Embelin (2,5-dihydroxy-3-undecyl-p-benzoquinone): A bioactive molecule isolated from Embelia ribes as an effective photodynamic therapeutic candidate against tumor in vivo

• Published in: Phytomedicine (Stuttgart) Vol. 21; no. 11; pp. 1292 - 1297
• Main Authors: Joy, Beena, Nishanth Kumar, S., Soumya, M.S., Radhika, A.R., Vibin, M., Abraham, Annie
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 25.09.2014; Urban & Fischer Verlag
• Subjects: Animals; Benzoquinones - pharmacology; Carcinoma, Ehrlich Tumor - drug therapy; Care and treatment; Cell Line, Tumor; Embelia - chemistry; Embelin; Male; Medicine, Botanic; Medicine, Herbal; Mice; Pharmacognosy; Pharmacology, Experimental; Photochemotherapy; Photodynamic therapy; Solid tumor; Swiss albino mice; Tumors; Swiss albino mice; Solid tumor; Photodynamic therapy; Embelin

The present study was carried out to assess the photosensitizing potential of embelin, the biologically active natural product isolated from Embelia ribes in photodynamic therapy (PDT) experiments in vivo. In vitro PDT clearly indicated that embelin recorded significant cytotoxicity in Ehrlich'...