How to Determine the Role of the Microbiome in Drug Disposition
With a paradigm shift occurring in health care toward personalized and precision medicine, understanding the numerous environmental factors that impact drug disposition is of paramount importance. The highly diverse and variant nature of the human microbiome is now recognized as a factor driving int...
Saved in:
| Published in | Drug metabolism and disposition Vol. 46; no. 11; pp. 1588 - 1595 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.11.2018
American Society for Pharmacology and Experimental Therapeutics, Inc The American Society for Pharmacology and Experimental Therapeutics |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | With a paradigm shift occurring in health care toward personalized and precision medicine, understanding the numerous environmental factors that impact drug disposition is of paramount importance. The highly diverse and variant nature of the human microbiome is now recognized as a factor driving interindividual variation in therapeutic outcomes. The purpose of this review is to provide a practical guide on methodology that can be applied to study the effects of microbes on the absorption, distribution, metabolism, and excretion of drugs. We also highlight recent examples of how these methods have been successfully applied to help build the basis for researching the intersection of the microbiome and pharmacology. Although in vitro and in vivo preclinical models are highlighted, these methods are also relevant in late-phase drug development or even as a part of routine after-market surveillance. These approaches will aid in filling major knowledge gaps for both current and upcoming therapeutics with the long-term goal of achieving a new type of knowledge-based medicine that integrates data on the host and the microbiome. |
|---|---|
| AbstractList | With a paradigm shift occurring in health care toward personalized and precision medicine, understanding the numerous environmental factors that impact drug disposition is of paramount importance. The highly diverse and variant nature of the human microbiome is now recognized as a factor driving interindividual variation in therapeutic outcomes. The purpose of this review is to provide a practical guide on methodology that can be applied to study the effects of microbes on the absorption, distribution, metabolism, and excretion of drugs. We also highlight recent examples of how these methods have been successfully applied to help build the basis for researching the intersection of the microbiome and pharmacology. Although in vitro and in vivo preclinical models are highlighted, these methods are also relevant in late-phase drug development or even as a part of routine after-market surveillance. These approaches will aid in filling major knowledge gaps for both current and upcoming therapeutics with the long-term goal of achieving a new type of knowledge-based medicine that integrates data on the host and the microbiome. With a paradigm shift occurring in health care toward personalized and precision medicine, understanding the numerous environmental factors that impact drug disposition is of paramount importance. The highly diverse and variant nature of the human microbiome is now recognized as a factor driving interindividual variation in therapeutic outcomes. The purpose of this review is to provide a practical guide on methodology that can be applied to study the effects of microbes on the absorption, distribution, metabolism, and excretion of drugs. We also highlight recent examples of how these methods have been successfully applied to help build the basis for researching the intersection of the microbiome and pharmacology. Although in vitro and in vivo preclinical models are highlighted, these methods are also relevant in late-phase drug development or even as a part of routine after-market surveillance. These approaches will aid in filling major knowledge gaps for both current and upcoming therapeutics with the long-term goal of achieving a new type of knowledge-based medicine that integrates data on the host and the microbiome.With a paradigm shift occurring in health care toward personalized and precision medicine, understanding the numerous environmental factors that impact drug disposition is of paramount importance. The highly diverse and variant nature of the human microbiome is now recognized as a factor driving interindividual variation in therapeutic outcomes. The purpose of this review is to provide a practical guide on methodology that can be applied to study the effects of microbes on the absorption, distribution, metabolism, and excretion of drugs. We also highlight recent examples of how these methods have been successfully applied to help build the basis for researching the intersection of the microbiome and pharmacology. Although in vitro and in vivo preclinical models are highlighted, these methods are also relevant in late-phase drug development or even as a part of routine after-market surveillance. These approaches will aid in filling major knowledge gaps for both current and upcoming therapeutics with the long-term goal of achieving a new type of knowledge-based medicine that integrates data on the host and the microbiome. |
| Author | Bisanz, Jordan E. Bustion, Annamarie E. Pieper, Lindsey M. Spanogiannopoulos, Peter Turnbaugh, Peter J. |
| Author_xml | – sequence: 1 givenname: Jordan E. surname: Bisanz fullname: Bisanz, Jordan E. – sequence: 2 givenname: Peter surname: Spanogiannopoulos fullname: Spanogiannopoulos, Peter – sequence: 3 givenname: Lindsey M. surname: Pieper fullname: Pieper, Lindsey M. – sequence: 4 givenname: Annamarie E. surname: Bustion fullname: Bustion, Annamarie E. – sequence: 5 givenname: Peter J. orcidid: 0000-0002-0888-2875 surname: Turnbaugh fullname: Turnbaugh, Peter J. email: Peter.Turnbaugh@ucsf.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30111623$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1Uc9LHTEYDEWpT-vVoyz00ss-v_zaH5cW8bVasBRKC72FvORbjewmr0nW0v--0afSCp6-gcwMk5l9suODR0KOKCwpZeLETraAbgkdF8BekQWVjNYA_c8dsigH6l7KZo_sp3QDQIXg_Wuyx4FS2jC-IB8uwu8qh2qFGePkPFb5GqtvYcQqDPf4izMxrF2YsHK-WsX5qlq5tAnJZRf8G7I76DHh4cM9ID8-ffx-dlFffj3_fHZ6WRvRtLmWyFqhubBghDAoALjVcmBNW2ILyy1oYKKlKAdr225YG2t6pMZQqq2Qmh-Q91vfzbye0Br0OepRbaKbdPyjgnbq_xfvrtVVuFUt57yRTTF492AQw68ZU1aTSwbHUXsMc1IMup710LeyUN8-o96EOfryPcVoIyTrO9YW1vG_iZ6iPHZbCGJLKP2lFHFQxmV9V1oJ6EZFQd1NqMqEBXRqO2GRLZ_JHp1fFHRbAZb-bx1GlYxDb9C6iCYrG9xL0r_D9q-Y |
| CitedBy_id | crossref_primary_10_1002_art_41622 crossref_primary_10_1093_ofid_ofad195 crossref_primary_10_1002_phar_2428 crossref_primary_10_3390_microorganisms7120610 crossref_primary_10_1038_s41584_020_0395_3 crossref_primary_10_1152_ajpgi_00026_2020 crossref_primary_10_1080_17425255_2018_1530216 crossref_primary_10_1016_j_jand_2022_10_004 crossref_primary_10_3389_fphar_2023_1111115 crossref_primary_10_1016_j_gtc_2019_05_001 crossref_primary_10_1073_pnas_1902596116 crossref_primary_10_1002_cpt_1870 crossref_primary_10_1016_j_neuro_2019_08_005 crossref_primary_10_1016_j_tim_2022_01_014 crossref_primary_10_1007_s00442_021_04962_3 crossref_primary_10_1016_j_fm_2023_104448 crossref_primary_10_1002_cpt_1677 crossref_primary_10_3389_fphar_2020_00390 crossref_primary_10_1002_admt_202400434 crossref_primary_10_1016_j_isci_2024_110122 crossref_primary_10_1080_17425247_2023_2233900 crossref_primary_10_1016_j_apsb_2020_09_013 crossref_primary_10_1073_pnas_1920483117 crossref_primary_10_3390_pharmaceutics13020272 crossref_primary_10_3389_fphys_2019_01343 crossref_primary_10_1016_j_copbio_2022_102801 crossref_primary_10_3390_foods13132135 crossref_primary_10_1080_00498254_2022_2124389 crossref_primary_10_1124_dmd_118_084293 crossref_primary_10_3389_fmicb_2023_1274925 crossref_primary_10_1038_s41564_022_01226_5 crossref_primary_10_1016_j_toxrep_2020_07_010 crossref_primary_10_1002_jmv_28691 |
| Cites_doi | 10.1124/dmd.115.064477 10.1128/mSystems.00195-17 10.1073/pnas.77.8.4961 10.1007/978-1-60327-853-9_21 10.1016/0006-2952(80)90304-4 10.1214/aoms/1177731363 10.1126/science.1235872 10.1073/pnas.0904489106 10.1084/jem.20130301 10.1159/000138437 10.1126/science.6836275 10.1128/mBio.00271-10 10.3109/00498258409151481 10.1254/jjp.59.1 10.2174/187569210792246326 10.1126/science.291.5505.881 10.1128/aem.63.7.2832-2835.1997 10.1124/dmd.106.012831 10.1038/nrd1470 10.1124/dmd.117.077222 10.1038/clpt.2012.96 10.1016/j.immuni.2014.06.014 10.1111/j.2042-7158.1997.tb06790.x 10.1016/S0090-9556(25)06545-6 10.1016/S0022-3565(25)31588-0 10.1126/scitranslmed.3009759 10.1038/s41522-017-0034-1 10.1186/s40168-018-0439-y 10.1124/dmd.32.3.281 10.1016/j.bbamem.2017.10.010 10.1177/0748730414544740 10.1038/nbt.3353 10.1016/j.bbi.2016.02.020 10.1073/pnas.85.12.4486 10.1039/c3ib40126j 10.1128/AAC.29.1.44 10.1136/gutjnl-2011-301104 10.3109/00498259109039513 10.1016/S0022-3565(25)29238-2 10.1093/bioinformatics/btt703 10.1007/s11095-016-1998-x 10.1073/pnas.1102938108 10.1016/j.cell.2017.03.040 10.1097/00008571-199702000-00005 10.1021/acsinfecdis.7b00139 10.1126/scitranslmed.aal4069 10.1124/dmd.111.040188 10.1073/pnas.1610856113 10.1073/pnas.97.7.3473 10.3109/00498258709043976 10.1038/nature08821 10.1124/dmd.115.063545 10.1093/bioinformatics/btv382 10.1038/nature15817 10.1016/j.tips.2010.03.003 10.1128/JB.01982-07 10.1080/19490976.2015.1127463 10.1093/nar/gkx977 10.1038/clpt.2011.287 10.1038/clpt.2008.1 10.1186/s40168-017-0306-2 10.1016/0006-2952(72)90125-6 10.1038/nrmicro.2016.17 10.1016/S0169-409X(00)00128-9 10.4014/jmb.1112.12028 10.1016/S0140-6736(00)97447-6 10.1002/(SICI)1099-0801(199906)13:4<262::AID-BMC832>3.0.CO;2-2 10.4161/gmic.23867 10.1016/S0378-5173(01)00794-3 10.7554/eLife.33953 10.1016/S0378-5173(02)00018-2 10.1124/dmd.114.058354 10.1002/hep.29327 10.4049/jimmunol.1402481 10.1038/srep12689 10.1124/dmd.111.044362 10.1073/pnas.1324049111 10.1038/nature25979 10.1126/science.1191175 10.1038/ncomms11535 10.1124/dmd.109.027565 10.1177/2211068211428190 10.1038/ismej.2011.212 10.1056/NEJM198110013051403 10.1016/j.cell.2017.03.046 10.1016/S0022-3565(24)37858-9 10.1038/s41575-018-0011-z 10.1086/516204 10.3109/00498257409052100 10.1016/j.cell.2012.10.052 10.1016/j.mib.2013.09.008 10.1038/nmicrobiol.2016.203 10.1111/j.2042-7158.1973.tb10043.x 10.1002/jps.2600840425 10.1023/A:1012141025938 10.1242/jcs.102.3.581 10.1016/j.bbrc.2012.01.155 |
| ContentType | Journal Article |
| Copyright | 2018 American Society for Pharmacology and Experimental Therapeutics Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics. Copyright Lippincott Williams & Wilkins Ovid Technologies Nov 1, 2018 Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics 2018 |
| Copyright_xml | – notice: 2018 American Society for Pharmacology and Experimental Therapeutics – notice: Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics. – notice: Copyright Lippincott Williams & Wilkins Ovid Technologies Nov 1, 2018 – notice: Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics 2018 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QO 7TK 7U7 8FD C1K FR3 P64 7X8 5PM |
| DOI | 10.1124/dmd.118.083402 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Biotechnology Research Abstracts Neurosciences Abstracts Toxicology Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Biotechnology Research Abstracts Technology Research Database Toxicology Abstracts Engineering Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Biotechnology Research Abstracts MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology Medicine |
| DocumentTitleAlternate | A Practical Guide to Pharmacomicrobiomics |
| EISSN | 1521-009X |
| EndPage | 1595 |
| ExternalDocumentID | PMC7333656 30111623 10_1124_dmd_118_083402 S009095562405640X |
| Genre | Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: P30 DK098722 – fundername: CIHR – fundername: NIGMS NIH HHS grantid: T32 GM007175 – fundername: NHLBI NIH HHS grantid: R01 HL122593 |
| GroupedDBID | --- .GJ 0R~ 18M 2WC 4.4 53G 5GY 5RE 5VS AAXUO ABJNI ABSQV ACGFO ACGFS ACIWK ACPRK ADBBV AENEX AERNN AFFNX AFOSN AFRAH AI. ALMA_UNASSIGNED_HOLDINGS BAWUL BTFSW CS3 DIK DU5 E3Z EBS EJD F5P F9R FDB GX1 H13 HZ~ IH2 INIJC KQ8 LSO M41 O9- OK1 P2P R0Z RHI ROL RPT SJN TR2 VH1 W8F WH7 WOQ YCJ YHG ZGI ZXP ~KM AALRI AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QO 7TK 7U7 8FD C1K FR3 P64 7X8 5PM |
| ID | FETCH-LOGICAL-c467t-5e274a34d0c44ce4003da5f2673404d3d0a02471e5fdd78fbcdc9e1cc11ad45a3 |
| ISSN | 0090-9556 1521-009X |
| IngestDate | Thu Aug 21 18:30:39 EDT 2025 Fri Jul 11 03:37:45 EDT 2025 Mon Jun 30 12:00:49 EDT 2025 Mon Jul 21 05:43:53 EDT 2025 Tue Jul 01 05:43:14 EDT 2025 Thu Apr 24 23:02:50 EDT 2025 Sun Apr 06 06:53:02 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | BBB PXR |
| Language | English |
| License | Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c467t-5e274a34d0c44ce4003da5f2673404d3d0a02471e5fdd78fbcdc9e1cc11ad45a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0002-0888-2875 |
| OpenAccessLink | https://dmd.aspetjournals.org/content/dmd/46/11/1588.full.pdf |
| PMID | 30111623 |
| PQID | 2164529827 |
| PQPubID | 2048316 |
| PageCount | 8 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7333656 proquest_miscellaneous_2089290975 proquest_journals_2164529827 pubmed_primary_30111623 crossref_citationtrail_10_1124_dmd_118_083402 crossref_primary_10_1124_dmd_118_083402 elsevier_sciencedirect_doi_10_1124_dmd_118_083402 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | November 2018 2018-11-00 20181101 |
| PublicationDateYYYYMMDD | 2018-11-01 |
| PublicationDate_xml | – month: 11 year: 2018 text: November 2018 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Bethesda – name: Bethesda, MD |
| PublicationTitle | Drug metabolism and disposition |
| PublicationTitleAlternate | Drug Metab Dispos |
| PublicationYear | 2018 |
| Publisher | Elsevier Inc American Society for Pharmacology and Experimental Therapeutics, Inc The American Society for Pharmacology and Experimental Therapeutics |
| Publisher_xml | – name: Elsevier Inc – name: American Society for Pharmacology and Experimental Therapeutics, Inc – name: The American Society for Pharmacology and Experimental Therapeutics |
| References | Valerino, Johns, Zaharko, Oliverio (bib89) 1972; 21 Lavrijsen, van Dyck, van Houdt, Hendrickx, Monbaliu, Woestenborghs, Meuldermans, Heykants (bib48) 1995; 23 Xiao, Feng, Liang, Sonne, Xia, Qiu, Li, Long, Zhang, Zhang (bib96) 2015; 33 Miller (bib57) 2010; 31 Watanabe, Yamashita, Furuno, Kawasaki, Gomita (bib92) 1995; 84 Wells, Mackenzie, Chowdhury, Guillemette, Gregory, Ishii, Hansen, Kessler, Kim, Chowdhury (bib93) 2004; 32 Kim, Hyun, Shim, Kobashi (bib35) 1992; 59 Whirl-Carrillo, McDonagh, Hebert, Gong, Sangkuhl, Thorn, Altman, Klein (bib94) 2012; 92 Artursson, Palm, Luthman (bib2) 2001; 46 Shelton, Karns, McCarty, Durham (bib79) 1997; 63 Claus, Ellero, Berger, Krause, Bruttin, Molina, Paris, Want, de Waziers, Cloarec (bib10) 2011; 2 Hattori, Namba, Akao, Kobashi (bib28) 1988; 36 6:263ra158. Crews, Gaedigk, Dunnenberger, Klein, Shen, Callaghan, Kharasch, Skaar (bib13) 2012; 91 Zoetendal, Raes, van den Bogert, Arumugam, Booijink, Troost, Bork, Wels, de Vos, Kleerebezem (bib101) 2012; 6 Dorfman (bib17) 1943; 14 DeBruyne, Weaver, Dallmann (bib14) 2014; 29 Lagier, Khelaifia, Alou, Ndongo, Dione, Hugon, Caputo, Cadoret, Traore, Seck (bib44) 2016; 1 Maier, Pruteanu, Kuhn, Zeller, Telzerow, Anderson, Brochado, Fernandez, Dose, Mori (bib54) 2018; 555 Hooper, Wong, Thelin, Hansson, Falk, Gordon (bib32) 2001; 291 Miniats, Jol (bib58) 1978; 42 Hibberd, Wu, Rodionov, Li, Cheng, Griffin, Barratt, Giannone, Hettich, Osterman (bib30) 2017; 9 Kim, Choi, Jeong, Lim, Kim, Yoo, Kim (bib37) 2018; 46 Pastan, Gottesman, Ueda, Lovelace, Rutherford, Willingham (bib63) 1988; 85 Li, Xu, Lai, Whitcher-Johnstone, Tweedie (bib49) 2012; 40 Yoo, Kim, Van Le, Jung, Yoo, Kim (bib99) 2014; 42 Hammarlund-Udenaes, de Lange, Thorne (bib26) 2013 Ramesh, Kozhaya, McKevitt, Djuretic, Carlson, Quintero, McCauley, Abreu, Unutmaz, Sundrud (bib70) 2014; 211 Powis, Ames, Kovach (bib67) 1979; 39 Relling, Evans (bib71) 2015; 526 Koch, Goldman (bib40) 1979; 208 Tamae, Liu, Kim, Sitz, Hong, Becket, Bui, Solaimani, Tran, Yang (bib86) 2008; 190 Elmer, Remmel (bib18) 1984; 14 Guthrie, Gupta, Daily, Kelly (bib24) 2017; 3 Liu, Li, Huang (bib51) 1999; 13 Koppel, Bisanz, Pandelia, Turnbaugh, Balskus (bib42) 2018; 7 Williams (bib95) 2014; 111 Allen-Vercoe (bib1) 2013; 16 Scott, Quintaneiro, Norvaisas, Lui, Wilson, Leung, Herrera-Dominguez, Sudiwala, Pessia, Clayton (bib76) 2017; 169 Shu, Kingston, Van Tassell, Wilkins (bib80) 1991; 21 Cheng, Ma, Krausz, Idle, Gonzalez (bib9) 2009; 37 Hoffmeyer, Burk, von Richter, Arnold, Brockmöller, Johne, Cascorbi, Gerloff, Roots, Eichelbaum (bib31) 2000; 97 Riley, Lizotte-Waniewski (bib72) 2009; 532 Hebert, Easterling, Kirby, Carr, Buchanan, Rutherford, Thummel, Fishbein, Unadkat (bib29) 2008; 84 Zhang, Widmer, Tzipori (bib100) 2013; 4 Lundberg, Toft, August, Hansen, Hansen (bib52) 2016; 7 Peterson, Mooseker (bib65) 1992; 102 Hoyles, Snelling, Umlai, Nicholson, Carding, Glen, McArthur (bib33) 2018; 6 Kitamura, Sugihara, Kuwasako, Tatsumi (bib38) 1997; 49 Wallace, Wang, Lane, Scott, Orans, Koo, Venkatesh, Jobin, Yeh, Mani (bib91) 2010; 330 Caldwell, Hawksworth (bib8) 1973; 25 Rafii, Sutherland, Hansen, Cerniglia (bib69) 1997; 25 Saha, Butler, Neu, Lindenbaum (bib74) 1983; 220 Tamura, Gold, Ferro-Luzzi, Ames (bib87) 1980; 77 Haiser, Gootenberg, Chatman, Sirasani, Balskus, Turnbaugh (bib25) 2013; 341 Strong, Renwick, George, Liu, Hill (bib84) 1987; 17 Harris, Manning, Federle, Diasio (bib27) 1986; 29 Peppercorn, Goldman (bib64) 1972; 181 Venkatesh, Mukherjee, Wang, Li, Sun, Benechet, Qiu, Maher, Redinbo, Phillips (bib90) 2014; 41 Frank, Hennenberg, Eyking, Rünzi, Gerken, Scott, Parkhill, Walker, Cario (bib19) 2015; 194 Staley, Kaiser, Beura, Hamilton, Weingarden, Bobr, Kang, Masopust, Sadowsky, Khoruts (bib83) 2017; 5 Ding, Baumdicker, Neher (bib16) 2018; 46 Lindenbaum, Rund, Butler, Tse-Eng, Saha (bib50) 1981; 305 Nayfach, Fischbach, Pollard (bib61) 2015; 31 Mizutani, Nakamura, Morikawa, Fukuda, Mochizuki, Yamauchi, Nozaki, Yui, Nemoto, Nagaishi (bib59) 2012; 419 García-González, Ritter, Shrestha, Andersen, Yilmaz, Walhout (bib22) 2017; 169 Basit, Lacey (bib3) 2001; 227 Yeo, Hyun, Jang, Han, Lee, Kim (bib97) 2012; 22 Koch, Beaulieu, Goldman (bib39) 1980; 29 Rizkallah, Saad, Aziz (bib73) 2010; 8 Selwyn, Cui, Klaassen (bib77) 2015; 43 Shah, Fritz, Glaab, Desai, Greenhalgh, Frachet, Niegowska, Estes, Jäger, Seguin-Devaux (bib78) 2016; 7 Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Tóth M, Korecka A, Bakocevic N, Ng LG, Kundu P et al. (2014) The gut microbiota influences blood-brain barrier permeability in mice [published correction appears in Sci Transl Med (2014) 6:266er7]. Deng, Rogers, Sychterz, Talley, Qian, Bershas, Ho, Shi, Chen, Serabjit-Singh (bib15) 2011; 39 Goodman, Kallstrom, Faith, Reyes, Moore, Dantas, Gordon (bib23) 2011; 108 Tripathi, Debelius, Brenner, Karin, Loomba, Schnabl, Knight (bib88) 2018; 15 Fröhlich, Farzi, Mayerhofer, Reichmann, Jačan, Wagner, Zinser, Bordag, Magnes, Fröhlich (bib20) 2016; 56 Fuller (bib21) 1937; 229 Sasaki, Tamura, Shibakawa, Fujita, Murakami, Yamamoto, Muranishi (bib75) 1997; 14 Bhatt, Gunasekara, Speer, Reed, Peña, Midkiff, Magness, Bultman, Allbritton, Redinbo (bib5) 2018; 4 Larsson, Tremaroli, Lee, Koren, Nookaew, Fricker, Nielsen, Ley, Bäckhed (bib47) 2012; 61 Krämer, Green, Pollard, Tugendreich (bib43) 2014; 30 Powell, Leonard, Kwong, Engel, Moran (bib66) 2016; 113 Okuda, Ogura, Kato, Takubo, Watabe (bib62) 1998; 287 Hubbard, Murray, Bisson, Lahoti, Gowda, Amin, Patterson, Perdew (bib34) 2015; 5 Maurice, Haiser, Turnbaugh (bib55) 2013; 152 Spanogiannopoulos, Bess, Carmody, Turnbaugh (bib82) 2016; 14 Kim, Ingber (bib36) 2013; 5 Larson, Banks, Sherman, Rothenberg (bib46) 2012; 17 Qin, Li, Raes, Arumugam, Burgdorf, Manichanh, Nielsen, Pons, Levenez, Yamada (bib68) 2010; 464 Yip, Aw, Lee, Hong, Ku, Xu, Chan, Cheong, Chng, Ng (bib98) 2018; 67 Basit, Newton, Lacey (bib4) 2002; 237 Kola, Landis (bib41) 2004; 3 Bisanz, Soto-Perez, Lam, Bess, Haiser, Allen-Vercoe, Rekdal, Balskus, Turnbaugh (bib6) 2018 Smith, Griffiths (bib81) 1974; 4 Clayton, Baker, Lindon, Everett, Nicholson (bib11) 2009; 106 Ma, Shah, Cheung, Guo, Feigenbaum, Krausz, Idle, Gonzalez (bib53) 2007; 35 Lam, Martens, Charles (bib45) 2018; 3 Cory, He, Winchester, Kumar, Fletcher (bib12) 2016; 33 McCabe, Sane, Keith-Luzzi, Xu, King, Whitcher-Johnstone, Johnstone, Tweedie, Li (bib56) 2015; 43 Subramanian, Sabui, Moradi, Marchant, Said (bib85) 2018; 1860 Nakayama, Kinouchi, Kataoka, Akimoto, Matsuda, Ohnishi (bib60) 1997; 7 Zoetendal (10.1124/dmd.118.083402_bib101) 2012; 6 Spanogiannopoulos (10.1124/dmd.118.083402_bib82) 2016; 14 Deng (10.1124/dmd.118.083402_bib15) 2011; 39 Pastan (10.1124/dmd.118.083402_bib63) 1988; 85 Tamae (10.1124/dmd.118.083402_bib86) 2008; 190 Miniats (10.1124/dmd.118.083402_bib58) 1978; 42 Saha (10.1124/dmd.118.083402_bib74) 1983; 220 Ding (10.1124/dmd.118.083402_bib16) 2018; 46 Valerino (10.1124/dmd.118.083402_bib89) 1972; 21 Allen-Vercoe (10.1124/dmd.118.083402_bib1) 2013; 16 Bisanz (10.1124/dmd.118.083402_bib6) 2018 Cheng (10.1124/dmd.118.083402_bib9) 2009; 37 Guthrie (10.1124/dmd.118.083402_bib24) 2017; 3 Subramanian (10.1124/dmd.118.083402_bib85) 2018; 1860 Koch (10.1124/dmd.118.083402_bib40) 1979; 208 Harris (10.1124/dmd.118.083402_bib27) 1986; 29 Lam (10.1124/dmd.118.083402_bib45) 2018; 3 Maier (10.1124/dmd.118.083402_bib54) 2018; 555 Frank (10.1124/dmd.118.083402_bib19) 2015; 194 10.1124/dmd.118.083402_bib7 McCabe (10.1124/dmd.118.083402_bib56) 2015; 43 Claus (10.1124/dmd.118.083402_bib10) 2011; 2 Tamura (10.1124/dmd.118.083402_bib87) 1980; 77 Lundberg (10.1124/dmd.118.083402_bib52) 2016; 7 Miller (10.1124/dmd.118.083402_bib57) 2010; 31 Wallace (10.1124/dmd.118.083402_bib91) 2010; 330 Fröhlich (10.1124/dmd.118.083402_bib20) 2016; 56 Smith (10.1124/dmd.118.083402_bib81) 1974; 4 Staley (10.1124/dmd.118.083402_bib83) 2017; 5 Nayfach (10.1124/dmd.118.083402_bib61) 2015; 31 Yip (10.1124/dmd.118.083402_bib98) 2018; 67 Kola (10.1124/dmd.118.083402_bib41) 2004; 3 Artursson (10.1124/dmd.118.083402_bib2) 2001; 46 Larsson (10.1124/dmd.118.083402_bib47) 2012; 61 Rafii (10.1124/dmd.118.083402_bib69) 1997; 25 Krämer (10.1124/dmd.118.083402_bib43) 2014; 30 Bhatt (10.1124/dmd.118.083402_bib5) 2018; 4 Hammarlund-Udenaes (10.1124/dmd.118.083402_bib26) 2013 Haiser (10.1124/dmd.118.083402_bib25) 2013; 341 Hooper (10.1124/dmd.118.083402_bib32) 2001; 291 Elmer (10.1124/dmd.118.083402_bib18) 1984; 14 Powell (10.1124/dmd.118.083402_bib66) 2016; 113 Relling (10.1124/dmd.118.083402_bib71) 2015; 526 Venkatesh (10.1124/dmd.118.083402_bib90) 2014; 41 Hebert (10.1124/dmd.118.083402_bib29) 2008; 84 Rizkallah (10.1124/dmd.118.083402_bib73) 2010; 8 Crews (10.1124/dmd.118.083402_bib13) 2012; 91 Kim (10.1124/dmd.118.083402_bib36) 2013; 5 Basit (10.1124/dmd.118.083402_bib4) 2002; 237 Yeo (10.1124/dmd.118.083402_bib97) 2012; 22 Kim (10.1124/dmd.118.083402_bib37) 2018; 46 Hattori (10.1124/dmd.118.083402_bib28) 1988; 36 Nakayama (10.1124/dmd.118.083402_bib60) 1997; 7 Qin (10.1124/dmd.118.083402_bib68) 2010; 464 Xiao (10.1124/dmd.118.083402_bib96) 2015; 33 Clayton (10.1124/dmd.118.083402_bib11) 2009; 106 Selwyn (10.1124/dmd.118.083402_bib77) 2015; 43 Tripathi (10.1124/dmd.118.083402_bib88) 2018; 15 Maurice (10.1124/dmd.118.083402_bib55) 2013; 152 Koppel (10.1124/dmd.118.083402_bib42) 2018; 7 Wells (10.1124/dmd.118.083402_bib93) 2004; 32 Sasaki (10.1124/dmd.118.083402_bib75) 1997; 14 Larson (10.1124/dmd.118.083402_bib46) 2012; 17 Okuda (10.1124/dmd.118.083402_bib62) 1998; 287 Kitamura (10.1124/dmd.118.083402_bib38) 1997; 49 Shu (10.1124/dmd.118.083402_bib80) 1991; 21 Hubbard (10.1124/dmd.118.083402_bib34) 2015; 5 Yoo (10.1124/dmd.118.083402_bib99) 2014; 42 Williams (10.1124/dmd.118.083402_bib95) 2014; 111 Ramesh (10.1124/dmd.118.083402_bib70) 2014; 211 Hibberd (10.1124/dmd.118.083402_bib30) 2017; 9 Whirl-Carrillo (10.1124/dmd.118.083402_bib94) 2012; 92 Basit (10.1124/dmd.118.083402_bib3) 2001; 227 Li (10.1124/dmd.118.083402_bib49) 2012; 40 Kim (10.1124/dmd.118.083402_bib35) 1992; 59 Peppercorn (10.1124/dmd.118.083402_bib64) 1972; 181 Riley (10.1124/dmd.118.083402_bib72) 2009; 532 García-González (10.1124/dmd.118.083402_bib22) 2017; 169 Lavrijsen (10.1124/dmd.118.083402_bib48) 1995; 23 Ma (10.1124/dmd.118.083402_bib53) 2007; 35 Peterson (10.1124/dmd.118.083402_bib65) 1992; 102 Shelton (10.1124/dmd.118.083402_bib79) 1997; 63 Caldwell (10.1124/dmd.118.083402_bib8) 1973; 25 Lagier (10.1124/dmd.118.083402_bib44) 2016; 1 DeBruyne (10.1124/dmd.118.083402_bib14) 2014; 29 Zhang (10.1124/dmd.118.083402_bib100) 2013; 4 Strong (10.1124/dmd.118.083402_bib84) 1987; 17 Liu (10.1124/dmd.118.083402_bib51) 1999; 13 Hoyles (10.1124/dmd.118.083402_bib33) 2018; 6 Watanabe (10.1124/dmd.118.083402_bib92) 1995; 84 Fuller (10.1124/dmd.118.083402_bib21) 1937; 229 Goodman (10.1124/dmd.118.083402_bib23) 2011; 108 Koch (10.1124/dmd.118.083402_bib39) 1980; 29 Lindenbaum (10.1124/dmd.118.083402_bib50) 1981; 305 Shah (10.1124/dmd.118.083402_bib78) 2016; 7 Hoffmeyer (10.1124/dmd.118.083402_bib31) 2000; 97 Cory (10.1124/dmd.118.083402_bib12) 2016; 33 Dorfman (10.1124/dmd.118.083402_bib17) 1943; 14 Scott (10.1124/dmd.118.083402_bib76) 2017; 169 Powis (10.1124/dmd.118.083402_bib67) 1979; 39 Mizutani (10.1124/dmd.118.083402_bib59) 2012; 419 |
| References_xml | – volume: 25 start-page: 422 year: 1973 end-page: 424 ident: bib8 article-title: The demethylation of methamphetamine by intestinal microflora publication-title: J Pharm Pharmacol – volume: 56 start-page: 140 year: 2016 end-page: 155 ident: bib20 article-title: Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication publication-title: Brain Behav Immun – volume: 113 start-page: 13887 year: 2016 end-page: 13892 ident: bib66 article-title: Genome-wide screen identifies host colonization determinants in a bacterial gut symbiont publication-title: Proc Natl Acad Sci USA – volume: 22 start-page: 838 year: 2012 end-page: 848 ident: bib97 article-title: Development of fecal microbial enzyme mix for mutagenicity assay of natural products publication-title: J Microbiol Biotechnol – volume: 21 start-page: 737 year: 1991 end-page: 750 ident: bib80 article-title: Metabolism of levamisole, an anti-colon cancer drug, by human intestinal bacteria publication-title: Xenobiotica – year: 2018 ident: bib6 article-title: Illuminating the microbiome’s dark matter: a functional genomic toolkit for the study of human gut actinobacteria publication-title: bioRxiv – volume: 194 start-page: 1983 year: 2015 end-page: 1995 ident: bib19 article-title: TLR signaling modulates side effects of anticancer therapy in the small intestine publication-title: J Immunol – volume: 91 start-page: 321 year: 2012 end-page: 326 ident: bib13 article-title: ) genotype publication-title: Clin Pharmacol Ther – volume: 31 start-page: 3368 year: 2015 end-page: 3370 ident: bib61 article-title: MetaQuery: a web server for rapid annotation and quantitative analysis of specific genes in the human gut microbiome publication-title: Bioinformatics – volume: 59 start-page: 1 year: 1992 end-page: 5 ident: bib35 article-title: The role of intestinal bacteria in the transformation of sodium picosulfate publication-title: Jpn J Pharmacol – volume: 30 start-page: 523 year: 2014 end-page: 530 ident: bib43 article-title: Causal analysis approaches in ingenuity pathway analysis publication-title: Bioinformatics – volume: 33 start-page: 1103 year: 2015 end-page: 1108 ident: bib96 article-title: A catalog of the mouse gut metagenome publication-title: Nat Biotechnol – volume: 237 start-page: 23 year: 2002 end-page: 33 ident: bib4 article-title: Susceptibility of the H publication-title: Int J Pharm – volume: 227 start-page: 157 year: 2001 end-page: 165 ident: bib3 article-title: Colonic metabolism of ranitidine: implications for its delivery and absorption publication-title: Int J Pharm – volume: 6 start-page: 55 year: 2018 ident: bib33 article-title: Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier publication-title: Microbiome – volume: 190 start-page: 5981 year: 2008 end-page: 5988 ident: bib86 article-title: Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli publication-title: J Bacteriol – volume: 220 start-page: 325 year: 1983 end-page: 327 ident: bib74 article-title: Digoxin-inactivating bacteria: identification in human gut flora publication-title: Science – volume: 111 start-page: 1661 year: 2014 ident: bib95 article-title: Gnotobiotics publication-title: Proc Natl Acad Sci USA – volume: 84 start-page: 248 year: 2008 end-page: 253 ident: bib29 article-title: Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study publication-title: Clin Pharmacol Ther – volume: 14 start-page: 1004 year: 1997 end-page: 1007 ident: bib75 article-title: Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms publication-title: Pharm Res – volume: 23 start-page: 354 year: 1995 end-page: 362 ident: bib48 article-title: Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans publication-title: Drug Metab Dispos – volume: 40 start-page: 1130 year: 2012 end-page: 1137 ident: bib49 article-title: Metabolic switching of BILR 355 in the presence of ritonavir. II. Uncovering novel contributions by gut bacteria and aldehyde oxidase publication-title: Drug Metab Dispos – volume: 2 year: 2011 ident: bib10 article-title: Colonization-induced host-gut microbial metabolic interaction publication-title: MBio – volume: 3 start-page: e00195-17 year: 2018 ident: bib45 article-title: system for function-based screening of DNA from the human gut microbiome publication-title: mSystems – volume: 35 start-page: 194 year: 2007 end-page: 200 ident: bib53 article-title: The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A publication-title: Drug Metab Dispos – volume: 7 start-page: e33953 year: 2018 ident: bib42 article-title: Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins publication-title: eLife – volume: 8 start-page: 182 year: 2010 end-page: 193 ident: bib73 article-title: The Human Microbiome Project, personalized medicine and the birth of pharmacomicrobiomics publication-title: Curr Pharmacogenomics Person Med – volume: 97 start-page: 3473 year: 2000 end-page: 3478 ident: bib31 article-title: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity publication-title: Proc Natl Acad Sci USA – volume: 25 start-page: S121 year: 1997 end-page: S122 ident: bib69 article-title: , a nitroreductase-producing bacterium isolated from the human intestinal tract publication-title: Clin Infect Dis – volume: 67 start-page: 282 year: 2018 end-page: 295 ident: bib98 article-title: The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat publication-title: Hepatology – volume: 1 start-page: 16203 year: 2016 ident: bib44 article-title: Culture of previously uncultured members of the human gut microbiota by culturomics publication-title: Nat Microbiol – volume: 305 start-page: 789 year: 1981 end-page: 794 ident: bib50 article-title: Inactivation of digoxin by the gut flora: reversal by antibiotic therapy publication-title: N Engl J Med – volume: 287 start-page: 791 year: 1998 end-page: 799 ident: bib62 article-title: A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs publication-title: J Pharmacol Exp Ther – volume: 17 start-page: 222 year: 2012 end-page: 232 ident: bib46 article-title: Automation of cell-based drug absorption assays in 96-well format using permeable support systems publication-title: J Lab Autom – volume: 169 start-page: 431 year: 2017 end-page: 441.e8 ident: bib22 article-title: response to cancer chemotherapeutics publication-title: Cell – reference: 6:263ra158. – volume: 181 start-page: 555 year: 1972 end-page: 562 ident: bib64 article-title: The role of intestinal bacteria in the metabolism of salicylazosulfapyridine publication-title: J Pharmacol Exp Ther – volume: 43 start-page: 1612 year: 2015 end-page: 1618 ident: bib56 article-title: studies publication-title: Drug Metab Dispos – volume: 21 start-page: 821 year: 1972 end-page: 831 ident: bib89 article-title: Studies of the metabolism of methotrexate by intestinal flora. I. Identification and study of biological properties of the metabolite 4-amino-4-deoxy-N publication-title: Biochem Pharmacol – volume: 92 start-page: 414 year: 2012 end-page: 417 ident: bib94 article-title: Pharmacogenomics knowledge for personalized medicine publication-title: Clin Pharmacol Ther – volume: 7 start-page: 11535 year: 2016 ident: bib78 article-title: A microfluidics-based in vitro model of the gastrointestinal human-microbe interface publication-title: Nat Commun – volume: 16 start-page: 625 year: 2013 end-page: 629 ident: bib1 article-title: Bringing the gut microbiota into focus through microbial culture: recent progress and future perspective publication-title: Curr Opin Microbiol – volume: 208 start-page: 406 year: 1979 end-page: 410 ident: bib40 article-title: The anaerobic metabolism of metronidazole forms N-(2-hydroxyethyl)-oxamic acid publication-title: J Pharmacol Exp Ther – volume: 13 start-page: 262 year: 1999 end-page: 266 ident: bib51 article-title: Determination of unbound drug concentration and protein-drug binding fraction in plasma publication-title: Biomed Chromatogr – volume: 1860 start-page: 556 year: 2018 end-page: 565 ident: bib85 article-title: Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanisms publication-title: Biochim Biophys Acta – volume: 49 start-page: 253 year: 1997 end-page: 256 ident: bib38 article-title: The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide publication-title: J Pharm Pharmacol – volume: 29 start-page: 44 year: 1986 end-page: 48 ident: bib27 article-title: Conversion of 5-fluorocytosine to 5-fluorouracil by human intestinal microflora publication-title: Antimicrob Agents Chemother – volume: 9 start-page: eaal4069 year: 2017 ident: bib30 article-title: The effects of micronutrient deficiencies on bacterial species from the human gut microbiota publication-title: Sci Transl Med – volume: 211 start-page: 89 year: 2014 end-page: 104 ident: bib70 article-title: Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids publication-title: J Exp Med – volume: 229 start-page: 194 year: 1937 end-page: 198 ident: bib21 article-title: Is p-aminobenzenesulphonamide the active agent in prontosil therapy? publication-title: Lancet – volume: 7 start-page: 68 year: 2016 end-page: 74 ident: bib52 article-title: Antibiotic-treated versus germ-free rodents for microbiota transplantation studies publication-title: Gut Microbes – volume: 526 start-page: 343 year: 2015 end-page: 350 ident: bib71 article-title: Pharmacogenomics in the clinic publication-title: Nature – volume: 555 start-page: 623 year: 2018 end-page: 628 ident: bib54 article-title: Extensive impact of non-antibiotic drugs on human gut bacteria publication-title: Nature – volume: 4 start-page: 477 year: 1974 end-page: 487 ident: bib81 article-title: Metabolism of N-acylated and O-alkylated drugs by the intestinal microflora during anaerobic incubation publication-title: Xenobiotica – volume: 6 start-page: 1415 year: 2012 end-page: 1426 ident: bib101 article-title: The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates publication-title: ISME J – volume: 5 start-page: 1130 year: 2013 end-page: 1140 ident: bib36 article-title: Gut-on-a-chip microenvironment induces human intestinal cells to undergo villus differentiation publication-title: Integr Biol – volume: 36 start-page: 172 year: 1988 end-page: 179 ident: bib28 article-title: Metabolism of sennosides by human intestinal bacteria publication-title: Pharmacology – volume: 63 start-page: 2832 year: 1997 end-page: 2835 ident: bib79 publication-title: Appl Environ Microbiol – volume: 152 start-page: 39 year: 2013 end-page: 50 ident: bib55 article-title: Xenobiotics shape the physiology and gene expression of the active human gut microbiome publication-title: Cell – volume: 77 start-page: 4961 year: 1980 end-page: 4965 ident: bib87 article-title: Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora publication-title: Proc Natl Acad Sci USA – volume: 291 start-page: 881 year: 2001 end-page: 884 ident: bib32 article-title: Molecular analysis of commensal host-microbial relationships in the intestine publication-title: Science – volume: 15 start-page: 397 year: 2018 end-page: 411 ident: bib88 article-title: The gut-liver axis and the intersection with the microbiome publication-title: Nat Rev Gastroenterol Hepatol – volume: 43 start-page: 1572 year: 2015 end-page: 1580 ident: bib77 article-title: RNA-Seq quantification of hepatic drug processing genes in germ-free mice publication-title: Drug Metab Dispos – volume: 419 start-page: 238 year: 2012 end-page: 243 ident: bib59 article-title: Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured publication-title: Biochem Biophys Res Commun – volume: 3 start-page: 27 year: 2017 ident: bib24 article-title: Human microbiome signatures of differential colorectal cancer drug metabolism publication-title: NPJ Biofilms Microbiomes – volume: 42 start-page: 428 year: 1978 end-page: 437 ident: bib58 article-title: Gnotobiotic pigs-derivation and rearing publication-title: Can J Comp Med – volume: 341 start-page: 295 year: 2013 end-page: 298 ident: bib25 publication-title: Science – volume: 42 start-page: 1508 year: 2014 end-page: 1513 ident: bib99 article-title: Gut microbiota-mediated drug interactions between lovastatin and antibiotics publication-title: Drug Metab Dispos – reference: Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Tóth M, Korecka A, Bakocevic N, Ng LG, Kundu P et al. (2014) The gut microbiota influences blood-brain barrier permeability in mice [published correction appears in Sci Transl Med (2014) 6:266er7]. – volume: 41 start-page: 296 year: 2014 end-page: 310 ident: bib90 article-title: Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4 publication-title: Immunity – volume: 32 start-page: 281 year: 2004 end-page: 290 ident: bib93 article-title: Glucuronidation and the UDP-glucuronosyltransferases in health and disease publication-title: Drug Metab Dispos – volume: 4 start-page: 193 year: 2013 end-page: 200 ident: bib100 article-title: A pig model of the human gastrointestinal tract publication-title: Gut Microbes – volume: 7 start-page: 35 year: 1997 end-page: 43 ident: bib60 article-title: Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil publication-title: Pharmacogenetics – volume: 37 start-page: 1611 year: 2009 end-page: 1621 ident: bib9 article-title: Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity publication-title: Drug Metab Dispos – volume: 39 start-page: 1747 year: 2011 end-page: 1754 ident: bib15 article-title: Investigations of hydrazine cleavage of eltrombopag in humans publication-title: Drug Metab Dispos – volume: 330 start-page: 831 year: 2010 end-page: 835 ident: bib91 article-title: Alleviating cancer drug toxicity by inhibiting a bacterial enzyme publication-title: Science – volume: 46 start-page: e5 year: 2018 ident: bib16 article-title: panX: pan-genome analysis and exploration publication-title: Nucleic Acids Res – volume: 61 start-page: 1124 year: 2012 end-page: 1131 ident: bib47 publication-title: Gut – volume: 17 start-page: 685 year: 1987 end-page: 696 ident: bib84 article-title: The reduction of sulphinpyrazone and sulindac by intestinal bacteria publication-title: Xenobiotica – volume: 29 start-page: 277 year: 2014 end-page: 287 ident: bib14 article-title: The hepatic circadian clock modulates xenobiotic metabolism in mice publication-title: J Biol Rhythms – volume: 84 start-page: 516 year: 1995 end-page: 517 ident: bib92 article-title: Metabolism of omeprazole by gut flora in rats publication-title: J Pharm Sci – volume: 46 start-page: 122 year: 2018 end-page: 130 ident: bib37 article-title: Effect of probiotics on pharmacokinetics of orally administered acetaminophen in mice publication-title: Drug Metab Dispos – volume: 29 start-page: 3281 year: 1980 end-page: 3284 ident: bib39 article-title: Role of the intestinal flora in the metabolism of misonidazole publication-title: Biochem Pharmacol – volume: 102 start-page: 581 year: 1992 end-page: 600 ident: bib65 article-title: Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2 publication-title: J Cell Sci – volume: 3 start-page: 711 year: 2004 end-page: 715 ident: bib41 article-title: Can the pharmaceutical industry reduce attrition rates? publication-title: Nat Rev Drug Discov – volume: 5 start-page: 87 year: 2017 ident: bib83 article-title: Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning publication-title: Microbiome – volume: 31 start-page: 246 year: 2010 end-page: 254 ident: bib57 article-title: Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier publication-title: Trends Pharmacol Sci – volume: 85 start-page: 4486 year: 1988 end-page: 4490 ident: bib63 article-title: A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells publication-title: Proc Natl Acad Sci USA – volume: 108 start-page: 6252 year: 2011 end-page: 6257 ident: bib23 article-title: Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice publication-title: Proc Natl Acad Sci USA – volume: 14 start-page: 829 year: 1984 end-page: 840 ident: bib18 article-title: Role of the intestinal microflora in clonazepam metabolism in the rat publication-title: Xenobiotica – volume: 169 start-page: 442 year: 2017 end-page: 456.e18 ident: bib76 article-title: Host-microbe co-metabolism dictates cancer drug efficacy in publication-title: Cell – volume: 46 start-page: 27 year: 2001 end-page: 43 ident: bib2 article-title: Caco-2 monolayers in experimental and theoretical predictions of drug transport publication-title: Adv Drug Deliv Rev – year: 2013 ident: bib26 publication-title: Drug Delivery to the Brain – volume: 464 start-page: 59 year: 2010 end-page: 65 ident: bib68 article-title: A human gut microbial gene catalogue established by metagenomic sequencing publication-title: Nature – volume: 4 start-page: 46 year: 2018 end-page: 52 ident: bib5 article-title: Nonsteroidal anti-inflammatory drug-induced leaky gut modeled using polarized monolayers of primary human intestinal epithelial cells publication-title: ACS Infect Dis – volume: 106 start-page: 14728 year: 2009 end-page: 14733 ident: bib11 article-title: Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism publication-title: Proc Natl Acad Sci USA – volume: 33 start-page: 2713 year: 2016 end-page: 2721 ident: bib12 article-title: Alterations in p-glycoprotein expression and function between macrophage subsets publication-title: Pharm Res – volume: 39 start-page: 3564 year: 1979 end-page: 3570 ident: bib67 article-title: Metabolic conversion of indicine N-oxide to indicine in rabbits and humans publication-title: Cancer Res – volume: 14 start-page: 273 year: 2016 end-page: 287 ident: bib82 article-title: The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism publication-title: Nat Rev Microbiol – volume: 5 start-page: 12689 year: 2015 ident: bib34 article-title: Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles publication-title: Sci Rep – volume: 14 start-page: 436 year: 1943 end-page: 440 ident: bib17 article-title: The detection of defective members of large populations publication-title: Ann Math Stat – volume: 532 start-page: 367 year: 2009 end-page: 377 ident: bib72 article-title: Population genomics and the bacterial species concept publication-title: Methods Mol Biol – volume: 43 start-page: 1612 year: 2015 ident: 10.1124/dmd.118.083402_bib56 article-title: in vitro in vivo studies publication-title: Drug Metab Dispos doi: 10.1124/dmd.115.064477 – volume: 3 start-page: e00195-17 year: 2018 ident: 10.1124/dmd.118.083402_bib45 article-title: Bacteroides system for function-based screening of DNA from the human gut microbiome publication-title: mSystems doi: 10.1128/mSystems.00195-17 – volume: 77 start-page: 4961 year: 1980 ident: 10.1124/dmd.118.083402_bib87 article-title: Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.77.8.4961 – volume: 532 start-page: 367 year: 2009 ident: 10.1124/dmd.118.083402_bib72 article-title: Population genomics and the bacterial species concept publication-title: Methods Mol Biol doi: 10.1007/978-1-60327-853-9_21 – volume: 29 start-page: 3281 year: 1980 ident: 10.1124/dmd.118.083402_bib39 article-title: Role of the intestinal flora in the metabolism of misonidazole publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(80)90304-4 – volume: 14 start-page: 436 year: 1943 ident: 10.1124/dmd.118.083402_bib17 article-title: The detection of defective members of large populations publication-title: Ann Math Stat doi: 10.1214/aoms/1177731363 – volume: 341 start-page: 295 year: 2013 ident: 10.1124/dmd.118.083402_bib25 article-title: Eggerthella lenta publication-title: Science doi: 10.1126/science.1235872 – volume: 106 start-page: 14728 year: 2009 ident: 10.1124/dmd.118.083402_bib11 article-title: Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0904489106 – volume: 211 start-page: 89 year: 2014 ident: 10.1124/dmd.118.083402_bib70 article-title: Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids publication-title: J Exp Med doi: 10.1084/jem.20130301 – volume: 36 start-page: 172 issue: Suppl 1 year: 1988 ident: 10.1124/dmd.118.083402_bib28 article-title: Metabolism of sennosides by human intestinal bacteria publication-title: Pharmacology doi: 10.1159/000138437 – volume: 220 start-page: 325 year: 1983 ident: 10.1124/dmd.118.083402_bib74 article-title: Digoxin-inactivating bacteria: identification in human gut flora publication-title: Science doi: 10.1126/science.6836275 – volume: 2 year: 2011 ident: 10.1124/dmd.118.083402_bib10 article-title: Colonization-induced host-gut microbial metabolic interaction publication-title: MBio doi: 10.1128/mBio.00271-10 – volume: 14 start-page: 829 year: 1984 ident: 10.1124/dmd.118.083402_bib18 article-title: Role of the intestinal microflora in clonazepam metabolism in the rat publication-title: Xenobiotica doi: 10.3109/00498258409151481 – volume: 59 start-page: 1 year: 1992 ident: 10.1124/dmd.118.083402_bib35 article-title: The role of intestinal bacteria in the transformation of sodium picosulfate publication-title: Jpn J Pharmacol doi: 10.1254/jjp.59.1 – volume: 8 start-page: 182 year: 2010 ident: 10.1124/dmd.118.083402_bib73 article-title: The Human Microbiome Project, personalized medicine and the birth of pharmacomicrobiomics publication-title: Curr Pharmacogenomics Person Med doi: 10.2174/187569210792246326 – volume: 291 start-page: 881 year: 2001 ident: 10.1124/dmd.118.083402_bib32 article-title: Molecular analysis of commensal host-microbial relationships in the intestine publication-title: Science doi: 10.1126/science.291.5505.881 – volume: 63 start-page: 2832 year: 1997 ident: 10.1124/dmd.118.083402_bib79 article-title: Klebsiella terragena publication-title: Appl Environ Microbiol doi: 10.1128/aem.63.7.2832-2835.1997 – volume: 35 start-page: 194 year: 2007 ident: 10.1124/dmd.118.083402_bib53 article-title: The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A publication-title: Drug Metab Dispos doi: 10.1124/dmd.106.012831 – volume: 3 start-page: 711 year: 2004 ident: 10.1124/dmd.118.083402_bib41 article-title: Can the pharmaceutical industry reduce attrition rates? publication-title: Nat Rev Drug Discov doi: 10.1038/nrd1470 – volume: 46 start-page: 122 year: 2018 ident: 10.1124/dmd.118.083402_bib37 article-title: Effect of probiotics on pharmacokinetics of orally administered acetaminophen in mice publication-title: Drug Metab Dispos doi: 10.1124/dmd.117.077222 – volume: 92 start-page: 414 year: 2012 ident: 10.1124/dmd.118.083402_bib94 article-title: Pharmacogenomics knowledge for personalized medicine publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2012.96 – volume: 41 start-page: 296 year: 2014 ident: 10.1124/dmd.118.083402_bib90 article-title: Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4 publication-title: Immunity doi: 10.1016/j.immuni.2014.06.014 – volume: 49 start-page: 253 year: 1997 ident: 10.1124/dmd.118.083402_bib38 article-title: The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide publication-title: J Pharm Pharmacol doi: 10.1111/j.2042-7158.1997.tb06790.x – volume: 23 start-page: 354 year: 1995 ident: 10.1124/dmd.118.083402_bib48 article-title: Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans publication-title: Drug Metab Dispos doi: 10.1016/S0090-9556(25)06545-6 – volume: 208 start-page: 406 year: 1979 ident: 10.1124/dmd.118.083402_bib40 article-title: The anaerobic metabolism of metronidazole forms N-(2-hydroxyethyl)-oxamic acid publication-title: J Pharmacol Exp Ther doi: 10.1016/S0022-3565(25)31588-0 – ident: 10.1124/dmd.118.083402_bib7 doi: 10.1126/scitranslmed.3009759 – year: 2013 ident: 10.1124/dmd.118.083402_bib26 – volume: 3 start-page: 27 year: 2017 ident: 10.1124/dmd.118.083402_bib24 article-title: Human microbiome signatures of differential colorectal cancer drug metabolism publication-title: NPJ Biofilms Microbiomes doi: 10.1038/s41522-017-0034-1 – volume: 6 start-page: 55 year: 2018 ident: 10.1124/dmd.118.083402_bib33 article-title: Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier publication-title: Microbiome doi: 10.1186/s40168-018-0439-y – volume: 32 start-page: 281 year: 2004 ident: 10.1124/dmd.118.083402_bib93 article-title: Glucuronidation and the UDP-glucuronosyltransferases in health and disease publication-title: Drug Metab Dispos doi: 10.1124/dmd.32.3.281 – volume: 1860 start-page: 556 year: 2018 ident: 10.1124/dmd.118.083402_bib85 article-title: Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanisms publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamem.2017.10.010 – volume: 29 start-page: 277 year: 2014 ident: 10.1124/dmd.118.083402_bib14 article-title: The hepatic circadian clock modulates xenobiotic metabolism in mice publication-title: J Biol Rhythms doi: 10.1177/0748730414544740 – volume: 33 start-page: 1103 year: 2015 ident: 10.1124/dmd.118.083402_bib96 article-title: A catalog of the mouse gut metagenome publication-title: Nat Biotechnol doi: 10.1038/nbt.3353 – volume: 56 start-page: 140 year: 2016 ident: 10.1124/dmd.118.083402_bib20 article-title: Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2016.02.020 – volume: 85 start-page: 4486 year: 1988 ident: 10.1124/dmd.118.083402_bib63 article-title: A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.85.12.4486 – volume: 5 start-page: 1130 year: 2013 ident: 10.1124/dmd.118.083402_bib36 article-title: Gut-on-a-chip microenvironment induces human intestinal cells to undergo villus differentiation publication-title: Integr Biol doi: 10.1039/c3ib40126j – volume: 29 start-page: 44 year: 1986 ident: 10.1124/dmd.118.083402_bib27 article-title: Conversion of 5-fluorocytosine to 5-fluorouracil by human intestinal microflora publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.29.1.44 – volume: 61 start-page: 1124 year: 2012 ident: 10.1124/dmd.118.083402_bib47 article-title: MyD88 publication-title: Gut doi: 10.1136/gutjnl-2011-301104 – volume: 21 start-page: 737 year: 1991 ident: 10.1124/dmd.118.083402_bib80 article-title: Metabolism of levamisole, an anti-colon cancer drug, by human intestinal bacteria publication-title: Xenobiotica doi: 10.3109/00498259109039513 – volume: 181 start-page: 555 year: 1972 ident: 10.1124/dmd.118.083402_bib64 article-title: The role of intestinal bacteria in the metabolism of salicylazosulfapyridine publication-title: J Pharmacol Exp Ther doi: 10.1016/S0022-3565(25)29238-2 – volume: 30 start-page: 523 year: 2014 ident: 10.1124/dmd.118.083402_bib43 article-title: Causal analysis approaches in ingenuity pathway analysis publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt703 – volume: 33 start-page: 2713 year: 2016 ident: 10.1124/dmd.118.083402_bib12 article-title: Alterations in p-glycoprotein expression and function between macrophage subsets publication-title: Pharm Res doi: 10.1007/s11095-016-1998-x – volume: 108 start-page: 6252 year: 2011 ident: 10.1124/dmd.118.083402_bib23 article-title: Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1102938108 – volume: 169 start-page: 442 year: 2017 ident: 10.1124/dmd.118.083402_bib76 article-title: Host-microbe co-metabolism dictates cancer drug efficacy in C. elegans publication-title: Cell doi: 10.1016/j.cell.2017.03.040 – volume: 7 start-page: 35 year: 1997 ident: 10.1124/dmd.118.083402_bib60 article-title: Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil publication-title: Pharmacogenetics doi: 10.1097/00008571-199702000-00005 – volume: 4 start-page: 46 year: 2018 ident: 10.1124/dmd.118.083402_bib5 article-title: Nonsteroidal anti-inflammatory drug-induced leaky gut modeled using polarized monolayers of primary human intestinal epithelial cells publication-title: ACS Infect Dis doi: 10.1021/acsinfecdis.7b00139 – volume: 9 start-page: eaal4069 year: 2017 ident: 10.1124/dmd.118.083402_bib30 article-title: The effects of micronutrient deficiencies on bacterial species from the human gut microbiota publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aal4069 – volume: 39 start-page: 1747 year: 2011 ident: 10.1124/dmd.118.083402_bib15 article-title: Investigations of hydrazine cleavage of eltrombopag in humans publication-title: Drug Metab Dispos doi: 10.1124/dmd.111.040188 – volume: 113 start-page: 13887 year: 2016 ident: 10.1124/dmd.118.083402_bib66 article-title: Genome-wide screen identifies host colonization determinants in a bacterial gut symbiont publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1610856113 – volume: 97 start-page: 3473 year: 2000 ident: 10.1124/dmd.118.083402_bib31 article-title: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.97.7.3473 – volume: 17 start-page: 685 year: 1987 ident: 10.1124/dmd.118.083402_bib84 article-title: The reduction of sulphinpyrazone and sulindac by intestinal bacteria publication-title: Xenobiotica doi: 10.3109/00498258709043976 – volume: 464 start-page: 59 year: 2010 ident: 10.1124/dmd.118.083402_bib68 article-title: A human gut microbial gene catalogue established by metagenomic sequencing publication-title: Nature doi: 10.1038/nature08821 – year: 2018 ident: 10.1124/dmd.118.083402_bib6 article-title: Illuminating the microbiome’s dark matter: a functional genomic toolkit for the study of human gut actinobacteria publication-title: bioRxiv – volume: 43 start-page: 1572 year: 2015 ident: 10.1124/dmd.118.083402_bib77 article-title: RNA-Seq quantification of hepatic drug processing genes in germ-free mice publication-title: Drug Metab Dispos doi: 10.1124/dmd.115.063545 – volume: 31 start-page: 3368 year: 2015 ident: 10.1124/dmd.118.083402_bib61 article-title: MetaQuery: a web server for rapid annotation and quantitative analysis of specific genes in the human gut microbiome publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv382 – volume: 526 start-page: 343 year: 2015 ident: 10.1124/dmd.118.083402_bib71 article-title: Pharmacogenomics in the clinic publication-title: Nature doi: 10.1038/nature15817 – volume: 31 start-page: 246 year: 2010 ident: 10.1124/dmd.118.083402_bib57 article-title: Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2010.03.003 – volume: 190 start-page: 5981 year: 2008 ident: 10.1124/dmd.118.083402_bib86 article-title: Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli publication-title: J Bacteriol doi: 10.1128/JB.01982-07 – volume: 7 start-page: 68 year: 2016 ident: 10.1124/dmd.118.083402_bib52 article-title: Antibiotic-treated versus germ-free rodents for microbiota transplantation studies publication-title: Gut Microbes doi: 10.1080/19490976.2015.1127463 – volume: 46 start-page: e5 year: 2018 ident: 10.1124/dmd.118.083402_bib16 article-title: panX: pan-genome analysis and exploration publication-title: Nucleic Acids Res doi: 10.1093/nar/gkx977 – volume: 91 start-page: 321 year: 2012 ident: 10.1124/dmd.118.083402_bib13 article-title: cytochrome P450 2D6 CYP2D6) genotype publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2011.287 – volume: 84 start-page: 248 year: 2008 ident: 10.1124/dmd.118.083402_bib29 article-title: Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2008.1 – volume: 5 start-page: 87 year: 2017 ident: 10.1124/dmd.118.083402_bib83 article-title: Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning publication-title: Microbiome doi: 10.1186/s40168-017-0306-2 – volume: 21 start-page: 821 year: 1972 ident: 10.1124/dmd.118.083402_bib89 article-title: Studies of the metabolism of methotrexate by intestinal flora. I. Identification and study of biological properties of the metabolite 4-amino-4-deoxy-N 10 -methylpteroic acid publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(72)90125-6 – volume: 39 start-page: 3564 year: 1979 ident: 10.1124/dmd.118.083402_bib67 article-title: Metabolic conversion of indicine N-oxide to indicine in rabbits and humans publication-title: Cancer Res – volume: 14 start-page: 273 year: 2016 ident: 10.1124/dmd.118.083402_bib82 article-title: The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro.2016.17 – volume: 46 start-page: 27 year: 2001 ident: 10.1124/dmd.118.083402_bib2 article-title: Caco-2 monolayers in experimental and theoretical predictions of drug transport publication-title: Adv Drug Deliv Rev doi: 10.1016/S0169-409X(00)00128-9 – volume: 22 start-page: 838 year: 2012 ident: 10.1124/dmd.118.083402_bib97 article-title: Development of fecal microbial enzyme mix for mutagenicity assay of natural products publication-title: J Microbiol Biotechnol doi: 10.4014/jmb.1112.12028 – volume: 229 start-page: 194 year: 1937 ident: 10.1124/dmd.118.083402_bib21 article-title: Is p-aminobenzenesulphonamide the active agent in prontosil therapy? publication-title: Lancet doi: 10.1016/S0140-6736(00)97447-6 – volume: 42 start-page: 428 year: 1978 ident: 10.1124/dmd.118.083402_bib58 article-title: Gnotobiotic pigs-derivation and rearing publication-title: Can J Comp Med – volume: 13 start-page: 262 year: 1999 ident: 10.1124/dmd.118.083402_bib51 article-title: Determination of unbound drug concentration and protein-drug binding fraction in plasma publication-title: Biomed Chromatogr doi: 10.1002/(SICI)1099-0801(199906)13:4<262::AID-BMC832>3.0.CO;2-2 – volume: 4 start-page: 193 year: 2013 ident: 10.1124/dmd.118.083402_bib100 article-title: A pig model of the human gastrointestinal tract publication-title: Gut Microbes doi: 10.4161/gmic.23867 – volume: 227 start-page: 157 year: 2001 ident: 10.1124/dmd.118.083402_bib3 article-title: Colonic metabolism of ranitidine: implications for its delivery and absorption publication-title: Int J Pharm doi: 10.1016/S0378-5173(01)00794-3 – volume: 7 start-page: e33953 year: 2018 ident: 10.1124/dmd.118.083402_bib42 article-title: Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins publication-title: eLife doi: 10.7554/eLife.33953 – volume: 237 start-page: 23 year: 2002 ident: 10.1124/dmd.118.083402_bib4 article-title: Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora publication-title: Int J Pharm doi: 10.1016/S0378-5173(02)00018-2 – volume: 42 start-page: 1508 year: 2014 ident: 10.1124/dmd.118.083402_bib99 article-title: Gut microbiota-mediated drug interactions between lovastatin and antibiotics publication-title: Drug Metab Dispos doi: 10.1124/dmd.114.058354 – volume: 67 start-page: 282 year: 2018 ident: 10.1124/dmd.118.083402_bib98 article-title: The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat publication-title: Hepatology doi: 10.1002/hep.29327 – volume: 194 start-page: 1983 year: 2015 ident: 10.1124/dmd.118.083402_bib19 article-title: TLR signaling modulates side effects of anticancer therapy in the small intestine publication-title: J Immunol doi: 10.4049/jimmunol.1402481 – volume: 5 start-page: 12689 year: 2015 ident: 10.1124/dmd.118.083402_bib34 article-title: Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles publication-title: Sci Rep doi: 10.1038/srep12689 – volume: 40 start-page: 1130 year: 2012 ident: 10.1124/dmd.118.083402_bib49 article-title: Metabolic switching of BILR 355 in the presence of ritonavir. II. Uncovering novel contributions by gut bacteria and aldehyde oxidase publication-title: Drug Metab Dispos doi: 10.1124/dmd.111.044362 – volume: 111 start-page: 1661 year: 2014 ident: 10.1124/dmd.118.083402_bib95 article-title: Gnotobiotics publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1324049111 – volume: 555 start-page: 623 year: 2018 ident: 10.1124/dmd.118.083402_bib54 article-title: Extensive impact of non-antibiotic drugs on human gut bacteria publication-title: Nature doi: 10.1038/nature25979 – volume: 330 start-page: 831 year: 2010 ident: 10.1124/dmd.118.083402_bib91 article-title: Alleviating cancer drug toxicity by inhibiting a bacterial enzyme publication-title: Science doi: 10.1126/science.1191175 – volume: 7 start-page: 11535 year: 2016 ident: 10.1124/dmd.118.083402_bib78 article-title: A microfluidics-based in vitro model of the gastrointestinal human-microbe interface publication-title: Nat Commun doi: 10.1038/ncomms11535 – volume: 37 start-page: 1611 year: 2009 ident: 10.1124/dmd.118.083402_bib9 article-title: Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity publication-title: Drug Metab Dispos doi: 10.1124/dmd.109.027565 – volume: 17 start-page: 222 year: 2012 ident: 10.1124/dmd.118.083402_bib46 article-title: Automation of cell-based drug absorption assays in 96-well format using permeable support systems publication-title: J Lab Autom doi: 10.1177/2211068211428190 – volume: 6 start-page: 1415 year: 2012 ident: 10.1124/dmd.118.083402_bib101 article-title: The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates publication-title: ISME J doi: 10.1038/ismej.2011.212 – volume: 305 start-page: 789 year: 1981 ident: 10.1124/dmd.118.083402_bib50 article-title: Inactivation of digoxin by the gut flora: reversal by antibiotic therapy publication-title: N Engl J Med doi: 10.1056/NEJM198110013051403 – volume: 169 start-page: 431 year: 2017 ident: 10.1124/dmd.118.083402_bib22 article-title: C. elegans response to cancer chemotherapeutics publication-title: Cell doi: 10.1016/j.cell.2017.03.046 – volume: 287 start-page: 791 year: 1998 ident: 10.1124/dmd.118.083402_bib62 article-title: A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs publication-title: J Pharmacol Exp Ther doi: 10.1016/S0022-3565(24)37858-9 – volume: 15 start-page: 397 year: 2018 ident: 10.1124/dmd.118.083402_bib88 article-title: The gut-liver axis and the intersection with the microbiome publication-title: Nat Rev Gastroenterol Hepatol doi: 10.1038/s41575-018-0011-z – volume: 25 start-page: S121 issue: Suppl 2 year: 1997 ident: 10.1124/dmd.118.083402_bib69 article-title: Clostridium leptum, a nitroreductase-producing bacterium isolated from the human intestinal tract publication-title: Clin Infect Dis doi: 10.1086/516204 – volume: 4 start-page: 477 year: 1974 ident: 10.1124/dmd.118.083402_bib81 article-title: Metabolism of N-acylated and O-alkylated drugs by the intestinal microflora during anaerobic incubation in vitro publication-title: Xenobiotica doi: 10.3109/00498257409052100 – volume: 152 start-page: 39 year: 2013 ident: 10.1124/dmd.118.083402_bib55 article-title: Xenobiotics shape the physiology and gene expression of the active human gut microbiome publication-title: Cell doi: 10.1016/j.cell.2012.10.052 – volume: 16 start-page: 625 year: 2013 ident: 10.1124/dmd.118.083402_bib1 article-title: Bringing the gut microbiota into focus through microbial culture: recent progress and future perspective publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2013.09.008 – volume: 1 start-page: 16203 year: 2016 ident: 10.1124/dmd.118.083402_bib44 article-title: Culture of previously uncultured members of the human gut microbiota by culturomics publication-title: Nat Microbiol doi: 10.1038/nmicrobiol.2016.203 – volume: 25 start-page: 422 year: 1973 ident: 10.1124/dmd.118.083402_bib8 article-title: The demethylation of methamphetamine by intestinal microflora publication-title: J Pharm Pharmacol doi: 10.1111/j.2042-7158.1973.tb10043.x – volume: 84 start-page: 516 year: 1995 ident: 10.1124/dmd.118.083402_bib92 article-title: Metabolism of omeprazole by gut flora in rats publication-title: J Pharm Sci doi: 10.1002/jps.2600840425 – volume: 14 start-page: 1004 year: 1997 ident: 10.1124/dmd.118.083402_bib75 article-title: Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms publication-title: Pharm Res doi: 10.1023/A:1012141025938 – volume: 102 start-page: 581 year: 1992 ident: 10.1124/dmd.118.083402_bib65 article-title: Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2 publication-title: J Cell Sci doi: 10.1242/jcs.102.3.581 – volume: 419 start-page: 238 year: 2012 ident: 10.1124/dmd.118.083402_bib59 article-title: Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2012.01.155 |
| SSID | ssj0014439 |
| Score | 2.4280162 |
| SecondaryResourceType | review_article |
| Snippet | With a paradigm shift occurring in health care toward personalized and precision medicine, understanding the numerous environmental factors that impact drug... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1588 |
| SubjectTerms | Animals Drug development Drug Discovery - methods Drug metabolism Environmental factors Environmental impact Excretion Gastrointestinal Microbiome - physiology Humans In vivo methods and tests Inactivation, Metabolic - physiology Medicine Metabolism Microbiomes Pharmaceutical Preparations - metabolism Pharmacology Precision medicine Special Section – New Models in Drug Metabolism and Transport |
| Title | How to Determine the Role of the Microbiome in Drug Disposition |
| URI | https://dx.doi.org/10.1124/dmd.118.083402 https://www.ncbi.nlm.nih.gov/pubmed/30111623 https://www.proquest.com/docview/2164529827 https://www.proquest.com/docview/2089290975 https://pubmed.ncbi.nlm.nih.gov/PMC7333656 |
| Volume | 46 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKkNBeEHcKAxkJjZdlxImTOE8IRtEEKiqok_YWObEzKrVO1aYP8D_5PxxfcmlZJdhLZSVO3Ob7enzOybkg9DrJYU-gYejBbhN7VPLYYyVlni9IGOWgT-TG3zH-Gp9f0M-X0eVg8LsXtbSp89Pi17V5JTdBFY4BrjpL9j-QbW8KB2AM-MInIAyf_4Sx6QdXgcywIS3SaJHfXbygHo9nts7SwpQG-bjaXOlym02gVl8xNecWsgZOzJu-GWJnqvGlr0GZtG73lQDZMDrt3r9zBXKUK1Utq83chu9thf9OZnJpGaI9AWuQRuP26g-6q5jrb60UX2gTvrm5c0oQ5rLzGhpNu6wYtRV-OunqcdvyUqN-H4Npl3LW91T6qe-lUeQqZjs5HcCCvunC2wpy58t0hCU9sUwi2zvQbfGgwkXXbx8BBczFQsCQnYJ2Sk06eN3j0nJhyKTlIoltqvROwe7J-CwJwxAU5VvodgDWi26s8eVb93KL0tBaZe53uVqisPjb7aUP0Z1mnX1q099m0W50b09dmt5Dd52dg99b0t5HA6keoGMHzM8T3AfhBB_jPmQP0TtgNq4r3DIbA5uxZjauSjPumI1nCmv24h6zH6GLT6Pp2bnnWn14BezUtRfJIKE8pMIvKC0kbCyh4FEZxAk8BypC4XNQJhMio1KIhJV5IYpUkqIghAsa8fAxOlCVkk8RDlmuGy9JWsKt0oLwQNvoQUwYZwkj5RB5zZPMClcHX7djmWfGHg5oBiDAgGUWhCF6085f2gowe2eSBpjM6a9WL82AX3uvOWoQzJxkWWcB0eEGKQuSIXrVnga5r1_mcSWrDczxGVg2fppEQ_TEAt5-vYY0Q5RsUaGdoGvKb59Rsx-mtrxj7rMbX_kcHXYC4Qgd1KuNfAF6e52_NP-CPwFd73c |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=How+to+Determine+the+Role+of+the+Microbiome+in+Drug+Disposition&rft.jtitle=Drug+metabolism+and+disposition&rft.au=Bisanz%2C+Jordan+E.&rft.au=Spanogiannopoulos%2C+Peter&rft.au=Pieper%2C+Lindsey+M.&rft.au=Bustion%2C+Annamarie+E.&rft.date=2018-11-01&rft.pub=The+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=0090-9556&rft.eissn=1521-009X&rft.volume=46&rft.issue=11&rft.spage=1588&rft.epage=1595&rft_id=info:doi/10.1124%2Fdmd.118.083402&rft_id=info%3Apmid%2F30111623&rft.externalDocID=PMC7333656 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0090-9556&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0090-9556&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0090-9556&client=summon |