A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex

• Published in: PLoS pathogens Vol. 19; no. 11; p. e1011781
• Main Authors: Chen, Han, Lye, Ming F., Gorgulla, Christoph, Ficarro, Scott B., Cuny, Gregory D., Scott, David A., Wu, Fan, Rothlauf, Paul W., Wang, Xiaoou, Fernandez, Rosio, Pesola, Jean M., Draga, Sorin, Marto, Jarrod A., Hogle, James M., Arthanari, Haribabu, Coen, Donald M.
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 17.11.2023; Public Library of Science (PLoS)
• Subjects: Ablation; Acrylamide; Amides; Antibodies; Antiviral activity; Antiviral agents; Antiviral drugs; Assaying; Chromatography; Complications and side effects; Cytomegalovirus; Cytomegalovirus infections; Cytotoxicity; Dosage and administration; Drug development; Drug resistance; Drug therapy; Egress; Energy transfer; Fluorescence; Health aspects; Hearing loss; Herpes viruses; Immunoprecipitation; Infants (Newborn); Infections; Insects; Kinases; Localization; Mass spectrometry; Patient outcomes; Physiological aspects; Prevention; Proteins; Replication; Risk factors; Spectrometry; Substitutes; Viral proteins; United States

Human cytomegalovirus (HCMV) is an important pathogen for which new antiviral drugs are needed. HCMV, like other herpesviruses, encodes a nuclear egress complex (NEC) composed of two subunits, UL50 and UL53, whose interaction is crucial for viral replication. To explore whether small molecules can e...