Regulation of TIA-1 Condensates: Zn2+ and RGG Motifs Promote Nucleic Acid Driven LLPS and Inhibit Irreversible Aggregation

• Published in: Frontiers in Molecular Biosciences Vol. 9; p. 960806
• Main Authors: West, DL, Loughlin, FE, Rivero-Rodriguez, F, Vankadari, N, Velazquez-Cruz, A, Corrales-Guerrero, L, Diaz-Moreno, I, Wilce, JA
• Format: Journal Article
• Language: English
• Published: Frontiers Media SA 14.07.2022; Frontiers Media S.A
• Subjects: amyloid fibril; Biology (General); liquid-liquid phase separation; Molecular Biosciences; Prion-like domain; QH301-705.5; RGG motif; RNA binding protein; RRM; TIA1; Zinc

Stress granules are non-membrane bound RNA-protein granules essential for survival during acute cellular stress. TIA-1 is a key protein in the formation of stress granules that undergoes liquid-liquid phase separation by association with specific RNAs and protein-protein interactions. However, the f...