Cellular Networks Involved in the Influenza Virus Life Cycle

Influenza viruses cause epidemics and pandemics. Like all viruses, influenza viruses rely on the host cellular machinery to support their life cycle. Accordingly, identification of the host functions co-opted for viral replication is of interest to understand the mechanisms of the virus life cycle a...

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Published inCell host & microbe Vol. 7; no. 6; pp. 427 - 439
Main Authors Watanabe, Tokiko, Watanabe, Shinji, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published United States 25.06.2010
Subjects
Animals
Cell Line
Gene Knockdown Techniques - methods
Host-Pathogen Interactions
Humans
Orthomyxoviridae - growth & development
Orthomyxoviridae - pathogenicity
Orthomyxoviridae - physiology
Virus Replication
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Abstract Influenza viruses cause epidemics and pandemics. Like all viruses, influenza viruses rely on the host cellular machinery to support their life cycle. Accordingly, identification of the host functions co-opted for viral replication is of interest to understand the mechanisms of the virus life cycle and to find new targets for the development of antiviral compounds. Among the various approaches used to explore host factor involvement in the influenza virus replication cycle, perhaps the most powerful is RNAi-based genome-wide screening, which has shed new light on the search for host factors involved in virus replication. In this review, we examine the cellular genes identified to date as important for influenza virus replication in genome-wide screens, assess pathways that were repeatedly identified in these studies, and discuss how these pathways might be involved in the individual steps of influenza virus replication, ultimately leading to a comprehensive understanding of the virus life cycle.
AbstractList Influenza viruses cause epidemics and pandemics. Like all other viruses, influenza viruses rely on the host cellular machinery to support their life cycle. Accordingly, identification of host functions that participate in viral replication steps is of great interest to understand the mechanisms of the virus life cycle as well as to find new targets for the development of antiviral compounds. Multiple laboratories have used various approaches to explore host factors involvement in the influenza virus replication cycle. One of the most powerful approaches is an RNAi-based genome-wide screen, which has thrown new light on the search for host factors involved in virus replication. In this review, we examine the cellular genes identified to date as important for influenza virus replication in genome-wide screens, assess pathways that were repeatedly identified in these studies, and discuss how these pathways might be involved in the individual steps of influenza virus replication, ultimately leading to a comprehensive understanding of the virus life cycle.
Influenza viruses cause epidemics and pandemics. Like all viruses, influenza viruses rely on the host cellular machinery to support their life cycle. Accordingly, identification of the host functions co-opted for viral replication is of interest to understand the mechanisms of the virus life cycle and to find new targets for the development of antiviral compounds. Among the various approaches used to explore host factor involvement in the influenza virus replication cycle, perhaps the most powerful is RNAi-based genome-wide screening, which has shed new light on the search for host factors involved in virus replication. In this review, we examine the cellular genes identified to date as important for influenza virus replication in genome-wide screens, assess pathways that were repeatedly identified in these studies, and discuss how these pathways might be involved in the individual steps of influenza virus replication, ultimately leading to a comprehensive understanding of the virus life cycle.Influenza viruses cause epidemics and pandemics. Like all viruses, influenza viruses rely on the host cellular machinery to support their life cycle. Accordingly, identification of the host functions co-opted for viral replication is of interest to understand the mechanisms of the virus life cycle and to find new targets for the development of antiviral compounds. Among the various approaches used to explore host factor involvement in the influenza virus replication cycle, perhaps the most powerful is RNAi-based genome-wide screening, which has shed new light on the search for host factors involved in virus replication. In this review, we examine the cellular genes identified to date as important for influenza virus replication in genome-wide screens, assess pathways that were repeatedly identified in these studies, and discuss how these pathways might be involved in the individual steps of influenza virus replication, ultimately leading to a comprehensive understanding of the virus life cycle.
Influenza viruses cause epidemics and pandemics. Like all viruses, influenza viruses rely on the host cellular machinery to support their life cycle. Accordingly, identification of the host functions co-opted for viral replication is of interest to understand the mechanisms of the virus life cycle and to find new targets for the development of antiviral compounds. Among the various approaches used to explore host factor involvement in the influenza virus replication cycle, perhaps the most powerful is RNAi-based genome-wide screening, which has shed new light on the search for host factors involved in virus replication. In this review, we examine the cellular genes identified to date as important for influenza virus replication in genome-wide screens, assess pathways that were repeatedly identified in these studies, and discuss how these pathways might be involved in the individual steps of influenza virus replication, ultimately leading to a comprehensive understanding of the virus life cycle.
Author Watanabe, Shinji
Watanabe, Tokiko
Kawaoka, Yoshihiro
AuthorAffiliation 1 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA
2 ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan
4 International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
3 Division of Virology, Department of Microbiology and Immunology, University of Tokyo, Tokyo 108-8639, Japan
AuthorAffiliation_xml – name: 3 Division of Virology, Department of Microbiology and Immunology, University of Tokyo, Tokyo 108-8639, Japan
– name: 4 International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
– name: 2 ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan
– name: 1 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA
Author_xml – sequence: 1
  givenname: Tokiko
  surname: Watanabe
  fullname: Watanabe, Tokiko
– sequence: 2
  givenname: Shinji
  surname: Watanabe
  fullname: Watanabe, Shinji
– sequence: 3
  givenname: Yoshihiro
  surname: Kawaoka
  fullname: Kawaoka, Yoshihiro
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20542247$$D View this record in MEDLINE/PubMed
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Snippet Influenza viruses cause epidemics and pandemics. Like all viruses, influenza viruses rely on the host cellular machinery to support their life cycle....
Influenza viruses cause epidemics and pandemics. Like all other viruses, influenza viruses rely on the host cellular machinery to support their life cycle....
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pubmed
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StartPage 427
SubjectTerms Animals
Cell Line
Gene Knockdown Techniques - methods
Host-Pathogen Interactions
Humans
Orthomyxoviridae - growth & development
Orthomyxoviridae - pathogenicity
Orthomyxoviridae - physiology
Virus Replication
Title Cellular Networks Involved in the Influenza Virus Life Cycle
URI https://www.ncbi.nlm.nih.gov/pubmed/20542247
https://www.proquest.com/docview/733345030
https://pubmed.ncbi.nlm.nih.gov/PMC3167038
Volume 7
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