug 21 18:17:24 EDT 2025
Fri Jul 11 03:30:09 EDT 2025
Tue Jul 01 00:45:54 EDT 2025
Thu Apr 24 23:10:43 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c467t-755789d87ffede548dadfeb6f18b1c68e4bd5dd0a9eb155ee920b2484cec5d263
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
https://www.immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e20
ORCID 0000-0001-7336-9245
0000-0001-5700-0499
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.4110/in.2021.21.e20
PMID 34277110
PQID 2553239520
PQPubID 23479
PageCount 18
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_9838914
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8263213
proquest_miscellaneous_2553239520
crossref_primary_10_4110_in_2021_21_e20
crossref_citationtrail_10_4110_in_2021_21_e20
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2021-06-01
PublicationDateYYYYMMDD 2021-06-01
PublicationDate_xml – month: 06
  year: 2021
  text: 2021-06-01
  day: 01
PublicationDecade 2020
PublicationTitle Immune network
PublicationYear 2021
Publisher The Korean Association of Immunologists
대한면역학회
Publisher_xml – name: The Korean Association of Immunologists
– name: 대한면역학회
References Silva (10.4110/in.2021.21.e20_ref24) 2020; 11
Bravo-Ferrer (10.4110/in.2021.21.e20_ref35) 2019; 33
Pedersen (10.4110/in.2021.21.e20_ref57) 2018; 20
Lee (10.4110/in.2021.21.e20_ref66) 2011; 13
Gareau (10.4110/in.2021.21.e20_ref46) 2007; 56
Zelante (10.4110/in.2021.21.e20_ref77) 2013; 39
Sato (10.4110/in.2021.21.e20_ref7) 2009; 459
Metidji (10.4110/in.2021.21.e20_ref59) 2018; 49
Nozawa (10.4110/in.2021.21.e20_ref28) 2009; 106
Qiu (10.4110/in.2021.21.e20_ref67) 2012; 36
Rothhammer (10.4110/in.2021.21.e20_ref69) 2016; 22
Zhao (10.4110/in.2021.21.e20_ref80) 2018; 11
Seo (10.4110/in.2021.21.e20_ref3) 2021; 44
Carabotti (10.4110/in.2021.21.e20_ref12) 2015; 28
García-Ródenas (10.4110/in.2021.21.e20_ref42) 2006; 43
Benakis (10.4110/in.2021.21.e20_ref53) 2020; 51
Docherty (10.4110/in.2021.21.e20_ref32) 2010; 105
Gribble (10.4110/in.2021.21.e20_ref1) 2016; 78
Morais (10.4110/in.2021.21.e20_ref11) 2021; 19
Pinto-Sanchez (10.4110/in.2021.21.e20_ref36) 2017; 153
Coates (10.4110/in.2021.21.e20_ref31) 2004; 126
Kim (10.4110/in.2021.21.e20_ref2) 2020; 20
Brandstätter (10.4110/in.2021.21.e20_ref65) 2016; 6
Rothhammer (10.4110/in.2021.21.e20_ref70) 2018; 557
Szakál (10.4110/in.2021.21.e20_ref5) 2010; 456
Lyte (10.4110/in.2021.21.e20_ref23) 2014; 817
Sudo (10.4110/in.2021.21.e20_ref41) 2004; 558
Lee (10.4110/in.2021.21.e20_ref85) 2020; 127
Desbonnet (10.4110/in.2021.21.e20_ref22) 2010; 170
Abdel-Haq (10.4110/in.2021.21.e20_ref17) 2019; 216
Goehler (10.4110/in.2021.21.e20_ref48) 2008; 22
Worthington (10.4110/in.2021.21.e20_ref16) 2018; 11
Barden (10.4110/in.2021.21.e20_ref40) 2004; 29
Cervantes-Barragan (10.4110/in.2021.21.e20_ref63) 2017; 357
Ait-Belgnaoui (10.4110/in.2021.21.e20_ref47) 2012; 37
Sampson (10.4110/in.2021.21.e20_ref38) 2016; 167
Kaye (10.4110/in.2021.21.e20_ref75) 2016; 113
Chang (10.4110/in.2021.21.e20_ref83) 2014; 111
El Aidy (10.4110/in.2021.21.e20_ref21) 2014; 5
Chelakkot (10.4110/in.2021.21.e20_ref4) 2018; 50
Gareau (10.4110/in.2021.21.e20_ref45) 2008; 8
Sgritta (10.4110/in.2021.21.e20_ref34) 2019; 101
Furusawa (10.4110/in.2021.21.e20_ref82) 2013; 504
Spreckley (10.4110/in.2021.21.e20_ref15) 2015; 2
Hsiao (10.4110/in.2021.21.e20_ref37) 2013; 155
Sadler (10.4110/in.2021.21.e20_ref84) 2020; 40
Benakis (10.4110/in.2021.21.e20_ref54) 2016; 22
Ahern (10.4110/in.2021.21.e20_ref29) 2011; 11
GBD 2016 Lifetime Risk of Stroke Collaborators (10.4110/in.2021.21.e20_ref50) 2018; 379
Kadowaki (10.4110/in.2021.21.e20_ref64) 2016; 7
Di Giaimo (10.4110/in.2021.21.e20_ref74) 2018; 25
Singh (10.4110/in.2021.21.e20_ref51) 2016; 36
Banskota (10.4110/in.2021.21.e20_ref26) 2019; 161
Amoo (10.4110/in.2021.21.e20_ref20) 2021
Benson (10.4110/in.2021.21.e20_ref62) 2011; 124
Fidalgo (10.4110/in.2021.21.e20_ref27) 2013; 14
Rothhammer (10.4110/in.2021.21.e20_ref58) 2019; 19
Kaiko (10.4110/in.2021.21.e20_ref9) 2016; 165
Yu (10.4110/in.2021.21.e20_ref61) 2018; 14
Chen (10.4110/in.2021.21.e20_ref79) 2020; 20
Dalile (10.4110/in.2021.21.e20_ref78) 2019; 16
Braniste (10.4110/in.2021.21.e20_ref19) 2014; 6
Mawe (10.4110/in.2021.21.e20_ref25) 2013; 10
Huang (10.4110/in.2021.21.e20_ref52) 2019; 153
Chen (10.4110/in.2021.21.e20_ref72) 2019; 16
Ma (10.4110/in.2021.21.e20_ref13) 2019; 16
Lee (10.4110/in.2021.21.e20_ref10) 2018; 24
Qiu (10.4110/in.2021.21.e20_ref68) 2013; 39
Kelly (10.4110/in.2021.21.e20_ref44) 2015; 9
Brouns (10.4110/in.2021.21.e20_ref73) 2010; 35
Sato (10.4110/in.2021.21.e20_ref8) 2013; 340
O'Mahony (10.4110/in.2021.21.e20_ref43) 2009; 65
Stanley (10.4110/in.2021.21.e20_ref55) 2016; 22
Chu (10.4110/in.2021.21.e20_ref39) 2019; 574
Erny (10.4110/in.2021.21.e20_ref18) 2015; 18
Veldhoen (10.4110/in.2021.21.e20_ref71) 2008; 453
Berg (10.4110/in.2021.21.e20_ref76) 2016; 298
Gutierrez-Aguilar (10.4110/in.2021.21.e20_ref14) 2011; 18
D'Alessio (10.4110/in.2021.21.e20_ref33) 2013; 29
Xu (10.4110/in.2021.21.e20_ref56) 2021
Lanis (10.4110/in.2021.21.e20_ref60) 2017; 10
Davis (10.4110/in.2021.21.e20_ref6) 2003; 163
Regmi (10.4110/in.2021.21.e20_ref30) 2014; 69
Lyte (10.4110/in.2021.21.e20_ref49) 2006; 89
Martin-Gallausiaux (10.4110/in.2021.21.e20_ref81) 2018; 8
References_xml – volume: 8
  start-page: 274
  year: 2008
  ident: 10.4110/in.2021.21.e20_ref45
  publication-title: Curr Mol Med
  doi: 10.2174/156652408784533760
– volume: 161
  start-page: 56
  year: 2019
  ident: 10.4110/in.2021.21.e20_ref26
  publication-title: Biochimie
  doi: 10.1016/j.biochi.2018.06.008
– volume: 165
  start-page: 1708
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref9
  publication-title: Cell
  doi: 10.1016/j.cell.2016.05.018
– volume: 170
  start-page: 1179
  year: 2010
  ident: 10.4110/in.2021.21.e20_ref22
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.08.005
– volume: 44
  start-page: 325
  year: 2021
  ident: 10.4110/in.2021.21.e20_ref3
  publication-title: Arch Pharm Res
  doi: 10.1007/s12272-021-01327-5
– volume: 43
  start-page: 16
  year: 2006
  ident: 10.4110/in.2021.21.e20_ref42
  publication-title: J Pediatr Gastroenterol Nutr
  doi: 10.1097/01.mpg.0000226376.95623.9f
– volume: 35
  start-page: 1315
  year: 2010
  ident: 10.4110/in.2021.21.e20_ref73
  publication-title: Neurochem Res
  doi: 10.1007/s11064-010-0187-2
– volume: 28
  start-page: 203
  year: 2015
  ident: 10.4110/in.2021.21.e20_ref12
  publication-title: Ann Gastroenterol
– volume: 24
  start-page: 833
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref10
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2018.11.002
– volume: 357
  start-page: 806
  year: 2017
  ident: 10.4110/in.2021.21.e20_ref63
  publication-title: Science
  doi: 10.1126/science.aah5825
– volume: 22
  start-page: 354
  year: 2008
  ident: 10.4110/in.2021.21.e20_ref48
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2007.08.009
– volume: 65
  start-page: 263
  year: 2009
  ident: 10.4110/in.2021.21.e20_ref43
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2008.06.026
– volume: 126
  start-page: 1657
  year: 2004
  ident: 10.4110/in.2021.21.e20_ref31
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2004.03.013
– volume: 89
  start-page: 350
  year: 2006
  ident: 10.4110/in.2021.21.e20_ref49
  publication-title: Physiol Behav
  doi: 10.1016/j.physbeh.2006.06.019
– volume: 40
  start-page: 1162
  year: 2020
  ident: 10.4110/in.2021.21.e20_ref84
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1359-19.2019
– volume: 33
  start-page: 12644
  year: 2019
  ident: 10.4110/in.2021.21.e20_ref35
  publication-title: FASEB J
  doi: 10.1096/fj.201901333R
– volume: 101
  start-page: 246
  year: 2019
  ident: 10.4110/in.2021.21.e20_ref34
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.11.018
– volume: 36
  start-page: 7428
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref51
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1114-16.2016
– volume: 155
  start-page: 1451
  year: 2013
  ident: 10.4110/in.2021.21.e20_ref37
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.024
– volume: 453
  start-page: 106
  year: 2008
  ident: 10.4110/in.2021.21.e20_ref71
  publication-title: Nature
  doi: 10.1038/nature06881
– volume: 16
  start-page: 53
  year: 2019
  ident: 10.4110/in.2021.21.e20_ref13
  publication-title: J Neuroinflammation
  doi: 10.1186/s12974-019-1434-3
– volume: 20
  start-page: 378
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref57
  publication-title: J Feline Med Surg
  doi: 10.1177/1098612X17729626
– volume: 127
  start-page: 453
  year: 2020
  ident: 10.4110/in.2021.21.e20_ref85
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.119.316448
– volume: 16
  start-page: 187
  year: 2019
  ident: 10.4110/in.2021.21.e20_ref72
  publication-title: J Neuroinflammation
  doi: 10.1186/s12974-019-1572-7
– volume: 2
  start-page: 23
  year: 2015
  ident: 10.4110/in.2021.21.e20_ref15
  publication-title: Front Nutr
  doi: 10.3389/fnut.2015.00023
– volume: 574
  start-page: 543
  year: 2019
  ident: 10.4110/in.2021.21.e20_ref39
  publication-title: Nature
  doi: 10.1038/s41586-019-1644-y
– year: 2021
  ident: 10.4110/in.2021.21.e20_ref20
  publication-title: J Neurotrauma
– volume: 39
  start-page: 372
  year: 2013
  ident: 10.4110/in.2021.21.e20_ref77
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.08.003
– volume: 20
  start-page: e15
  year: 2020
  ident: 10.4110/in.2021.21.e20_ref79
  publication-title: Immune Netw
  doi: 10.4110/in.2020.20.e15
– volume: 19
  start-page: 241
  year: 2021
  ident: 10.4110/in.2021.21.e20_ref11
  publication-title: Nat Rev Microbiol
  doi: 10.1038/s41579-020-00460-0
– volume: 6
  start-page: 263ra158
  year: 2014
  ident: 10.4110/in.2021.21.e20_ref19
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3009759
– volume: 22
  start-page: 516
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref54
  publication-title: Nat Med
  doi: 10.1038/nm.4068
– volume: 456
  start-page: 245
  year: 2010
  ident: 10.4110/in.2021.21.e20_ref5
  publication-title: Virchows Arch
  doi: 10.1007/s00428-009-0879-7
– volume: 106
  start-page: 3408
  year: 2009
  ident: 10.4110/in.2021.21.e20_ref28
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0805323106
– volume: 167
  start-page: 1469
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref38
  publication-title: Cell
  doi: 10.1016/j.cell.2016.11.018
– volume: 153
  start-page: 448
  year: 2017
  ident: 10.4110/in.2021.21.e20_ref36
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2017.05.003
– volume: 7
  start-page: 11639
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref64
  publication-title: Nat Commun
  doi: 10.1038/ncomms11639
– volume: 19
  start-page: 184
  year: 2019
  ident: 10.4110/in.2021.21.e20_ref58
  publication-title: Nat Rev Immunol
  doi: 10.1038/s41577-019-0125-8
– volume: 558
  start-page: 263
  year: 2004
  ident: 10.4110/in.2021.21.e20_ref41
  publication-title: J Physiol
  doi: 10.1113/jphysiol.2004.063388
– volume: 8
  start-page: 9742
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref81
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-28048-y
– volume: 56
  start-page: 1522
  year: 2007
  ident: 10.4110/in.2021.21.e20_ref46
  publication-title: Gut
  doi: 10.1136/gut.2006.117176
– volume: 16
  start-page: 461
  year: 2019
  ident: 10.4110/in.2021.21.e20_ref78
  publication-title: Nat Rev Gastroenterol Hepatol
  doi: 10.1038/s41575-019-0157-3
– volume: 459
  start-page: 262
  year: 2009
  ident: 10.4110/in.2021.21.e20_ref7
  publication-title: Nature
  doi: 10.1038/nature07935
– volume: 37
  start-page: 1885
  year: 2012
  ident: 10.4110/in.2021.21.e20_ref47
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2012.03.024
– volume: 9
  start-page: 392
  year: 2015
  ident: 10.4110/in.2021.21.e20_ref44
  publication-title: Front Cell Neurosci
– volume: 379
  start-page: 2429
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref50
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1804492
– volume: 124
  start-page: 327
  year: 2011
  ident: 10.4110/in.2021.21.e20_ref62
  publication-title: Toxicol Sci
  doi: 10.1093/toxsci/kfr249
– volume: 298
  start-page: 9
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref76
  publication-title: J Neuroimmunol
  doi: 10.1016/j.jneuroim.2016.06.003
– volume: 11
  start-page: 3
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref16
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2017.73
– volume: 5
  start-page: 146
  year: 2014
  ident: 10.4110/in.2021.21.e20_ref21
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2014.00146
– volume: 22
  start-page: 1277
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref55
  publication-title: Nat Med
  doi: 10.1038/nm.4194
– volume: 216
  start-page: 41
  year: 2019
  ident: 10.4110/in.2021.21.e20_ref17
  publication-title: J Exp Med
  doi: 10.1084/jem.20180794
– volume: 22
  start-page: 586
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref69
  publication-title: Nat Med
  doi: 10.1038/nm.4106
– volume: 111
  start-page: 2247
  year: 2014
  ident: 10.4110/in.2021.21.e20_ref83
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1322269111
– volume: 11
  start-page: 29
  year: 2011
  ident: 10.4110/in.2021.21.e20_ref29
  publication-title: Curr Opin Pharmacol
  doi: 10.1016/j.coph.2011.02.004
– volume: 557
  start-page: 724
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref70
  publication-title: Nature
  doi: 10.1038/s41586-018-0119-x
– start-page: gutjnl-2020-323263
  year: 2021
  ident: 10.4110/in.2021.21.e20_ref56
  publication-title: Gut
  doi: 10.1136/gutjnl-2020-323263
– volume: 163
  start-page: 525
  year: 2003
  ident: 10.4110/in.2021.21.e20_ref6
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200307111
– volume: 20
  start-page: e44
  year: 2020
  ident: 10.4110/in.2021.21.e20_ref2
  publication-title: Immune Netw
  doi: 10.4110/in.2020.20.e44
– volume: 153
  start-page: 232
  year: 2019
  ident: 10.4110/in.2021.21.e20_ref52
  publication-title: Brain Res Bull
  doi: 10.1016/j.brainresbull.2019.09.003
– volume: 39
  start-page: 386
  year: 2013
  ident: 10.4110/in.2021.21.e20_ref68
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.08.002
– volume: 504
  start-page: 446
  year: 2013
  ident: 10.4110/in.2021.21.e20_ref82
  publication-title: Nature
  doi: 10.1038/nature12721
– volume: 69
  start-page: 377
  year: 2014
  ident: 10.4110/in.2021.21.e20_ref30
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2014.02.003
– volume: 10
  start-page: 473
  year: 2013
  ident: 10.4110/in.2021.21.e20_ref25
  publication-title: Nat Rev Gastroenterol Hepatol
  doi: 10.1038/nrgastro.2013.105
– volume: 14
  start-page: 69
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref61
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.22259
– volume: 10
  start-page: 1133
  year: 2017
  ident: 10.4110/in.2021.21.e20_ref60
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2016.133
– volume: 11
  start-page: 25
  year: 2020
  ident: 10.4110/in.2021.21.e20_ref24
  publication-title: Front Endocrinol (Lausanne)
  doi: 10.3389/fendo.2020.00025
– volume: 14
  start-page: 21
  year: 2013
  ident: 10.4110/in.2021.21.e20_ref27
  publication-title: Biogerontology
  doi: 10.1007/s10522-012-9406-3
– volume: 18
  start-page: 965
  year: 2015
  ident: 10.4110/in.2021.21.e20_ref18
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4030
– volume: 50
  start-page: 1
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref4
  publication-title: Exp Mol Med
  doi: 10.1038/s12276-018-0126-x
– volume: 105
  start-page: 1449
  year: 2010
  ident: 10.4110/in.2021.21.e20_ref32
  publication-title: Am J Gastroenterol
  doi: 10.1038/ajg.2010.90
– volume: 49
  start-page: 353
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref59
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.07.010
– volume: 18
  start-page: 35
  year: 2011
  ident: 10.4110/in.2021.21.e20_ref14
  publication-title: Curr Opin Endocrinol Diabetes Obes
  doi: 10.1097/MED.0b013e32834190b5
– volume: 29
  start-page: 608
  year: 2013
  ident: 10.4110/in.2021.21.e20_ref33
  publication-title: Curr Opin Gastroenterol
  doi: 10.1097/MOG.0b013e328365d37c
– volume: 817
  start-page: 3
  year: 2014
  ident: 10.4110/in.2021.21.e20_ref23
  publication-title: Adv Exp Med Biol
  doi: 10.1007/978-1-4939-0897-4_1
– volume: 51
  start-page: 1844
  year: 2020
  ident: 10.4110/in.2021.21.e20_ref53
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.120.029262
– volume: 6
  start-page: 26091
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref65
  publication-title: Sci Rep
  doi: 10.1038/srep26091
– volume: 11
  start-page: 752
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref80
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2017.118
– volume: 340
  start-page: 1190
  year: 2013
  ident: 10.4110/in.2021.21.e20_ref8
  publication-title: Science
  doi: 10.1126/science.1234852
– volume: 13
  start-page: 144
  year: 2011
  ident: 10.4110/in.2021.21.e20_ref66
  publication-title: Nat Immunol
  doi: 10.1038/ni.2187
– volume: 113
  start-page: E6145
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref75
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1607843113
– volume: 29
  start-page: 185
  year: 2004
  ident: 10.4110/in.2021.21.e20_ref40
  publication-title: J Psychiatry Neurosci
– volume: 25
  start-page: 3241
  year: 2018
  ident: 10.4110/in.2021.21.e20_ref74
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2018.11.055
– volume: 78
  start-page: 277
  year: 2016
  ident: 10.4110/in.2021.21.e20_ref1
  publication-title: Annu Rev Physiol
  doi: 10.1146/annurev-physiol-021115-105439
– volume: 36
  start-page: 92
  year: 2012
  ident: 10.4110/in.2021.21.e20_ref67
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.11.011
SSID ssj0064375
Score 2.4427266
SecondaryResourceType review_article
Snippet The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with...
SourceID nrf
pubmedcentral
proquest
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage e20
SubjectTerms Review
면역학
Title Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors
URI https://www.proquest.com/docview/2553239520
https://pubmed.ncbi.nlm.nih.gov/PMC8263213
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002737031
Volume 21
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Immune Network, 2021, 21(3), , pp.1-18
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3di9QwEA96IvgifuL6cVQRfLmszXfji3hy5yqsL7pwbyFpJlru7Gp3F7z_3km7t2fhBKHQh07TMPmYmc7k9yPkZZnKpKWRVHsWqGTJ0KBSResQuAWmvIZ83nn-Wc8W8tOJOrmsf9oqcHVlaJf5pBbd2fT3r_O3uODRf51KtF6vm4xjyjHYY1PgGL7fQKtkMpvBXO4yCjk_pXrsVIszQ3M7ADhe8f7IQF1vuzTyPceVk3-ZouM75PbWhyzeDYN-l1yD9h65ObBKnt8nsw-bNT3M1A9FX8bSn1x4U8ybAXPpBxwUKFEc-i6z1R0Uvo3F0eV5N2z5C8a2y271gCyOj76-n9EtYQKtcb9bU6Nw_dlYmZQgAsYi0ccEQSdWBVbrCmSIKsbSW9yhlQKwvAxcVrKGWkWuxUOy1y5beEQKKGsdTQ2aMSGjASs8erbCBGa88FxMCL3Qkqu3aOKZ1OLMYVSRteqa1mWtOrxQqxPyaif_c8DR-KfkC1S6O60bl6Gv8_3b0p12Dh38j85WObEqJ-T5xZg4XA85yeFbWG5WDkMkwYVVuSEzGqzdd3Oz4ydt871H1q4yej0Tj_-nC0_IrdzroWzsKdlbdxt4hg7KOuz3M2-__3P0BzE75dc
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Gut-Brain+Connection%3A+Microbiome%2C+Gut+Barrier%2C+and+Environmental+Sensors&rft.jtitle=Immune+network&rft.au=%EA%B3%BD%EB%AF%BC%EA%B7%9C&rft.au=%EC%9E%A5%EC%84%A0%EC%98%81&rft.date=2021-06-01&rft.pub=%EB%8C%80%ED%95%9C%EB%A9%B4%EC%97%AD%ED%95%99%ED%9A%8C&rft.issn=1598-2629&rft.eissn=2092-6685&rft.spage=1&rft.epage=18&rft_id=info:doi/10.4110%2Fin.2021.21.e20&rft.externalDBID=n%2Fa&rft.externalDocID=oai_kci_go_kr_ARTI_9838914
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1598-2629&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1598-2629&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1598-2629&client=summon