Protective Effect and Mechanism of Total Flavones from Rhododendron simsii Planch on Endothelium-Dependent Dilatation and Hyperpolarization in Cerebral Ischemia-Reperfusion and Correlation to Hydrogen Sulphide Release in Rats

• Published in: Evidence-based complementary and alternative medicine Vol. 2014; no. 2014; pp. 1 - 11
• Main Authors: Han, Jun, Chen, Zhi-Wu, He, Guo-Wei
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2014; John Wiley & Sons, Inc
• Subjects: Arginine; Brain injury; Calcium; Cerebrum; Coronary vessels; Endothelial cells; Endothelium; Flavones; Flavonoids; Free radicals; Gene expression; Hydrogen; Hydrogen sulfide; Hyperpolarization; Indomethacin; Ischemia; Laboratory animals; Medicine; Nitric oxide; Pharmacology; Reperfusion; Rhododendron; Rodents; Smooth muscle; Vasodilation; Veins & arteries; United States > US; China

We for the first time investigated the effect and mechanism of the total flavones of Rhododendron simsii Planch (TFR), a widely-used Chinese herb for a thousand years, on vasodilatation and hyperpolarization in middle cerebral artery (MCA) of rats subject to global cerebral ischemia-reperfusion (CIR...