Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels

Gut microbiota is a potent biological modulator of many physiological and pathological states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI RAS), emerges as a potential mediator of microbiota-related effects. The RAS is involved in cardiovascular system homeostasi...

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Published inAmerican journal of physiology: Gastrointestinal and liver physiology Vol. 321; no. 4; pp. G355 - G366
Main Authors Jaworska, Kinga, Koper, Mateusz, Ufnal, Marcin
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.10.2021
SeriesMicrobiome-Based Therapeutics and Their Physiological Effects
Subjects
Aging
Angiotensin
Carcinogenesis
Cardiovascular system
Digestive system
Electrolyte balance
Endocrine system
Gastrointestinal diseases
Gastrointestinal tract
Gut microbiota
Homeostasis
Intestinal absorption
Intestinal microflora
Intestine
Microbiomes
Microbiota
Pharmacodynamics
Renin
Review
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Abstract Gut microbiota is a potent biological modulator of many physiological and pathological states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI RAS), emerges as a potential mediator of microbiota-related effects. The RAS is involved in cardiovascular system homeostasis, water-electrolyte balance, intestinal absorption, glycemic control, inflammation, carcinogenesis, and aging-related processes. Ample evidence suggests a bidirectional interaction between the microbiome and RAS. On the one hand, gut bacteria and their metabolites may modulate GI and systemic RAS. On the other hand, changes in the intestinal habitat caused by alterations in RAS may shape microbiota metabolic activity and composition. Notably, the pharmacodynamic effects of the RAS-targeted therapies may be in part mediated by the intestinal RAS and changes in the microbiome. This review summarizes studies on gut microbiota and RAS physiology. Expanding the research on this topic may lay the foundation for new therapeutic paradigms in gastrointestinal diseases and multiple systemic disorders.
AbstractList Gut microbiota is a potent biological modulator of many physiological and pathological states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI RAS), emerges as a potential mediator of microbiota-related effects. The RAS is involved in cardiovascular system homeostasis, water-electrolyte balance, intestinal absorption, glycemic control, inflammation, carcinogenesis, and aging-related processes. Ample evidence suggests a bidirectional interaction between the microbiome and RAS. On the one hand, gut bacteria and their metabolites may modulate GI and systemic RAS. On the other hand, changes in the intestinal habitat caused by alterations in RAS may shape microbiota metabolic activity and composition. Notably, the pharmacodynamic effects of the RAS-targeted therapies may be in part mediated by the intestinal RAS and changes in the microbiome. This review summarizes studies on gut microbiota and RAS physiology. Expanding the research on this topic may lay the foundation for new therapeutic paradigms in gastrointestinal diseases and multiple systemic disorders.
Gut microbiota is a potent biological modulator of many physiological and pathological states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI RAS), emerges as a potential mediator of microbiota-related effects. The RAS is involved in cardiovascular system homeostasis, water-electrolyte balance, intestinal absorption, glycemic control, inflammation, carcinogenesis, and aging-related processes. Ample evidence suggests a bidirectional interaction between the microbiome and RAS. On the one hand, gut bacteria and their metabolites may modulate GI and systemic RAS. On the other hand, changes in the intestinal habitat caused by alterations in RAS may shape microbiota metabolic activity and composition. Notably, the pharmacodynamic effects of the RAS-targeted therapies may be in part mediated by the intestinal RAS and changes in the microbiome. This review summarizes studies on gut microbiota and RAS physiology. Expanding the research on this topic may lay the foundation for new therapeutic paradigms in gastrointestinal diseases and multiple systemic disorders.Gut microbiota is a potent biological modulator of many physiological and pathological states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI RAS), emerges as a potential mediator of microbiota-related effects. The RAS is involved in cardiovascular system homeostasis, water-electrolyte balance, intestinal absorption, glycemic control, inflammation, carcinogenesis, and aging-related processes. Ample evidence suggests a bidirectional interaction between the microbiome and RAS. On the one hand, gut bacteria and their metabolites may modulate GI and systemic RAS. On the other hand, changes in the intestinal habitat caused by alterations in RAS may shape microbiota metabolic activity and composition. Notably, the pharmacodynamic effects of the RAS-targeted therapies may be in part mediated by the intestinal RAS and changes in the microbiome. This review summarizes studies on gut microbiota and RAS physiology. Expanding the research on this topic may lay the foundation for new therapeutic paradigms in gastrointestinal diseases and multiple systemic disorders.
Author Koper, Mateusz
Jaworska, Kinga
Ufnal, Marcin
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  givenname: Marcin
  orcidid: 0000-0003-0088-8284
  surname: Ufnal
  fullname: Ufnal, Marcin
  organization: Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland
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Cites_doi 10.1161/HYPERTENSIONAHA.115.05315
10.1073/pnas.0903958106
10.1056/NEJMoa043335
10.1152/physrev.1977.57.2.313
10.1677/joe.0.0860035
10.1152/ajpgi.2001.281.5.G1309
10.1073/pnas.1922189117
10.4103/cmi.cmi_80_20
10.1111/j.1750-3841.2007.00643.x
10.1186/s12885-016-2093-8
10.1016/j.chom.2007.06.010
10.1126/sciimmunol.abc3582
10.1016/j.cjca.2014.09.010
10.1016/j.cdtm.2019.09.001
10.1136/gutjnl-2011-300046
10.1161/HYPERTENSIONAHA.119.13155
10.1016/j.bbr.2018.07.001
10.1056/NEJM199109263251306
10.1002/path.1570
10.1177/1099800420942942
10.1016/j.chom.2012.07.004
10.20944/preprints202003.0161.v1
10.1053/j.gastro.2012.11.005
10.3168/jds.S0022-0302(95)76689-9
10.1161/CIRCULATIONAHA.116.024545
10.1113/jphysiol.2007.138578
10.1038/s41591-019-0504-5
10.1111/j.1748-1716.2010.02165.x
10.1016/j.jhep.2020.05.047
10.1007/s00125-018-4550-1
10.7554/eLife.57028
10.3168/jds.S0022-0302(00)74872-7
10.1124/jpet.102.044099
10.1080/07315724.2005.10719473
10.1111/j.1748-1716.2006.01600.x
10.1016/j.peptides.2015.11.003
10.26402/jpp.2018.4.07
10.1016/j.gene.2007.05.010
10.1023/a:1018946228432
10.1161/HYPERTENSIONAHA.120.15360
10.1016/j.chom.2017.03.002
10.1126/scitranslmed.aaf9655
10.3164/jcbn.10-114
10.1152/ajpcell.00135.2009
10.1172/JCI33293
10.1038/nmicrobiol.2017.8
10.3389/fphys.2017.00276
10.3785/j.issn.1008-9292.2020.02.02
10.1152/ajpgi.00264.2009
10.1016/j.tem.2005.07.009
10.1093/gerona/glz222
10.1152/ajpgi.00189.2013
10.1111/jgh.12112
10.1371/journal.pone.0119462
10.1007/s00418-013-1086-9
10.1152/physrev.00036.2005
10.3390/biology10040348
10.1056/NEJMoa2002032
10.1152/ajpgi.00053.2019
10.1152/ajpgi.1989.257.4.G504
10.1093/cid/ciaa709
10.1038/s41564-020-0688-y
10.1210/en.2003-0150
10.1038/s41401-019-0326-5
10.1097/HJH.0000000000002864
10.1146/annurev.pharmtox.010909.105610
10.1111/nmo.13623
10.1152/ajpregu.1998.275.2.R515
10.1039/d0fo01119c
10.1113/jphysiol.1988.sp017015
10.1051/lait:2006023
10.1111/j.1748-1716.2007.01826.x
10.1007/s003950170073
10.1167/tvst.9.13.20
10.1016/j.cub.2016.04.016
10.1177/1535370219900898
10.1161/CIRCRESAHA.120.317015
10.1161/CIRCRESAHA.121.318902
10.1152/ajpendo.00562.2011
10.2337/db11-1019
10.1053/j.gastro.2020.07.067
10.1016/j.omtm.2019.06.007
10.1172/jci110135
10.1038/ni.3780
10.1002/ddr.21656
10.1161/01.atv.0000021412.56621.a2
10.1038/nature11450
10.1016/j.coph.2014.08.007
10.1136/gut.2003.036343
10.1007/s00432-004-0582-7
10.1016/j.mcna.2016.08.017
10.1007/s12325-020-01455-2
10.1016/j.phrs.2020.105273
10.1097/HJH.0000000000001378
10.18632/oncotarget.24330
10.1007/s10620-018-4999-2
10.26402/jpp.2019.2.03
10.1152/physrev.00038.2017
10.9734/BJMMR/2017/30329
10.1111/j.1440-1746.2006.04797.x
10.3390/nu11122908
10.1016/S0140-6736(17)30182-4
10.1038/nature11228
10.1152/ajpgi.1985.249.1.G3
10.1016/j.ijfoodmicro.2013.09.002
10.7554/eLife.27014
10.3389/fmicb.2013.00030
10.1371/journal.pone.0248730
10.2174/092986712803413953
10.1152/ajpcell.00287.2006
10.1371/journal.pone.0184274
10.1073/pnas.1518189113
10.1111/j.1365-2796.2008.01981.x
10.5772/intechopen.94325
10.1371/journal.pone.0034026
10.1016/j.npep.2020.102056
10.1084/jem.20181939
10.1007/s12029-020-00531-8
10.3168/jds.S0022-0302(95)76745-5
10.1161/CIRCRESAHA.117.309715
10.1371/journal.pone.0189310
10.1007/s40520-013-0148-0
10.1073/pnas.1000097107
10.1016/j.bbrc.2015.03.035
10.1016/j.chom.2016.01.008
10.1111/hepr.13281
10.1016/s0008-6363(99)00110-8
10.1038/ncomms7528
10.1136/jitc-2020-001020
10.1177/002215540205000215
10.1073/pnas.1215927110
10.1161/JAHA.116.003698
10.1016/j.immuni.2018.12.015
10.1007/s10620-006-9124-2
10.1681/ASN.V102245
10.1111/j.1365-2036.2011.04971.x
10.1172/JCI112566
10.1039/c8fo00081f
10.1016/j.yexmp.2019.104350
10.1038/s41586-020-2474-7
10.1007/s00424-019-02322-y
10.1038/nrmicro3344
10.1097/00005344-199219006-00013
10.1016/j.arr.2020.101123
10.1093/ajcn/77.2.326
10.1038/srep27552
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B18
B19
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B146
B143
B144
B141
B142
B140
References_xml – ident: B4
  doi: 10.1161/HYPERTENSIONAHA.115.05315
– ident: B88
  doi: 10.1073/pnas.0903958106
– ident: B92
  doi: 10.1056/NEJMoa043335
– ident: B5
  doi: 10.1152/physrev.1977.57.2.313
– ident: B60
  doi: 10.1677/joe.0.0860035
– ident: B96
  doi: 10.1152/ajpgi.2001.281.5.G1309
– ident: B90
  doi: 10.1073/pnas.1922189117
– ident: B136
  doi: 10.4103/cmi.cmi_80_20
– ident: B47
  doi: 10.1111/j.1750-3841.2007.00643.x
– ident: B112
  doi: 10.1186/s12885-016-2093-8
– ident: B99
  doi: 10.1016/j.chom.2007.06.010
– ident: B137
  doi: 10.1126/sciimmunol.abc3582
– ident: B53
  doi: 10.1016/j.cjca.2014.09.010
– ident: B104
  doi: 10.1016/j.cdtm.2019.09.001
– ident: B22
  doi: 10.1136/gutjnl-2011-300046
– ident: B54
  doi: 10.1161/HYPERTENSIONAHA.119.13155
– ident: B55
  doi: 10.1016/j.bbr.2018.07.001
– ident: B80
  doi: 10.1056/NEJM199109263251306
– ident: B24
  doi: 10.1002/path.1570
– ident: B77
  doi: 10.1177/1099800420942942
– ident: B100
  doi: 10.1016/j.chom.2012.07.004
– ident: B121
  doi: 10.20944/preprints202003.0161.v1
– ident: B117
  doi: 10.1053/j.gastro.2012.11.005
– ident: B44
  doi: 10.3168/jds.S0022-0302(95)76689-9
– ident: B50
  doi: 10.1161/CIRCULATIONAHA.116.024545
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  doi: 10.1113/jphysiol.2007.138578
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  doi: 10.1038/s41591-019-0504-5
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  doi: 10.1111/j.1748-1716.2010.02165.x
– ident: B94
  doi: 10.1016/j.jhep.2020.05.047
– ident: B69
  doi: 10.1007/s00125-018-4550-1
– ident: B32
  doi: 10.7554/eLife.57028
– ident: B37
  doi: 10.3168/jds.S0022-0302(00)74872-7
– ident: B93
  doi: 10.1124/jpet.102.044099
– ident: B39
  doi: 10.1080/07315724.2005.10719473
– ident: B25
  doi: 10.1111/j.1748-1716.2006.01600.x
– ident: B41
  doi: 10.1016/j.peptides.2015.11.003
– ident: B84
  doi: 10.26402/jpp.2018.4.07
– ident: B40
  doi: 10.1016/j.gene.2007.05.010
– ident: B64
  doi: 10.1023/a:1018946228432
– ident: B122
  doi: 10.1161/HYPERTENSIONAHA.120.15360
– ident: B127
  doi: 10.1016/j.chom.2017.03.002
– ident: B91
  doi: 10.1126/scitranslmed.aaf9655
– ident: B110
  doi: 10.3164/jcbn.10-114
– ident: B76
  doi: 10.1152/ajpcell.00135.2009
– ident: B51
  doi: 10.1172/JCI33293
– ident: B101
  doi: 10.1038/nmicrobiol.2017.8
– ident: B119
  doi: 10.3389/fphys.2017.00276
– ident: B145
  doi: 10.3785/j.issn.1008-9292.2020.02.02
– ident: B86
  doi: 10.1152/ajpgi.00264.2009
– ident: B108
  doi: 10.1016/j.tem.2005.07.009
– ident: B134
  doi: 10.1093/gerona/glz222
– ident: B62
  doi: 10.1152/ajpgi.00189.2013
– ident: B113
  doi: 10.1111/jgh.12112
– ident: B105
  doi: 10.1371/journal.pone.0119462
– ident: B27
  doi: 10.1007/s00418-013-1086-9
– ident: B13
  doi: 10.1152/physrev.00036.2005
– ident: B71
  doi: 10.3390/biology10040348
– ident: B143
  doi: 10.1056/NEJMoa2002032
– ident: B87
  doi: 10.1152/ajpgi.00053.2019
– ident: B23
  doi: 10.1152/ajpgi.1989.257.4.G504
– ident: B146
  doi: 10.1093/cid/ciaa709
– ident: B135
  doi: 10.1038/s41564-020-0688-y
– ident: B9
  doi: 10.1210/en.2003-0150
– ident: B61
  doi: 10.1038/s41401-019-0326-5
– ident: B33
  doi: 10.1097/HJH.0000000000002864
– ident: B6
  doi: 10.1146/annurev.pharmtox.010909.105610
– ident: B30
  doi: 10.1111/nmo.13623
– ident: B59
  doi: 10.1152/ajpregu.1998.275.2.R515
– ident: B95
  doi: 10.1039/d0fo01119c
– ident: B74
  doi: 10.1113/jphysiol.1988.sp017015
– ident: B42
  doi: 10.1051/lait:2006023
– ident: B26
  doi: 10.1111/j.1748-1716.2007.01826.x
– ident: B21
  doi: 10.1007/s003950170073
– ident: B79
  doi: 10.1167/tvst.9.13.20
– ident: B130
  doi: 10.1016/j.cub.2016.04.016
– ident: B3
  doi: 10.1177/1535370219900898
– ident: B142
  doi: 10.1161/CIRCRESAHA.120.317015
– ident: B138
  doi: 10.1161/CIRCRESAHA.121.318902
– ident: B17
  doi: 10.1152/ajpendo.00562.2011
– ident: B70
  doi: 10.2337/db11-1019
– ident: B139
  doi: 10.1053/j.gastro.2020.07.067
– ident: B78
  doi: 10.1016/j.omtm.2019.06.007
– ident: B57
  doi: 10.1172/jci110135
– ident: B81
  doi: 10.1038/ni.3780
– ident: B140
  doi: 10.1002/ddr.21656
– ident: B10
  doi: 10.1161/01.atv.0000021412.56621.a2
– ident: B68
  doi: 10.1038/nature11450
– ident: B18
  doi: 10.1016/j.coph.2014.08.007
– ident: B20
  doi: 10.1136/gut.2003.036343
– ident: B115
  doi: 10.1007/s00432-004-0582-7
– ident: B7
  doi: 10.1016/j.mcna.2016.08.017
– ident: B15
  doi: 10.1007/s12325-020-01455-2
– ident: B31
  doi: 10.1016/j.phrs.2020.105273
– ident: B49
  doi: 10.1097/HJH.0000000000001378
– ident: B128
  doi: 10.18632/oncotarget.24330
– ident: B111
  doi: 10.1007/s10620-018-4999-2
– ident: B19
  doi: 10.26402/jpp.2019.2.03
– ident: B8
  doi: 10.1152/physrev.00038.2017
– ident: B66
  doi: 10.9734/BJMMR/2017/30329
– ident: B116
  doi: 10.1111/j.1440-1746.2006.04797.x
– ident: B48
  doi: 10.3390/nu11122908
– ident: B82
  doi: 10.1016/S0140-6736(17)30182-4
– ident: B65
  doi: 10.1038/nature11228
– ident: B58
  doi: 10.1152/ajpgi.1985.249.1.G3
– ident: B43
  doi: 10.1016/j.ijfoodmicro.2013.09.002
– ident: B133
  doi: 10.7554/eLife.27014
– ident: B46
  doi: 10.3389/fmicb.2013.00030
– ident: B123
  doi: 10.1371/journal.pone.0248730
– ident: B97
  doi: 10.2174/092986712803413953
– ident: B12
  doi: 10.1152/ajpcell.00287.2006
– ident: B126
  doi: 10.1371/journal.pone.0184274
– ident: B118
  doi: 10.1073/pnas.1518189113
– ident: B11
  doi: 10.1111/j.1365-2796.2008.01981.x
– ident: B144
  doi: 10.5772/intechopen.94325
– ident: B52
  doi: 10.1371/journal.pone.0034026
– ident: B67
  doi: 10.1016/j.npep.2020.102056
– ident: B106
  doi: 10.1084/jem.20181939
– ident: B103
  doi: 10.1007/s12029-020-00531-8
– ident: B45
  doi: 10.3168/jds.S0022-0302(95)76745-5
– ident: B1
  doi: 10.1161/CIRCRESAHA.117.309715
– ident: B56
  doi: 10.1371/journal.pone.0189310
– ident: B125
  doi: 10.1007/s40520-013-0148-0
– ident: B131
  doi: 10.1073/pnas.1000097107
– ident: B120
  doi: 10.1016/j.bbrc.2015.03.035
– ident: B129
  doi: 10.1016/j.chom.2016.01.008
– ident: B114
  doi: 10.1111/hepr.13281
– ident: B14
  doi: 10.1016/s0008-6363(99)00110-8
– ident: B102
  doi: 10.1038/ncomms7528
– ident: B124
  doi: 10.1136/jitc-2020-001020
– ident: B29
  doi: 10.1177/002215540205000215
– ident: B63
  doi: 10.1073/pnas.1215927110
– ident: B36
  doi: 10.1161/JAHA.116.003698
– ident: B89
  doi: 10.1016/j.immuni.2018.12.015
– ident: B85
  doi: 10.1007/s10620-006-9124-2
– ident: B109
  doi: 10.1681/ASN.V102245
– ident: B16
  doi: 10.1111/j.1365-2036.2011.04971.x
– ident: B28
  doi: 10.1172/JCI112566
– ident: B72
  doi: 10.1039/c8fo00081f
– ident: B98
  doi: 10.1016/j.yexmp.2019.104350
– ident: B34
  doi: 10.1038/s41586-020-2474-7
– ident: B2
  doi: 10.1007/s00424-019-02322-y
– ident: B107
  doi: 10.1038/nrmicro3344
– ident: B35
  doi: 10.1097/00005344-199219006-00013
– ident: B141
  doi: 10.1016/j.arr.2020.101123
– ident: B38
  doi: 10.1093/ajcn/77.2.326
– ident: B83
  doi: 10.1038/srep27552
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Snippet Gut microbiota is a potent biological modulator of many physiological and pathological states. The renin-angiotensin system (RAS), including the local...
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SubjectTerms Aging
Angiotensin
Carcinogenesis
Cardiovascular system
Digestive system
Electrolyte balance
Endocrine system
Gastrointestinal diseases
Gastrointestinal tract
Gut microbiota
Homeostasis
Intestinal absorption
Intestinal microflora
Intestine
Microbiomes
Microbiota
Pharmacodynamics
Renin
Review
Title Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels
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https://www.proquest.com/docview/2562515796
https://pubmed.ncbi.nlm.nih.gov/PMC8486428
Volume 321
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