The novel peptides ICRD and LCGEC screened from tuna roe show antioxidative activity via Keap1/Nrf2-ARE pathway regulation and gut microbiota modulation
•Two antioxidant peptides ICRD and LCGEC were screened and identified from tuna roe.•ICRD and LCGEC regulated Keap1/Nrf2-ARE pathway transcription in cell and mice.•LCGEC regulated gut microbiota structure and metabolism in mice. In this study, a high-throughput strategy combined with MALDI TOF/TOF-...
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| Published in | Food chemistry Vol. 327; p. 127094 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
15.10.2020
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| Subjects | |
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| Abstract | •Two antioxidant peptides ICRD and LCGEC were screened and identified from tuna roe.•ICRD and LCGEC regulated Keap1/Nrf2-ARE pathway transcription in cell and mice.•LCGEC regulated gut microbiota structure and metabolism in mice.
In this study, a high-throughput strategy combined with MALDI TOF/TOF-MS and Discovery Studio 2017 was developed to screen peptides with certain functions from hydrolysate. Two dominant peptides, Ile-Cys-Arg-Asp (ICRD) and Leu-Cys-Gly-Glu-Cys (LCGEC), were predicted to have antioxidant activity by Discovery Studio 2017. Then the activity in vitro of peptides had been confirmed via DPPH assay. Both two peptides decreased apoptosis induced by UVB treatment in HaCaT cells and altered Keap1/Nrf2-ARE pathway transcription. Furthermore, the antioxidant activity of LCGEC was achieved after 6-week treatment in mice via regulating the Keap1/Nrf2-ARE pathway, inhibiting the release of proinflammatory cytokines, increasing the abundance of 3-indolepropionic acid and short-chain fatty acids production in feces and modulating gut microbiota composition. This study provided two tuna roe peptides with in vitro and in vivo antioxidant activity. |
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| AbstractList | In this study, a high-throughput strategy combined with MALDI TOF/TOF-MS and Discovery Studio 2017 was developed to screen peptides with certain functions from hydrolysate. Two dominant peptides, Ile-Cys-Arg-Asp (ICRD) and Leu-Cys-Gly-Glu-Cys (LCGEC), were predicted to have antioxidant activity by Discovery Studio 2017. Then the activity in vitro of peptides had been confirmed via DPPH assay. Both two peptides decreased apoptosis induced by UVB treatment in HaCaT cells and altered Keap1/Nrf2-ARE pathway transcription. Furthermore, the antioxidant activity of LCGEC was achieved after 6-week treatment in mice via regulating the Keap1/Nrf2-ARE pathway, inhibiting the release of proinflammatory cytokines, increasing the abundance of 3-indolepropionic acid and short-chain fatty acids production in feces and modulating gut microbiota composition. This study provided two tuna roe peptides with in vitro and in vivo antioxidant activity. •Two antioxidant peptides ICRD and LCGEC were screened and identified from tuna roe.•ICRD and LCGEC regulated Keap1/Nrf2-ARE pathway transcription in cell and mice.•LCGEC regulated gut microbiota structure and metabolism in mice. In this study, a high-throughput strategy combined with MALDI TOF/TOF-MS and Discovery Studio 2017 was developed to screen peptides with certain functions from hydrolysate. Two dominant peptides, Ile-Cys-Arg-Asp (ICRD) and Leu-Cys-Gly-Glu-Cys (LCGEC), were predicted to have antioxidant activity by Discovery Studio 2017. Then the activity in vitro of peptides had been confirmed via DPPH assay. Both two peptides decreased apoptosis induced by UVB treatment in HaCaT cells and altered Keap1/Nrf2-ARE pathway transcription. Furthermore, the antioxidant activity of LCGEC was achieved after 6-week treatment in mice via regulating the Keap1/Nrf2-ARE pathway, inhibiting the release of proinflammatory cytokines, increasing the abundance of 3-indolepropionic acid and short-chain fatty acids production in feces and modulating gut microbiota composition. This study provided two tuna roe peptides with in vitro and in vivo antioxidant activity. In this study, a high-throughput strategy combined with MALDI TOF/TOF-MS and Discovery Studio 2017 was developed to screen peptides with certain functions from hydrolysate. Two dominant peptides, Ile-Cys-Arg-Asp (ICRD) and Leu-Cys-Gly-Glu-Cys (LCGEC), were predicted to have antioxidant activity by Discovery Studio 2017. Then the activity in vitro of peptides had been confirmed via DPPH assay. Both two peptides decreased apoptosis induced by UVB treatment in HaCaT cells and altered Keap1/Nrf2-ARE pathway transcription. Furthermore, the antioxidant activity of LCGEC was achieved after 6-week treatment in mice via regulating the Keap1/Nrf2-ARE pathway, inhibiting the release of proinflammatory cytokines, increasing the abundance of 3-indolepropionic acid and short-chain fatty acids production in feces and modulating gut microbiota composition. This study provided two tuna roe peptides with in vitro and in vivo antioxidant activity.In this study, a high-throughput strategy combined with MALDI TOF/TOF-MS and Discovery Studio 2017 was developed to screen peptides with certain functions from hydrolysate. Two dominant peptides, Ile-Cys-Arg-Asp (ICRD) and Leu-Cys-Gly-Glu-Cys (LCGEC), were predicted to have antioxidant activity by Discovery Studio 2017. Then the activity in vitro of peptides had been confirmed via DPPH assay. Both two peptides decreased apoptosis induced by UVB treatment in HaCaT cells and altered Keap1/Nrf2-ARE pathway transcription. Furthermore, the antioxidant activity of LCGEC was achieved after 6-week treatment in mice via regulating the Keap1/Nrf2-ARE pathway, inhibiting the release of proinflammatory cytokines, increasing the abundance of 3-indolepropionic acid and short-chain fatty acids production in feces and modulating gut microbiota composition. This study provided two tuna roe peptides with in vitro and in vivo antioxidant activity. |
| ArticleNumber | 127094 |
| Author | Li, Ye Su, Xiurong Jim Wang, Zaijie Zhou, Jun Han, Jiaojiao Tang, Shasha Huang, Zhongbai Lu, Chenyang Ming, Tinghong Wan, Haitao |
| Author_xml | – sequence: 1 givenname: Jiaojiao surname: Han fullname: Han, Jiaojiao organization: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China – sequence: 2 givenname: Zhongbai surname: Huang fullname: Huang, Zhongbai organization: School of Marine Science, Ningbo University, Ningbo, China – sequence: 3 givenname: Shasha surname: Tang fullname: Tang, Shasha organization: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China – sequence: 4 givenname: Chenyang surname: Lu fullname: Lu, Chenyang organization: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China – sequence: 5 givenname: Haitao surname: Wan fullname: Wan, Haitao organization: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China – sequence: 6 givenname: Jun surname: Zhou fullname: Zhou, Jun organization: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China – sequence: 7 givenname: Ye surname: Li fullname: Li, Ye organization: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China – sequence: 8 givenname: Tinghong surname: Ming fullname: Ming, Tinghong organization: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China – sequence: 9 givenname: Zaijie surname: Jim Wang fullname: Jim Wang, Zaijie organization: Department of Biopharmaceutical Sciences, University of Illinois, Chicago, USA – sequence: 10 givenname: Xiurong orcidid: 0000-0003-2336-191X surname: Su fullname: Su, Xiurong email: suxiurong_public@163.com organization: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32454270$$D View this record in MEDLINE/PubMed |
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| Keywords | PCoA Gut microbiota GSH-Px DPPH Tuna roe qRT-PCR SOD MTT Antioxidant Metabolism SCFA RDA IL-6 BHT LEfSe OTU TNF-α ROS BHA IPA Peptide High throughput strategty |
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| Snippet | •Two antioxidant peptides ICRD and LCGEC were screened and identified from tuna roe.•ICRD and LCGEC regulated Keap1/Nrf2-ARE pathway transcription in cell and... In this study, a high-throughput strategy combined with MALDI TOF/TOF-MS and Discovery Studio 2017 was developed to screen peptides with certain functions from... |
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| SubjectTerms | 2,2-diphenyl-1-picrylhydrazyl Antioxidant antioxidant activity apoptosis cytokines feces Gut microbiota High throughput strategty hydrolysates intestinal microorganisms matrix-assisted laser desorption-ionization mass spectrometry Metabolism mice Peptide short chain fatty acids tuna Tuna roe |
| Title | The novel peptides ICRD and LCGEC screened from tuna roe show antioxidative activity via Keap1/Nrf2-ARE pathway regulation and gut microbiota modulation |
| URI | https://dx.doi.org/10.1016/j.foodchem.2020.127094 https://www.ncbi.nlm.nih.gov/pubmed/32454270 https://www.proquest.com/docview/2407314075 https://www.proquest.com/docview/2985858151 |
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