Synthetic zinc finger peptides: old and novel applications

• Published in: Biochemistry and cell biology Vol. 82; no. 4; pp. 428 - 436
• Main Authors: Corbi, Nicoletta, Libri, Valentina, Onori, Annalisa, Passananti, Claudio
• Format: Journal Article
• Language: English
• Published: Ottawa, Canada NRC Research Press 01.08.2004; Canadian Science Publishing NRC Research Press
• Subjects: Animals; Biochemistry; Biotechnology; Chromatin; Chromatin - chemistry; Deoxyribonucleic acid; DNA; DNA - chemistry; Gene therapy; Genetic Techniques; Genetic Therapy - methods; Humans; Models, Molecular; Peptides; Peptides - chemistry; Protein Engineering; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Transcription, Genetic; Zinc; Zinc Fingers

In the last decade, the efforts in clarifying the interaction between zinc finger proteins and DNA targets strongly stimulated the creativity of scientists in the field of protein engineering. In particular, the versatility and the modularity of zinc finger (ZF) motives make these domains optimal bu...