Therapeutic Strategies to Reduce Burn Wound Conversion

Burn wound conversion refers to the phenomenon whereby superficial burns that appear to retain the ability to spontaneously heal, convert later into deeper wounds in need of excision. While no current treatment can definitively stop burn wound conversion, attempts to slow tissue damage remain unsati...

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Published inMedicina (Kaunas, Lithuania) Vol. 58; no. 7; p. 922
Main Authors Palackic, Alen, Jay, Jayson W., Duggan, Robert P., Branski, Ludwik K., Wolf, Steven E., Ansari, Naseem, El Ayadi, Amina
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 11.07.2022
MDPI
Subjects
Antibodies
Apoptosis
biologics
Burns
Cooling
Cytokines
First aid
Hyaluronic acid
Hypothermia
Inflammation
Ischemia
Medical research
Review
Wound healing
wounds and injuries
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Abstract Burn wound conversion refers to the phenomenon whereby superficial burns that appear to retain the ability to spontaneously heal, convert later into deeper wounds in need of excision. While no current treatment can definitively stop burn wound conversion, attempts to slow tissue damage remain unsatisfactory, justifying the need for new therapeutic interventions. To attenuate burn wound conversion, various studies have targeted at least one of the molecular mechanisms underlying burn wound conversion, including ischemia, inflammation, apoptosis, autophagy, generation of reactive oxygen species, hypothermia, and wound rehydration. However, therapeutic strategies that can target various mechanisms involved in burn wound conversion are still lacking. This review highlights the pathophysiology of burn wound conversion and focuses on recent studies that have turned to the novel use of biologics such as mesenchymal stem cells, biomaterials, and immune regulators to mitigate wound conversion. Future research should investigate mechanistic pathways, side effects, safety, and efficacy of these different treatments before translation into clinical studies.
AbstractList Burn wound conversion refers to the phenomenon whereby superficial burns that appear to retain the ability to spontaneously heal, convert later into deeper wounds in need of excision. While no current treatment can definitively stop burn wound conversion, attempts to slow tissue damage remain unsatisfactory, justifying the need for new therapeutic interventions. To attenuate burn wound conversion, various studies have targeted at least one of the molecular mechanisms underlying burn wound conversion, including ischemia, inflammation, apoptosis, autophagy, generation of reactive oxygen species, hypothermia, and wound rehydration. However, therapeutic strategies that can target various mechanisms involved in burn wound conversion are still lacking. This review highlights the pathophysiology of burn wound conversion and focuses on recent studies that have turned to the novel use of biologics such as mesenchymal stem cells, biomaterials, and immune regulators to mitigate wound conversion. Future research should investigate mechanistic pathways, side effects, safety, and efficacy of these different treatments before translation into clinical studies.
Author Duggan, Robert P.
El Ayadi, Amina
Branski, Ludwik K.
Palackic, Alen
Wolf, Steven E.
Ansari, Naseem
Jay, Jayson W.
AuthorAffiliation 1 Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA; alpalack@utmb.edu (A.P.); jwjay@utmb.edu (J.W.J.); rpduggan@utmb.edu (R.P.D.); lubransk@utmb.edu (L.K.B.); swolf@utmb.edu (S.E.W.)
3 Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA; nansari@utmb.edu
2 Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, A-8036 Graz, Austria
AuthorAffiliation_xml – name: 2 Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, A-8036 Graz, Austria
– name: 1 Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA; alpalack@utmb.edu (A.P.); jwjay@utmb.edu (J.W.J.); rpduggan@utmb.edu (R.P.D.); lubransk@utmb.edu (L.K.B.); swolf@utmb.edu (S.E.W.)
– name: 3 Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA; nansari@utmb.edu
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Snippet Burn wound conversion refers to the phenomenon whereby superficial burns that appear to retain the ability to spontaneously heal, convert later into deeper...
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SubjectTerms Antibodies
Apoptosis
biologics
Burns
Cooling
Cytokines
First aid
Hyaluronic acid
Hypothermia
Inflammation
Ischemia
Medical research
Review
Wound healing
wounds and injuries
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Title Therapeutic Strategies to Reduce Burn Wound Conversion
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https://pubmed.ncbi.nlm.nih.gov/PMC9315582
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