The Basophil Activation Test Is Not a Useful Screening Tool for Hymenoptera Venom-Related Anaphylaxis in Patients with Systemic Mastocytosis

• Published in: International archives of allergy and immunology Vol. 169; no. 2; pp. 125 - 129
• Main Authors: Rietveld, Mark J.A., Schreurs, Marco W.J., Gerth van Wijk, Roy, van Daele, Paul L.A., Hermans, Maud A.W.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.04.2016
• Subjects: Adult; Aged; Allergens - immunology; Anaphylaxis - complications; Anaphylaxis - diagnosis; Anaphylaxis - immunology; Animals; Antibody Specificity - immunology; Arthropod Venoms - immunology; Basophils - immunology; Basophils - metabolism; Female; Humans; Hymenoptera - immunology; Immunoglobulin E - blood; Immunoglobulin E - immunology; Insect Bites and Stings; Male; Mastocytosis, Systemic - complications; Middle Aged; Original Paper; Hymenoptera; Basophil activation; Systemic mastocytosis

Background: Systemic mastocytosis (SM) patients are at a high risk for anaphylaxis, with Hymenoptera as the main culprit. A screening instrument to identify which patients are sensitized to Hymenoptera before they experience anaphylaxis would therefore be of great value. The basophil activation test...