Gender differences in response to differing antidepressant drug classes: two negative studies

• Published in: Psychological medicine Vol. 33; no. 8; pp. 1473 - 1477
• Main Authors: PARKER, G., PARKER, K., AUSTIN, M.-P., MITCHELL, P., BROTCHIE, H.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.11.2003
• Subjects: Adult; Age Factors; Antidepressant drugs; Antidepressive Agents, Second-Generation - therapeutic use; Antidepressive Agents, Tricyclic - therapeutic use; Australia; Biological and medical sciences; Brief Communication; Depression; Depressive Disorder - diagnosis; Depressive Disorder - drug therapy; Depressive Disorder - psychology; Female; Gender differences; Humans; Male; Medical sciences; Middle Aged; Neuropharmacology; Patients; Pharmacology. Drug treatments; Prospective Studies; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Reproducibility of Results; Retrospective Studies; Serotonin Uptake Inhibitors - therapeutic use; Sex Factors; Treatment; Treatment Outcome; United States; Australia; United States; Mood disorder; Human; Serotonin; Psychotropic; Treatment efficiency; Sex; Antidepressant agent; Depression; Reuptake inhibitor

Background. A recent US study presented data suggesting that depressed women are more likely to respond to selective serotonin reuptake inhibitor (SSRI) than tricyclic (TCA) antidepressant drug therapies. We have undertaken replication studies in two independent databases. Method. We have examined f...