Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation

• Published in: Biological research Vol. 46; no. 4; pp. 441 - 451
• Main Authors: Montoya, Fredy, Martínez, Fernando, García-Robles, María, Balmaceda-Aguilera, Carolina, Koch, Ximena, Rodríguez, Federico, Silva-Álvarez, Carmen, Salazar, Katterine, Ulloa, Viviana, Nualart, Francisco
• Format: Journal Article
• Language: English; Portuguese
• Published: England Sociedad de Biología de Chile 2013; BMC
• Subjects: BIOLOGY; Cartilage; Cartilage, Articular - injuries; Cell Differentiation; Chondrocytes - cytology; Chondrocytes - transplantation; Humans; Knee Injuries - pathology; Knee Injuries - rehabilitation; lesion; Mesenchymal Stem Cell Transplantation - methods; microfracture; Regeneration - physiology; stem cells; Tissue Engineering; microfracture; Cartilage; stem cells; lesion

Cartilage has poor regeneration capacity due to the scarcity of endogenous stem cells, its low metabolic activity and the avascular environment. Repair strategies vary widely, including microfracture, autologous or allogenic tissue implantation, and in vitro engineered tissues of autologous origin....