Effect of glycyrrhizin on traumatic brain injury in rats and its mechanism

• Published in: Chinese journal of traumatology Vol. 17; no. 1; pp. 1 - 7
• Main Authors: Xiangjin, Gu, Jin, Xu, Banyou, Ma, Gong, Chen, Peiyuan, Gu, Dong, Wei, Weixing, Hu
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.02.2014; Department of Neurosurgery, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing 211100, China%Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Elsevier
• Subjects: Animals; Brain injuries; Brain Injuries - drug therapy; DNA结合活性; Glycyrrhizic acid; Glycyrrhizic Acid - pharmacology; Glycyrrhizic Acid - therapeutic use; HMGB1 protein; HMGB1 Protein - metabolism; Male; Neuroprotective agents; Neuroprotective Agents - therapeutic use; RAGE; Rats; Rats, Sprague-Dawley; SD大鼠; Toll样受体4; 创伤性脑损伤; 甘草甜素; 神经保护作用; 脑组织含水量; Glycyrrhizic acid; Neuroprotective agents; HMGB1 protein; Brain injuries

Objective： To investigate the neuropro- tective effects of glycyrrhizin （Gly） as well as its effect on expression of high-mobility group box 1 （HMGB1） in rats after traumatic brain injury （TBI）. Methods： Male Sprague-Dawley rats were randomly divided into three groups： sham group, TBI group, and TBI...