Hypromellose acetate succinate based amorphous solid dispersions via hot melt extrusion: Effect of drug physicochemical properties

• Published in: Carbohydrate polymers Vol. 233; p. 115828
• Main Authors: Sarabu, Sandeep, Kallakunta, Venkata Raman, Bandari, Suresh, Batra, Amol, Bi, Vivian, Durig, Thomas, Zhang, Feng, Repka, Michael A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2020
• Subjects: Acetates - chemistry; Alkynes; Benzoxazines - chemistry; Cyclopropanes; Drug Compounding - methods; Drug Liberation; Drug Stability; Efavirenz; Excipients - chemistry; HME; Hot Melt Extrusion Technology; Hot Temperature; HPMCAS; Hypromellose Derivatives - chemistry; Methylcellulose - analogs & derivatives; Methylcellulose - chemistry; Nifedipine; Nifedipine - chemistry; Solid dispersions; Solubility; Succinates - chemistry; Supersaturation; HPMCAS; HME; Supersaturation; Solid dispersions; Efavirenz; Nifedipine

•Amorphous solid dispersions were prepared using HPMCAS via hot melt extrusion.•NFD was solubilized better by HPMCAS grades compared to EFZ.•Drug physicochemical properties affected the dissolution efficiency of polymer.•Substitutions on polymer grade has significant effect on supersaturation mainte...