Interaction between gut microbiota and T cell immunity in colorectal cancer

• Published in: Autoimmunity reviews Vol. 24; no. 6; p. 103807
• Main Authors: Jing, Zhuang, Yinhang, Wu, Jian, Chu, Zhanbo, Qu, Xinyue, Wu, Shuwen, Han
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.05.2025
• Subjects: Allergy and Immunology; Animals; Colorectal cancer; Colorectal Neoplasms - immunology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - microbiology; Colorectal Neoplasms - therapy; Gastrointestinal Microbiome - immunology; Gut microbiota; Humans; Metabolites; T cell immunity; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tumor Microenvironment - immunology; Gut microbiota; intestinal epithelial cells; effector memory; inflammatory bowel diseases; Clostridiales strains; Colorectal cancer; inhibitors of differentiation 2; tertiary lymphoid structures; Lactobacillus rhamnosus GG; NLR family pyrin domain containing 3; bone marrow-derived dendritic cells; Sini Decoction; azoxymethane; tumor-associated macrophages; Abelmoschus manihot; box transcription factor 13; all-trans-retinoic acid; mesenteric lymph node; Metabolites; ketogenic diet; free fatty acid receptor 2; interleukin; metagenome-wide association study; hepatocellular carcinoma; N-3-oxododecanoyl-L-homoserine lactone; quorum sensing; Toll-like receptor 2; sex-determining region Y; Helicobacter Aciclocus; dextran sulfate sodium; T-helper 1 cells; traditional Chinese medicine; inflammatory bowel disease-associated CRCs; autoinducer-2; germinal center; tissue resident memory T; histone deacetylase; high-fatty-diet; regulatory T cells; Fusobacterium nucleatum; polymorphonuclear-myeloid-derived suppressor cells; T cell immunity; follicular helper T; IPA; Quxie Capsule; short-chain fatty acids; peroxisome proliferator-activated receptor gamma; transforming growth factor-β-activated kinase-1; Indole-3-Propionic Acid; TAM; HFD; IECs; TRM; MLN; atRA; Tfh; FFAR2; Th1; BM-DCs; QS; IL; DSS; QX; EM; HCC; AM; LGG; PPARγ; MGWAS; OdDHL; CRC; IBD-CRCs; PMN-MDSCs; TLR2; HDAC; TCM; SND; IBD; AI-2; TAK1; CC4; NLRP3; KD; SRY; Sox13; GC; TLSs; AOM; Tregs; Fn; Hhep; ID2; SCFAs

This review delves into the complex and multi-layered mechanisms that govern the interaction between gut microbiota and T cells in the context of colorectal cancer (CRC), revealing a novel “microbiota-immune regulatory landscape” within the tumor microenvironment. As CRC progresses, the gut microbio...