Rational design of multistage drug delivery vehicles for pulmonary RNA interference therapy

• Published in: International journal of pharmaceutics Vol. 591; p. 119989
• Main Authors: Silva, A. Sofia, Shopsowitz, Kevin E., Correa, Santiago, Morton, Stephen W., Dreaden, Erik C., Casimiro, Teresa, Aguiar-Ricardo, Ana, Hammond, Paula T.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.2020
• Subjects: Layer-by-layer nanoparticles; Micronized systems; Pulmonary delivery; Small interfering RNAs; Supercritical carbon dioxide; Small interfering RNAs; Supercritical carbon dioxide; Layer-by-layer nanoparticles; Micronized systems; Pulmonary delivery

[Display omitted] •siRNA nanovehicles were micronized using supercritical CO2-assisted spray drying.•The siRNA integrity was preserved through the micronization process.•The ultrafine dry powders showed aerodynamic diameters of 3.5 μm and FPF above 40%•The micronized siRNA powders achieved 90% of si...