Intranasal immunization with inactivated tick-borne encephalitis virus and the antigenic peptide 89–119 protects mice against intraperitoneal challenge

• Published in: International journal of medical microbiology Vol. 296; pp. 195 - 201
• Main Authors: Goncharova, Elena, Ryzhikov, Evgeny, Poryvaev, Vasily, Bulychev, Leonid, Karpyshev, Nikolay, Maksyutov, Amir, Ryzhikov, Alexander B.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.05.2006
• Subjects: Administration, Intranasal; Amino Acid Sequence; Animals; Antigenic peptide; Encephalitis Viruses, Tick-Borne - immunology; Encephalitis, Tick-Borne - immunology; Encephalitis, Tick-Borne - prevention & control; Immunoglobulin G - blood; Injections, Intraperitoneal; Intranasal immunization; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Nanoemulsion; Peptide Fragments - immunology; Protection; Tick-borne encephalitis virus; Viral Envelope Proteins - immunology; Viral Vaccines - administration & dosage; Intranasal immunization; Tick-borne encephalitis virus; Antigenic peptide; Protection; Nanoemulsion

Detailed studies of the pathogenesis of certain neuroviral infections allow for a better understanding of the special role of the olfactory neuroepithelial cells in the invasion of viruses into the CNS. Several studies using animal models demonstrated that neurotropic viruses belonging to various fa...