How to Determine the Role of the Microbiome in Drug Disposition

• Published in: Drug metabolism and disposition Vol. 46; no. 11; pp. 1588 - 1595
• Main Authors: Bisanz, Jordan E., Spanogiannopoulos, Peter, Pieper, Lindsey M., Bustion, Annamarie E., Turnbaugh, Peter J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2018; American Society for Pharmacology and Experimental Therapeutics, Inc; The American Society for Pharmacology and Experimental Therapeutics
• Subjects: Animals; Drug development; Drug Discovery - methods; Drug metabolism; Environmental factors; Environmental impact; Excretion; Gastrointestinal Microbiome - physiology; Humans; In vivo methods and tests; Inactivation, Metabolic - physiology; Medicine; Metabolism; Microbiomes; Pharmaceutical Preparations - metabolism; Pharmacology; Precision medicine; Special Section – New Models in Drug Metabolism and Transport; BBB; PXR

With a paradigm shift occurring in health care toward personalized and precision medicine, understanding the numerous environmental factors that impact drug disposition is of paramount importance. The highly diverse and variant nature of the human microbiome is now recognized as a factor driving int...