Plasma Biomarker Profiles Differ Depending on Breast Cancer Subtype but RANTES Is Consistently Increased

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 20; no. 7; pp. 1543 - 1551
• Main Authors: Gonzalez, Rachel M., Daly, Don S., Tan, Ruimin, Marks, Jeffrey R., Zangar, Richard C.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.07.2011
• Subjects: 60 APPLIED LIFE SCIENCES; ACCURACY; Area Under Curve; BASIC BIOLOGICAL SCIENCES; Biological and medical sciences; BIOLOGICAL MARKERS; Biomarkers, Tumor - blood; BIOPSY; Breast Neoplasms - blood; Breast Neoplasms - pathology; CELL-LINES; Chemokine CCL5 - blood; DETECTION; DISEASES; Enzyme-Linked Immunosorbent Assay; ESTROGEN; ESTROGENS; FEATURES; Female; GENE-EXPRESSION PATTERNS; GROWTH FACTORS; Gynecology. Andrology. Obstetrics; Humans; LIGANDS; LYMPHOKINES; Mammary gland diseases; MAMMARY GLANDS; MAMMOGRAPHY; Medical sciences; MICROARRAYS; MOLECULAR SUBTYPES; NEOPLASMS; PLASMA; Protein Array Analysis; PROTEINS; ROC Curve; Sensitivity and Specificity; TUMOR SUBTYPES; Tumors; Breast disease; RANTES; Biological marker; Biological indicator; Breast cancer; CC chemokine; Malignant tumor; Blood plasma; Mammary gland diseases; Cancerology; Mammary gland; Subtype; Cancer
• ISSN: 1055-9965; 1538-7755; 1538-7755
• DOI: 10.1158/1055-9965.EPI-10-1248

Background: Current biomarkers for breast cancer have little potential for detection. We determined whether breast cancer subtypes influence circulating protein biomarkers. Methods: A sandwich ELISA microarray platform was used to evaluate 23 candidate biomarkers in plasma samples that were obtained...