N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications

Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m 6 A methylation has attracted increasing research interest in recent years. m 6 A is c...

Full description

Saved in:
Bibliographic Details
Published inMolecular cancer Vol. 18; no. 1; pp. 1 - 8
Main Authors Hu, Bin-bin, Wang, Xiao-yan, Gu, Xu-Yu, Zou, Chen, Gao, Zhen-jun, Zhang, Heng, Fan, Yu
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 07.12.2019
BioMed Central
BMC
Subjects
Antisense RNA
Binding proteins
Cancer
Cancer research
Chromatin
Decitabine
Deoxyribonucleic acid
Development and progression
DNA
DNA methylation
DNA sequencing
Enzymes
Epigenetic inheritance
Epigenetics
Gastrointestinal system
Gastrointestinal tract
Gene expression
Genetic research
Homology
Liver cancer
Mammals
Medical prognosis
Metastasis
Methylation
Methyltransferases
MicroRNAs
Mortality
N6-methyladenosine
Phenotypes
Protein binding
Proteins
Pyrimidines
Review
RNA
RNA modification
Roles
Tumors
Writers
Online AccessGet full text
ISSN1476-4598
1476-4598
DOI10.1186/s12943-019-1099-7

Cover

Abstract Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m 6 A methylation has attracted increasing research interest in recent years. m 6 A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m 6 A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m 6 A in gastrointestinal tract cancers.
AbstractList Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m6A methylation has attracted increasing research interest in recent years. m6A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m6A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m6A in gastrointestinal tract cancers.
Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m 6 A methylation has attracted increasing research interest in recent years. m 6 A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m 6 A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m 6 A in gastrointestinal tract cancers.
Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m6A methylation has attracted increasing research interest in recent years. m6A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m6A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m6A in gastrointestinal tract cancers.Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m6A methylation has attracted increasing research interest in recent years. m6A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m6A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m6A in gastrointestinal tract cancers.
Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m.sup.6A methylation has attracted increasing research interest in recent years. m.sup.6A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m.sup.6A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m.sup.6A in gastrointestinal tract cancers.
Abstract Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m6A methylation has attracted increasing research interest in recent years. m6A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m6A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m6A in gastrointestinal tract cancers.
ArticleNumber 178
Audience Academic
Author Zou, Chen
Gu, Xu-Yu
Wang, Xiao-yan
Hu, Bin-bin
Gao, Zhen-jun
Zhang, Heng
Fan, Yu
Author_xml – sequence: 1
  givenname: Bin-bin
  surname: Hu
  fullname: Hu, Bin-bin
– sequence: 2
  givenname: Xiao-yan
  surname: Wang
  fullname: Wang, Xiao-yan
– sequence: 3
  givenname: Xu-Yu
  surname: Gu
  fullname: Gu, Xu-Yu
– sequence: 4
  givenname: Chen
  surname: Zou
  fullname: Zou, Chen
– sequence: 5
  givenname: Zhen-jun
  surname: Gao
  fullname: Gao, Zhen-jun
– sequence: 6
  givenname: Heng
  surname: Zhang
  fullname: Zhang, Heng
– sequence: 7
  givenname: Yu
  surname: Fan
  fullname: Fan, Yu
BookMark eNp1kluLFDEQhRtZcS_6A3xr8GUFe-100rn4IAyLl4VlBdHnUF1dPZOlOxmTHmH_vZmL6CxKHhJS53wkVee8OPHBU1G8ZPUVY1q-Tawxglc1MxWrjanUk-KMCSUr0Rp98tf5tDhP6b6umdJKPCtOOdOsFpqfFes7WU00rx5G6MmH5DyVl5NcvC6_3i3KKfRucAizC750vlxCmmNwfqY0Ow9jOUfAuUTwSDG9K2MYKb0pJ8IVeJemfAbfl7BejwdKel48HWBM9OKwXxTfP374dv25uv3y6eZ6cVuhkGquWqJeo-ygUYZhrwRDjTS0UJNQHEVLnRiwIdmyhueCHAha1bcGEOrGAL8obvbcPsC9XUc3QXywAZzdXYS4tBBnhyNZo7VCjsx0ahCDwS73hssuw0lr6nlmvd-z1ptuoh7J53-PR9Djincruww_rdRGG9lkwOUBEMOPTW6enVxCGkfwFDbJNrxplDBGqSx99Uh6HzYx93qn0qYVRtR_VEvIH3B-CNtJbKF2IWtljOGyzaqrf6jy6mlymLM0uHx_ZFB7A8aQUqTBopt3c8tGN1pW223w7D54NgfPboNnt89mj5y_u_N_zy8a49wS
CitedBy_id crossref_primary_10_3389_fcell_2020_587108
crossref_primary_10_3389_fimmu_2021_760747
crossref_primary_10_3389_fcell_2021_670711
crossref_primary_10_4168_aair_2024_16_2_130
crossref_primary_10_1049_syb2_12040
crossref_primary_10_1016_j_phrs_2024_107280
crossref_primary_10_1016_j_isci_2023_108779
crossref_primary_10_1007_s00335_022_09963_y
crossref_primary_10_1111_jcmm_15750
crossref_primary_10_1002_jcp_30828
crossref_primary_10_1186_s13578_020_00502_3
crossref_primary_10_1186_s40246_022_00386_z
crossref_primary_10_1016_j_jgg_2024_12_020
crossref_primary_10_1016_j_ncrna_2023_11_005
crossref_primary_10_1111_1759_7714_14741
crossref_primary_10_1186_s12943_022_01634_5
crossref_primary_10_1002_ctm2_1205
crossref_primary_10_3389_fonc_2022_824258
crossref_primary_10_3389_fimmu_2023_1128459
crossref_primary_10_1021_acssensors_4c01875
crossref_primary_10_1111_jcmm_16818
crossref_primary_10_3389_fimmu_2022_849592
crossref_primary_10_1002_jcp_30730
crossref_primary_10_1016_j_bcp_2020_114284
crossref_primary_10_1016_j_semcancer_2020_11_007
crossref_primary_10_1016_j_omtn_2021_04_002
crossref_primary_10_1152_ajpcell_00575_2022
crossref_primary_10_1038_s41420_020_00382_z
crossref_primary_10_1016_j_bcp_2024_116375
crossref_primary_10_3389_fcell_2021_711815
crossref_primary_10_3389_fonc_2022_1004212
crossref_primary_10_1002_jcla_23931
crossref_primary_10_1186_s40164_021_00234_1
crossref_primary_10_3389_fgene_2022_1087434
crossref_primary_10_1007_s10620_020_06260_z
crossref_primary_10_3389_fmed_2021_775357
crossref_primary_10_1111_jcmm_15738
crossref_primary_10_1002_cac2_12161
crossref_primary_10_1016_j_cellsig_2023_110726
crossref_primary_10_1038_s41388_022_02191_3
crossref_primary_10_4143_crt_2020_870
crossref_primary_10_3389_fonc_2024_1467850
crossref_primary_10_1016_j_bbrc_2024_150570
crossref_primary_10_1007_s11010_024_05040_x
crossref_primary_10_1186_s40246_022_00384_1
crossref_primary_10_1042_BSR20200282
crossref_primary_10_1186_s12885_022_09801_z
crossref_primary_10_1186_s12943_020_01239_w
crossref_primary_10_1155_2021_5573628
crossref_primary_10_3390_cancers12041016
crossref_primary_10_3389_fgene_2020_561566
crossref_primary_10_1186_s13045_020_00895_1
crossref_primary_10_1089_cbr_2021_0226
crossref_primary_10_3892_ijmm_2023_5289
crossref_primary_10_1186_s12916_021_02171_6
crossref_primary_10_1038_s41392_020_00450_x
crossref_primary_10_1111_jcmm_70344
crossref_primary_10_1016_j_prp_2022_154055
crossref_primary_10_1186_s13046_021_02200_5
crossref_primary_10_1111_jnc_15882
crossref_primary_10_1080_15592294_2020_1805684
crossref_primary_10_1186_s12943_020_01223_4
crossref_primary_10_1186_s12864_022_08462_3
crossref_primary_10_3389_fgene_2022_870945
crossref_primary_10_1016_j_talanta_2024_125872
crossref_primary_10_1177_0963689720946653
crossref_primary_10_1038_s41419_022_05391_7
crossref_primary_10_3389_fcell_2022_1055808
crossref_primary_10_2147_JIR_S320449
crossref_primary_10_3390_cells11203193
Cites_doi 10.1002/hep.28885
10.2147/OTT.S180954
10.1016/j.gpb.2017.03.002
10.1038/ncomms12626
10.1038/nature05384
10.1101/gad.269415.115
10.3322/caac.21262
10.1002/hep.29683
10.1128/MCB.00742-15
10.1016/j.stem.2017.11.016
10.3389/fonc.2019.00332
10.3322/caac.21338
10.1515/med-2019-0005
10.1016/j.molcel.2012.10.015
10.1038/nature24456
10.3322/caac.21220
10.1016/j.cell.2012.05.003
10.1016/j.cell.2015.05.014
10.3892/or.2017.5904
10.1007/s10620-018-5452-2
10.1186/s12943-019-1038-7
10.2147/OTT.S201052
10.1080/15384101.2017.1380125
10.1016/j.cell.2017.05.045
10.1016/j.celrep.2018.01.061
10.1038/nature16998
10.1016/j.ccr.2014.01.008
10.3233/CBM-170791
10.1371/journal.pone.0046887
10.1038/nchembio.1432
10.4161/cc.7.9.5791
10.1038/s41586-019-0916-x
10.1038/nature11112
10.1182/blood-2015-07-604512
10.2147/CMAR.S191565
10.1038/nature19342
10.1007/s13105-019-00690-8
10.1038/cr.2014.3
10.1038/nature12730
10.1016/j.cell.2017.05.003
10.1007/s13277-016-5215-7
10.1016/j.sbi.2015.09.007
10.1002/cam4.2360
10.1073/pnas.71.10.3971
10.1002/jcp.28994
10.14701/ahbps.2018.22.4.305
10.1093/nar/gkx1030
10.2174/156800961506150805153230
10.1093/nar/gkx515
10.3322/caac.21492
10.1016/j.bpg.2005.10.001
10.1016/j.celrep.2014.05.048
10.1074/jbc.M116.749689
10.1016/j.molcel.2018.06.001
10.1038/nchembio.687
10.1038/s41419-019-1585-2
10.18632/oncotarget.23554
10.1016/j.molcel.2016.05.041
10.1002/jcb.26685
10.1038/nature24678
10.1101/gad.301036.117
10.3390/ijms20061323
10.1080/15476286.2016.1201628
ContentType Journal Article
Copyright COPYRIGHT 2019 BioMed Central Ltd.
2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s). 2019
Copyright_xml – notice: COPYRIGHT 2019 BioMed Central Ltd.
– notice: 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s). 2019
DBID AAYXX
CITATION
3V.
7TO
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
H94
K9.
M0S
M1P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1186/s12943-019-1099-7
DatabaseName CrossRef
ProQuest Central (Corporate)
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
Oncogenes and Growth Factors Abstracts
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database
CrossRef

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1476-4598
EndPage 8
ExternalDocumentID oai_doaj_org_article_9887c3c19b7f4f9cb10436b2e6e88ed3
PMC6898962
A607999365
10_1186_s12943_019_1099_7
GrantInformation_xml – fundername: ;
  grantid: BE2015666
– fundername: ;
  grantid: BRA2016140
– fundername: ;
  grantid: S201522
– fundername: ;
  grantid: BK20171304
– fundername: ;
  grantid: CXTDC2016006
– fundername: ;
  grantid: WSW-205
GroupedDBID ---
0R~
123
29M
2WC
53G
5VS
7X7
88E
8FI
8FJ
AAFWJ
AAJSJ
AASML
AAYXX
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACIWK
ACMJI
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C6C
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EAD
EAP
EAS
EBD
EBLON
EBS
EJD
EMB
EMK
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HH5
HMCUK
HYE
IAO
IHR
INH
INR
ITC
KQ8
M1P
M48
M~E
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PZZ
RBZ
RNS
ROL
RPM
RSV
SBL
SOJ
SV3
TR2
TUS
UKHRP
W2D
WOQ
WOW
XSB
PMFND
3V.
7TO
7XB
8FK
AZQEC
DWQXO
H94
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c467t-5eed8c6ba2791cd741c8cef5a0e473c45eb4fc2e65123cef6fea57d59aca029a3
IEDL.DBID 7X7
ISSN 1476-4598
IngestDate Wed Aug 27 01:26:55 EDT 2025
Thu Aug 21 18:43:05 EDT 2025
Mon Jul 21 09:33:32 EDT 2025
Fri Jul 25 20:05:34 EDT 2025
Tue Jun 17 21:50:52 EDT 2025
Tue Jun 10 20:36:48 EDT 2025
Thu Apr 24 22:58:56 EDT 2025
Tue Jul 01 01:01:17 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c467t-5eed8c6ba2791cd741c8cef5a0e473c45eb4fc2e65123cef6fea57d59aca029a3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
OpenAccessLink https://www.proquest.com/docview/2328954940?pq-origsite=%requestingapplication%
PMID 31810483
PQID 2328954940
PQPubID 42702
PageCount 8
ParticipantIDs doaj_primary_oai_doaj_org_article_9887c3c19b7f4f9cb10436b2e6e88ed3
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6898962
proquest_miscellaneous_2322749977
proquest_journals_2328954940
gale_infotracmisc_A607999365
gale_infotracacademiconefile_A607999365
crossref_citationtrail_10_1186_s12943_019_1099_7
crossref_primary_10_1186_s12943_019_1099_7
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2019-12-07
PublicationDateYYYYMMDD 2019-12-07
PublicationDate_xml – month: 12
  year: 2019
  text: 2019-12-07
  day: 07
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Molecular cancer
PublicationYear 2019
Publisher BioMed Central Ltd
BioMed Central
BMC
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
– name: BMC
References X Cheng (1099_CR46) 2019; 12
DP Patil (1099_CR26) 2016; 537
XL Ping (1099_CR20) 2014; 24
M Cui (1099_CR45) 2016; 37
J Chen (1099_CR41) 2017; 16
D Han (1099_CR63) 2019; 566
S Ke (1099_CR14) 2015; 29
RK Ng (1099_CR1) 2008; 7
X Wang (1099_CR30) 2014; 505
PJ Batista (1099_CR9) 2017; 15
S Adhikari (1099_CR12) 2016; 13
L Ricci-Vitiani (1099_CR53) 2007; 445
L Zhu (1099_CR61) 2019; 10
Y Li (1099_CR3) 2015; 15
R Desrosiers (1099_CR16) 1974; 71
D Dominissini (1099_CR17) 2012; 485
S Schwartz (1099_CR21) 2014; 8
G Zheng (1099_CR28) 2013; 9
IO Torres (1099_CR29) 2015; 35
Tong Liu (1099_CR36) 2019; 235
D Dominissini (1099_CR5) 2016; 530
H Weng (1099_CR24) 2018; 22
R Yu (1099_CR66) 2019; 20
G Jia (1099_CR27) 2011; 7
X Wang (1099_CR31) 2015; 161
Y Bai (1099_CR40) 2019; 9
M Safra (1099_CR6) 2017; 551
B Genenncher (1099_CR13) 2018; 22
S Lin (1099_CR34) 2019; 14
BB Zhao (1099_CR65) 2018; 119
KE Pendleton (1099_CR25) 2017; 169
Y Nishizawa (1099_CR39) 2017; 9
F Bray (1099_CR50) 2018; 68
K Taketo (1099_CR62) 2018; 52
IA Roundtree (1099_CR11) 2017; 169
I Barbieri (1099_CR23) 2017; 552
P Wei (1099_CR55) 2012; 7
Y Li (1099_CR58) 2019; 64
R Deng (1099_CR38) 2019; 12
B Chen (1099_CR64) 2012; 134
P Wang (1099_CR22) 2016; 63
Jun Zhang (1099_CR49) 2019; 75
J Liu (1099_CR19) 2014; 10
C You (1099_CR7) 2017; 45
W Chen (1099_CR48) 2016; 66
R Siegel (1099_CR51) 2014; 64
S Lin (1099_CR8) 2018; 71
H Du (1099_CR43) 2016; 7
BJ Wouters (1099_CR2) 2016; 127
D Xu (1099_CR59) 2017; 38
Z Yang (1099_CR33) 2017; 292
P Boccaletto (1099_CR10) 2018; 46
Y Zhou (1099_CR56) 2019; 11
AB Lowenfels (1099_CR54) 2006; 20
Cheng Zhang (1099_CR35) 2019; 8
J Xing (1099_CR4) 2015; 35
M Chen (1099_CR44) 2018; 67
LA Torre (1099_CR47) 2015; 65
Verline Justilien (1099_CR52) 2014; 25
S Ke (1099_CR15) 2017; 31
X Zhao (1099_CR57) 2018; 21
SH Cho (1099_CR60) 2018; 22
JZ Ma (1099_CR32) 2017; 65
T Li (1099_CR37) 2019; 18
X Tang (1099_CR42) 2019; 17
KD Meyer (1099_CR18) 2012; 149
References_xml – volume: 65
  start-page: 529
  issue: 2
  year: 2017
  ident: 1099_CR32
  publication-title: Hepatology.
  doi: 10.1002/hep.28885
– volume: 12
  start-page: 3421
  year: 2019
  ident: 1099_CR46
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S180954
– volume: 15
  start-page: 154
  issue: 3
  year: 2017
  ident: 1099_CR9
  publication-title: Genomics Proteomics Bioinformatics
  doi: 10.1016/j.gpb.2017.03.002
– volume: 7
  start-page: 12626
  year: 2016
  ident: 1099_CR43
  publication-title: Nat Commun
  doi: 10.1038/ncomms12626
– volume: 445
  start-page: 111
  issue: 7123
  year: 2007
  ident: 1099_CR53
  publication-title: Nature.
  doi: 10.1038/nature05384
– volume: 29
  start-page: 2037
  issue: 19
  year: 2015
  ident: 1099_CR14
  publication-title: Genes Dev
  doi: 10.1101/gad.269415.115
– volume: 65
  start-page: 87
  issue: 2
  year: 2015
  ident: 1099_CR47
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21262
– volume: 67
  start-page: 2254
  issue: 6
  year: 2018
  ident: 1099_CR44
  publication-title: Hepatology.
  doi: 10.1002/hep.29683
– volume: 35
  start-page: 4043
  issue: 23
  year: 2015
  ident: 1099_CR4
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00742-15
– volume: 22
  start-page: 191
  issue: 2
  year: 2018
  ident: 1099_CR24
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2017.11.016
– volume: 9
  start-page: 332
  year: 2019
  ident: 1099_CR40
  publication-title: Front Oncol
  doi: 10.3389/fonc.2019.00332
– volume: 66
  start-page: 115
  issue: 2
  year: 2016
  ident: 1099_CR48
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21338
– volume: 134
  start-page: 17963e17971
  issue: 43
  year: 2012
  ident: 1099_CR64
  publication-title: J Am Chem Soc
– volume: 14
  start-page: 25
  year: 2019
  ident: 1099_CR34
  publication-title: Open Med (Wars)
  doi: 10.1515/med-2019-0005
– volume: 9
  start-page: 18
  issue: 1
  year: 2013
  ident: 1099_CR28
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.10.015
– volume: 551
  start-page: 251
  issue: 7679
  year: 2017
  ident: 1099_CR6
  publication-title: Nature
  doi: 10.1038/nature24456
– volume: 64
  start-page: 104
  issue: 2
  year: 2014
  ident: 1099_CR51
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21220
– volume: 149
  start-page: 1635
  issue: 7
  year: 2012
  ident: 1099_CR18
  publication-title: Cell.
  doi: 10.1016/j.cell.2012.05.003
– volume: 161
  start-page: 1388
  issue: 6
  year: 2015
  ident: 1099_CR31
  publication-title: Cell.
  doi: 10.1016/j.cell.2015.05.014
– volume: 38
  start-page: 2285
  issue: 4
  year: 2017
  ident: 1099_CR59
  publication-title: Oncol Rep
  doi: 10.3892/or.2017.5904
– volume: 64
  start-page: 1503
  issue: 6
  year: 2019
  ident: 1099_CR58
  publication-title: Dig Dis Sci
  doi: 10.1007/s10620-018-5452-2
– volume: 18
  start-page: 112
  issue: 1
  year: 2019
  ident: 1099_CR37
  publication-title: Mol Cancer
  doi: 10.1186/s12943-019-1038-7
– volume: 12
  start-page: 4391
  year: 2019
  ident: 1099_CR38
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S201052
– volume: 16
  start-page: 2259
  issue: 23
  year: 2017
  ident: 1099_CR41
  publication-title: Cell Cycle
  doi: 10.1080/15384101.2017.1380125
– volume: 169
  start-page: 1187
  issue: 7
  year: 2017
  ident: 1099_CR11
  publication-title: Cell
  doi: 10.1016/j.cell.2017.05.045
– volume: 22
  start-page: 1861
  issue: 7
  year: 2018
  ident: 1099_CR13
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2018.01.061
– volume: 530
  start-page: 441
  issue: 7591
  year: 2016
  ident: 1099_CR5
  publication-title: Nature
  doi: 10.1038/nature16998
– volume: 25
  start-page: 139
  issue: 2
  year: 2014
  ident: 1099_CR52
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2014.01.008
– volume: 21
  start-page: 859
  issue: 4
  year: 2018
  ident: 1099_CR57
  publication-title: Cancer Biomark
  doi: 10.3233/CBM-170791
– volume: 7
  start-page: e46887
  issue: 10
  year: 2012
  ident: 1099_CR55
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0046887
– volume: 10
  start-page: 93
  issue: 2
  year: 2014
  ident: 1099_CR19
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.1432
– volume: 7
  start-page: 1173
  issue: 9
  year: 2008
  ident: 1099_CR1
  publication-title: Cell Cycle
  doi: 10.4161/cc.7.9.5791
– volume: 17
  start-page: 2473
  issue: 2
  year: 2019
  ident: 1099_CR42
  publication-title: Oncol Lett
– volume: 566
  start-page: 270
  issue: 7743
  year: 2019
  ident: 1099_CR63
  publication-title: Nature.
  doi: 10.1038/s41586-019-0916-x
– volume: 52
  start-page: 621
  issue: 2
  year: 2018
  ident: 1099_CR62
  publication-title: Int J Oncol
– volume: 485
  start-page: 201
  issue: 7397
  year: 2012
  ident: 1099_CR17
  publication-title: Nature
  doi: 10.1038/nature11112
– volume: 127
  start-page: 42
  issue: 1
  year: 2016
  ident: 1099_CR2
  publication-title: Blood
  doi: 10.1182/blood-2015-07-604512
– volume: 11
  start-page: 3921
  year: 2019
  ident: 1099_CR56
  publication-title: Cancer Manag Res
  doi: 10.2147/CMAR.S191565
– volume: 537
  start-page: 369
  issue: 7620
  year: 2016
  ident: 1099_CR26
  publication-title: Nature
  doi: 10.1038/nature19342
– volume: 75
  start-page: 379
  issue: 3
  year: 2019
  ident: 1099_CR49
  publication-title: Journal of Physiology and Biochemistry
  doi: 10.1007/s13105-019-00690-8
– volume: 24
  start-page: 177
  issue: 2
  year: 2014
  ident: 1099_CR20
  publication-title: Cell Res
  doi: 10.1038/cr.2014.3
– volume: 505
  start-page: 117
  year: 2014
  ident: 1099_CR30
  publication-title: Nature
  doi: 10.1038/nature12730
– volume: 169
  start-page: 824
  issue: 5
  year: 2017
  ident: 1099_CR25
  publication-title: Cell.
  doi: 10.1016/j.cell.2017.05.003
– volume: 37
  start-page: 13521
  issue: 10
  year: 2016
  ident: 1099_CR45
  publication-title: Tumour Biol
  doi: 10.1007/s13277-016-5215-7
– volume: 35
  start-page: 68
  year: 2015
  ident: 1099_CR29
  publication-title: Curr Opin Struct Biol
  doi: 10.1016/j.sbi.2015.09.007
– volume: 8
  start-page: 4766
  issue: 10
  year: 2019
  ident: 1099_CR35
  publication-title: Cancer Medicine
  doi: 10.1002/cam4.2360
– volume: 71
  start-page: 3971
  issue: 10
  year: 1974
  ident: 1099_CR16
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.71.10.3971
– volume: 235
  start-page: 548
  issue: 1
  year: 2019
  ident: 1099_CR36
  publication-title: Journal of Cellular Physiology
  doi: 10.1002/jcp.28994
– volume: 22
  start-page: 305
  issue: 4
  year: 2018
  ident: 1099_CR60
  publication-title: Ann Hepatobiliary Pancreat Surg
  doi: 10.14701/ahbps.2018.22.4.305
– volume: 46
  start-page: D303
  issue: D1
  year: 2018
  ident: 1099_CR10
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkx1030
– volume: 15
  start-page: 493
  issue: 6
  year: 2015
  ident: 1099_CR3
  publication-title: Curr Cancer Drug Targets
  doi: 10.2174/156800961506150805153230
– volume: 45
  start-page: 9059
  issue: 15
  year: 2017
  ident: 1099_CR7
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkx515
– volume: 68
  start-page: 394
  issue: 6
  year: 2018
  ident: 1099_CR50
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21492
– volume: 20
  start-page: 197
  issue: 2
  year: 2006
  ident: 1099_CR54
  publication-title: Best Pract Res Clin Gastroenterol
  doi: 10.1016/j.bpg.2005.10.001
– volume: 8
  start-page: 284
  issue: 1
  year: 2014
  ident: 1099_CR21
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2014.05.048
– volume: 292
  start-page: 3614
  issue: 9
  year: 2017
  ident: 1099_CR33
  publication-title: Protein J Biol Chem
  doi: 10.1074/jbc.M116.749689
– volume: 71
  start-page: 244
  issue: 2
  year: 2018
  ident: 1099_CR8
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2018.06.001
– volume: 7
  start-page: 885
  issue: 12
  year: 2011
  ident: 1099_CR27
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.687
– volume: 10
  start-page: 383
  issue: 6
  year: 2019
  ident: 1099_CR61
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-1585-2
– volume: 9
  start-page: 7476
  issue: 7
  year: 2017
  ident: 1099_CR39
  publication-title: Oncotarget.
  doi: 10.18632/oncotarget.23554
– volume: 63
  start-page: 306
  issue: 2
  year: 2016
  ident: 1099_CR22
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2016.05.041
– volume: 119
  start-page: 5382
  issue: 7
  year: 2018
  ident: 1099_CR65
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.26685
– volume: 552
  start-page: 126
  issue: 7683
  year: 2017
  ident: 1099_CR23
  publication-title: Nature
  doi: 10.1038/nature24678
– volume: 31
  start-page: 990
  issue: 10
  year: 2017
  ident: 1099_CR15
  publication-title: Genes Dev
  doi: 10.1101/gad.301036.117
– volume: 20
  start-page: E1323
  issue: 6
  year: 2019
  ident: 1099_CR66
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20061323
– volume: 13
  start-page: 756
  issue: 9
  year: 2016
  ident: 1099_CR12
  publication-title: RNA Biol
  doi: 10.1080/15476286.2016.1201628
SSID ssj0017874
Score 2.5314553
SecondaryResourceType review_article
Snippet Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in...
Abstract Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases,...
SourceID doaj
pubmedcentral
proquest
gale
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage 1
SubjectTerms Antisense RNA
Binding proteins
Cancer
Cancer research
Chromatin
Decitabine
Deoxyribonucleic acid
Development and progression
DNA
DNA methylation
DNA sequencing
Enzymes
Epigenetic inheritance
Epigenetics
Gastrointestinal system
Gastrointestinal tract
Gene expression
Genetic research
Homology
Liver cancer
Mammals
Medical prognosis
Metastasis
Methylation
Methyltransferases
MicroRNAs
Mortality
N6-methyladenosine
Phenotypes
Protein binding
Proteins
Pyrimidines
Review
RNA
RNA modification
Roles
Tumors
Writers
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYl0NJLadOWbpoGBQJ9UBE_ZD1y24SEUMgeSgO5CUmW24WsN6ydQ_59Z2Ttsm4hvfRm9MDWPDQjz-gbQo5K5QIcZRvGwZdgvPScuTyUrJEKrLXLGu_xP-TVTFxe82831c1WqS_MCRvggQfCHWvQAl_6XDvZ8EZ7lyNouiuCCEqFOuJ8gs1bH6ZS_ADEkKcYZq7EcQdWjWPekGYYCWJyZIUiWP_fW_KfaZJbdufiJXmRHEY6HT70FXkS2l3ydCgh-bBLnl2l4PhrcjcTDAtCP9zaGiHAoZF-WojpZ_p9NqWLZY1ZQZERdN7Sn7brV0tEiwAlxzf0eF-KepSCVXdCMe2w-0oXAa8Gz7sFPNu2ptsB7zfk-uL8x9klSwUVmIf9sGcVGETlhbOF1LmvwZnwyoemslngEthUBccbD6QFL6CEDtEEW8m60tbbrNC2fEt22mUb3hFa8JJnteY-zxGORqCfCZ5NCE47zUU2IdmawMYntHEsenFr4qlDCTPwxABPMAqujZyQL5spdwPUxmODT5Frm4GIkh0bQHZMkh3zL9mZkI_Ic4O6jES26UoCLBFRscxUZBIWVopqQvZHI0EH_bh7LTUm7QGdAV9VYRCVAzEON904E_Pa2rC8j2MKCYdOCQuSI2kbrWzc085_RRxwgaU_RbH3P0jxnjwvonpgLvI-2elX9-EDuFu9O4ia9RvT0iez
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3daxQxEA-1ovgiWhVPa4kg-IGp-5FNNoUip1iKcPcgHvQtJNlsPbjbrbtb8P57Z3J7Z7eWvi35IExmJjPZmfyGkDdpbj1cZUvGwZdgPHWc2dinrJQ5WGsblc7hf8jJVJzO-Pez7GyHbMpb9RvY3ni1w3pSs2Zx-Of36jMo_HFQ-Fx8asFmccwKUgzjPEzeIXfBMEms5DDh_4IKIJu8D2zeOG1gmgKC___n9PXcySvG6OQRedh7kXS8ZvtjsuOrPXJvXVdytUfuT_qI-RNyMRUMq0SvFqZAXHBopO-WYvye_piO6bIuMFUocIfOK3pu2q6pEUICNB9X6PARFXUoGk17RDEXsf1Ilx7fC8_bJXybqqBXo-BPyezk28-vp6yvssAcHJIdy8BK5k5Yk0gVuwI8DJc7X2Ym8lwC7zJveekSL8A1SKFDlN5kssiUcSZKlEmfkd2qrvxzQhOe8qhQ3MUxYtQIdD7B3fHeKqu4iEYk2mywdj0EOVbCWOhwFcmFXvNEA08wNK60HJEP2ykXa_yN2wZ_Qa5tByJ0dmiom3Pda6JWcKy61MXKypKXytkYUfgtEOjz3BfpiLxFnmsUOdxk079TABIRKkuPRSSBsFRkI7I_GAmK6YbdG6nRG7nW4MDmGFnlsBmvt904E5PdKl9fhjGJhJuoBILkQNoGlA17qvmvAA4usB6oSF7cvvhL8iAJgo-px_tkt2su_Svwrjp7EHTmL6cFIfU
  priority: 102
  providerName: Scholars Portal
Title N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
URI https://www.proquest.com/docview/2328954940
https://www.proquest.com/docview/2322749977
https://pubmed.ncbi.nlm.nih.gov/PMC6898962
https://doaj.org/article/9887c3c19b7f4f9cb10436b2e6e88ed3
Volume 18
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELdgE4gXBANEYFRGQuJDWMuH4w9eUIY2TZVaocGkvlmx44xKa1Ka7mH_PXepWxaQ9tJUsaPocuf78J1_R8i7TFkPoWzNOPgSjGeOM5v4jNVSgbW2ce0c7kNOpuLsgo9n-SxsuHWhrHKrE3tFXbUO98iPwPIrTEnx-OvyN8OuUZhdDS007pN9hC7D4EvOdgFXAsLIQyYzUeKoA9vGsXpIM8wHMTmwRT1k__-K-d9iyVvW5_QJeRzcRlps-PyU3PPNAXmwaSR5c0AeTkKK_BlZTgXDttA3V2WFQOBwk35YiOIjPZ8WdNFWWBvUs4POG3pZdutVi5gRsNTxDWs8NUUdysKq-0Kx-LD7TBceDwjPuwX8L5uK3k57PycXpyc_v52x0FaBOdCKa5aDWVRO2DKVOnEVuBROOV_nZey5BGbl3vLapV6AL5DBgKh9mcsq16Ur41SX2Quy17SNf0loyjMeV5q7JEFQGoHeJvg33lttNRdxROLtBzYuYI5j64sr08ceSpgNTwzwBHPh2siIfNo9stwAbtw1-Ri5tpuIWNn9jXZ1acLSMxr0qMtcoq2sea2dTRB23wKBXilfZRF5jzw3uKLxI5fhYAKQiNhYphCxBMIykUfkcDATVqIbDm-lxgRN0Jm_chuRt7thfBKr2xrfXvdzUgmhpwSC5EDaBpQNR5r5rx4NXGADUJG-uvvlr8mjtBd8rDU-JHvr1bV_A-7U2o76NTMi-0Ux_jGG6_HJ9Pv5qN-cgN8JV38AG1Yj7g
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NTny8IBggCgOMBAImrOXDsRMkhDrY1LG1QtMm7c3EjjMqrUlpOqH-U_yN3KVpWUDa296q2Glyvo_fOXe-A3gVxsbhVjbnAn0JLkIruPFdyHMVI1obL7eWvkMOhrJ_Ir6eRqdr8Ht5FobSKpc2sTbUWWnpG_k2In9MISnhfZr85NQ1iqKryxYaC7E4cPNfuGWrPu5_Qf6-DoK93ePPfd50FeAWjcKMR4gKsZUmDVTi2wwR1cbW5VHqOaHwXSNnRG4DJxEKQxyQuUsjlUVJalMvSNIQ__cGrIsQXYUOrO_sDr8dreIWKP6iiZ36sdyuEE0F5SslnCJQXLXQr24S8D8U_JueeQnv9u7B3cZRZb2FZN2HNVdswM1F68r5BtwaNEH5BzAZSk6NqOfnaUalx_EiezuWvXfsaNhj4zKjbKRaANioYGdpNZuWVKUCjQs9YUbntJgl6ZtWHxilO1bv2djRkeRRNcbfaZGxy4H2h3ByLUv-CDpFWbjHwAIRCi9LhPV9KoMjyb9Fj8o5k5hESK8L3nKBtW2qnFOzjXNd73ZiqRc80cgTir4nWnVha3XLZFHi46rJO8S11USqzl1fKKdnulF2naDltqH1E6NykSfW-FTo3yCBLo5dFnbhDfFckw2hRU6boxBIIlXj0j3pKSQslFEXNlszUfdte3gpNbqxPZX-qyldeLkapjspn65w5UU9J1C42VVIkGpJW4uy9kgx-lHXH5fUclQGT65--Au43T8eHOrD_eHBU7gT1EpAmc6b0JlNL9wzdOZm5nmjQQy-X7fS_gHo8V-q
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=N6-methyladenosine+%28m6A%29+RNA+modification+in+gastrointestinal+tract+cancers%3A+roles%2C+mechanisms%2C+and+applications&rft.jtitle=Molecular+cancer&rft.au=Bin-bin%2C+Hu&rft.au=Xiao-yan%2C+Wang&rft.au=Xu-Yu%2C+Gu&rft.au=Zou%2C+Chen&rft.date=2019-12-07&rft.pub=BioMed+Central&rft.eissn=1476-4598&rft.volume=18&rft.spage=1&rft_id=info:doi/10.1186%2Fs12943-019-1099-7
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1476-4598&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1476-4598&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1476-4598&client=summon