Impact of Epithelial Claudin-4 and Leukotriene B4 Receptor 2 in Normoganglionic Hirschsprung Disease Colon on Post Pull-through Enterocolitis

• Published in: Journal of pediatric surgery Vol. 60; no. 1; p. 161900
• Main Authors: Abe, Kumpei, Takeda, Masahiro, Ishiyama, Asuka, Shimizu, Masahiro, Goto, Hiroki, Iida, Hisae, Fujimoto, Takashi, Ueda-Abe, Eri, Yamada, Shunsuke, Fujiwara, Kentaro, Shibuya, Soichi, Ochi, Takanori, Arii, Rumi, Yazaki, Yuta, Miyano, Go, Urao, Masahiko, Okazaki, Tadaharu, Koga, Hiroyuki, Lane, Geoffrey J., Yamataka, Atsuyuki, Suda, Kazuto
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2025
• Subjects: Claudin-4; Claudin-4 - genetics; Claudin-4 - metabolism; Colon - metabolism; Colon - surgery; Enterocolitis - etiology; Enterocolitis - metabolism; Female; Hirschsprung disease; Hirschsprung Disease - metabolism; Hirschsprung Disease - surgery; Humans; Infant; Leukotriene B4 receptor 2; Male; Post pull-through Hirschsprung-associated enterocolitis; Postoperative Complications - etiology; Postoperative Complications - metabolism; Receptors, Leukotriene; Tight junction protein; Post pull-through Hirschsprung-associated enterocolitis; post-PT HAEC; PT; D/T; Leukotriene B4 receptor 2; BLT-2; Tight junction protein; Claudin-4; HD-A; Hirschsprung disease; JAM; R/RS; qPCR; TJP; HD; HD-N

To investigate whether Leukotriene B4 receptor 2 (BLT-2), an upstream regulator of tight junction protein (TJP) Claudin-4, and TJPs could be etiologic factors in Hirschsprung-associated enterocolitis (HAEC) after pull-through (PT) for Hirschsprung disease (HD). Normoganglionic colon (HD-N) and agang...