Hypromellose acetate succinate based amorphous solid dispersions via hot melt extrusion: Effect of drug physicochemical properties
•Amorphous solid dispersions were prepared using HPMCAS via hot melt extrusion.•NFD was solubilized better by HPMCAS grades compared to EFZ.•Drug physicochemical properties affected the dissolution efficiency of polymer.•Substitutions on polymer grade has significant effect on supersaturation mainte...
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Published in | Carbohydrate polymers Vol. 233; p. 115828 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.04.2020
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Subjects | |
Online Access | Get full text |
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