Lipopolysaccharide promotes lung fibroblast proliferation through autophagy inhibition via activation of the PI3K-Akt-mTOR pathway - Xie, Tingting; Xu, Qiaoyi; Wan, Hanxi; Xing, Shunpeng; Shang, Chen; Gao, Yuan; He, Zhengyu (Laboratory investigation, 2019)
Keywords: 1-Phosphatidylinositol 3-kinase; 101/28; 13; 13/106; 631/80/39/2346; 692/420/256/1980; 82; 82/1; 82/29; Activation; AKT protein; Animals; Autophagy; Autophagy - drug effects; Cell Proliferation - drug effects; Cells, Cultured; Chromones - pharmacology; Fibroblasts; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibrosis; Hydroxychloroquine; Hydroxychloroquine - pharmacology; Inhibition; Inhibitors; Kinases; Laboratory Medicine; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Lung - cytology; Lung diseases; Medicine; Medicine & Public Health; Mice, Inbred C57BL; Morpholines - pharmacology; Pathology; Phagocytosis; Phagosomes; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Proto-Oncogene Proteins c-akt - metabolism; Pulmonary fibrosis; Rapamycin; Respiratory distress syndrome; Signal transduction; Signal Transduction - drug effects; Sirolimus - pharmacology; TOR protein; TOR Serine-Threonine Kinases - metabolism